Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.
Identifieur interne : 002A36 ( Ncbi/Merge ); précédent : 002A35; suivant : 002A37Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.
Auteurs : B. Stage-Marroquín [États-Unis] ; N. Pech ; E. GoldwasserSource :
- Experimental hematology [ 0301-472X ] ; 1996.
Descripteurs français
- KwdFr :
- Animaux, Cellules cancéreuses en culture, Division cellulaire (), Leucémie érythroblastique aigüe (anatomopathologie), Leucémie érythroblastique aigüe (métabolisme), Oligonucléotides antisens (pharmacologie), Récepteur érythropoïétine (antagonistes et inhibiteurs), Récepteur érythropoïétine (métabolisme), Souris, Thionucléotides (pharmacologie), Virus de la leucémie murine de Friend, Érythropoïétine (antagonistes et inhibiteurs), Érythropoïétine (métabolisme).
- MESH :
- anatomopathologie : Leucémie érythroblastique aigüe.
- antagonistes et inhibiteurs : Récepteur érythropoïétine, Érythropoïétine.
- métabolisme : Leucémie érythroblastique aigüe, Récepteur érythropoïétine, Érythropoïétine.
- pharmacologie : Oligonucléotides antisens, Thionucléotides.
- Animaux, Cellules cancéreuses en culture, Division cellulaire, Souris, Virus de la leucémie murine de Friend.
English descriptors
- KwdEn :
- Animals, Cell Division (drug effects), Erythropoietin (antagonists & inhibitors), Erythropoietin (metabolism), Friend murine leukemia virus, Leukemia, Erythroblastic, Acute (metabolism), Leukemia, Erythroblastic, Acute (pathology), Mice, Oligonucleotides, Antisense (pharmacology), Receptors, Erythropoietin (antagonists & inhibitors), Receptors, Erythropoietin (metabolism), Thionucleotides (pharmacology), Tumor Cells, Cultured.
- MESH :
- chemical , antagonists & inhibitors : Erythropoietin, Receptors, Erythropoietin.
- drug effects : Cell Division.
- chemical , metabolism : Erythropoietin, Leukemia, Erythroblastic, Acute, Receptors, Erythropoietin.
- pathology : Leukemia, Erythroblastic, Acute.
- chemical , pharmacology : Oligonucleotides, Antisense, Thionucleotides.
- Animals, Friend murine leukemia virus, Mice, Tumor Cells, Cultured.
Abstract
Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.
PubMed: 8862443
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pubmed:8862443Le document en format XML
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In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8862443</PMID><DateCompleted><Year>1996</Year><Month>11</Month><Day>19</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0301-472X</ISSN><JournalIssue CitedMedium="Print"><Volume>24</Volume><Issue>11</Issue><PubDate><Year>1996</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Experimental hematology</Title><ISOAbbreviation>Exp. Hematol.</ISOAbbreviation></Journal><ArticleTitle>Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.</ArticleTitle><Pagination><MedlinePgn>1322-6</MedlinePgn></Pagination><Abstract><AbstractText>Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stage-Marroquín</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pech</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Goldwasser</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HD07136</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL21676</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL30121</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Exp Hematol</MedlineTA><NlmUniqueID>0402313</NlmUniqueID><ISSNLinking>0301-472X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016376">Oligonucleotides, Antisense</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017467">Receptors, Erythropoietin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013873">Thionucleotides</NameOfSubstance></Chemical><Chemical><RegistryNumber>11096-26-7</RegistryNumber><NameOfSubstance UI="D004921">Erythropoietin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002455" MajorTopicYN="N">Cell Division</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004921" MajorTopicYN="N">Erythropoietin</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005622" MajorTopicYN="Y">Friend murine leukemia virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004915" MajorTopicYN="N">Leukemia, Erythroblastic, Acute</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016376" MajorTopicYN="N">Oligonucleotides, Antisense</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017467" MajorTopicYN="N">Receptors, Erythropoietin</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013873" MajorTopicYN="N">Thionucleotides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014407" MajorTopicYN="N">Tumor Cells, Cultured</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8862443</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de Chicago</li></orgName></list><tree><noCountry><name sortKey="Goldwasser, E" sort="Goldwasser, E" uniqKey="Goldwasser E" first="E" last="Goldwasser">E. Goldwasser</name><name sortKey="Pech, N" sort="Pech, N" uniqKey="Pech N" first="N" last="Pech">N. Pech</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Stage Marroquin, B" sort="Stage Marroquin, B" uniqKey="Stage Marroquin B" first="B" last="Stage-Marroquín">B. Stage-Marroquín</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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