Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.
Identifieur interne : 003E23 ( Main/Exploration ); précédent : 003E22; suivant : 003E24Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.
Auteurs : B. Stage-Marroquín [États-Unis] ; N. Pech ; E. GoldwasserSource :
- Experimental hematology [ 0301-472X ] ; 1996.
Descripteurs français
- KwdFr :
- Animaux, Cellules cancéreuses en culture, Division cellulaire (), Leucémie érythroblastique aigüe (anatomopathologie), Leucémie érythroblastique aigüe (métabolisme), Oligonucléotides antisens (pharmacologie), Récepteur érythropoïétine (antagonistes et inhibiteurs), Récepteur érythropoïétine (métabolisme), Souris, Thionucléotides (pharmacologie), Virus de la leucémie murine de Friend, Érythropoïétine (antagonistes et inhibiteurs), Érythropoïétine (métabolisme).
- MESH :
- anatomopathologie : Leucémie érythroblastique aigüe.
- antagonistes et inhibiteurs : Récepteur érythropoïétine, Érythropoïétine.
- métabolisme : Leucémie érythroblastique aigüe, Récepteur érythropoïétine, Érythropoïétine.
- pharmacologie : Oligonucléotides antisens, Thionucléotides.
- Animaux, Cellules cancéreuses en culture, Division cellulaire, Souris, Virus de la leucémie murine de Friend.
English descriptors
- KwdEn :
- Animals, Cell Division (drug effects), Erythropoietin (antagonists & inhibitors), Erythropoietin (metabolism), Friend murine leukemia virus, Leukemia, Erythroblastic, Acute (metabolism), Leukemia, Erythroblastic, Acute (pathology), Mice, Oligonucleotides, Antisense (pharmacology), Receptors, Erythropoietin (antagonists & inhibitors), Receptors, Erythropoietin (metabolism), Thionucleotides (pharmacology), Tumor Cells, Cultured.
- MESH :
- chemical , antagonists & inhibitors : Erythropoietin, Receptors, Erythropoietin.
- drug effects : Cell Division.
- chemical , metabolism : Erythropoietin, Leukemia, Erythroblastic, Acute, Receptors, Erythropoietin.
- pathology : Leukemia, Erythroblastic, Acute.
- chemical , pharmacology : Oligonucleotides, Antisense, Thionucleotides.
- Animals, Friend murine leukemia virus, Mice, Tumor Cells, Cultured.
Abstract
Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.
PubMed: 8862443
Affiliations:
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Le document en format XML
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<term>Erythropoietin (metabolism)</term>
<term>Friend murine leukemia virus</term>
<term>Leukemia, Erythroblastic, Acute (metabolism)</term>
<term>Leukemia, Erythroblastic, Acute (pathology)</term>
<term>Mice</term>
<term>Oligonucleotides, Antisense (pharmacology)</term>
<term>Receptors, Erythropoietin (antagonists & inhibitors)</term>
<term>Receptors, Erythropoietin (metabolism)</term>
<term>Thionucleotides (pharmacology)</term>
<term>Tumor Cells, Cultured</term>
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<term>Cellules cancéreuses en culture</term>
<term>Division cellulaire ()</term>
<term>Leucémie érythroblastique aigüe (anatomopathologie)</term>
<term>Leucémie érythroblastique aigüe (métabolisme)</term>
<term>Oligonucléotides antisens (pharmacologie)</term>
<term>Récepteur érythropoïétine (antagonistes et inhibiteurs)</term>
<term>Récepteur érythropoïétine (métabolisme)</term>
<term>Souris</term>
<term>Thionucléotides (pharmacologie)</term>
<term>Virus de la leucémie murine de Friend</term>
<term>Érythropoïétine (antagonistes et inhibiteurs)</term>
<term>Érythropoïétine (métabolisme)</term>
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<term>Receptors, Erythropoietin</term>
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<term>Receptors, Erythropoietin</term>
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<term>Récepteur érythropoïétine</term>
<term>Érythropoïétine</term>
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<term>Cellules cancéreuses en culture</term>
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<front><div type="abstract" xml:lang="en">Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.</div>
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<country name="États-Unis"><region name="Illinois"><name sortKey="Stage Marroquin, B" sort="Stage Marroquin, B" uniqKey="Stage Marroquin B" first="B" last="Stage-Marroquín">B. Stage-Marroquín</name>
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