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Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.

Identifieur interne : 003E23 ( Main/Curation ); précédent : 003E22; suivant : 003E24

Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.

Auteurs : B. Stage-Marroquín [États-Unis] ; N. Pech ; E. Goldwasser

Source :

RBID : pubmed:8862443

Descripteurs français

English descriptors

Abstract

Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.

PubMed: 8862443

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pubmed:8862443

Le document en format XML

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<title xml:lang="en">Internal autocrine regulation by erythropoietin of erythroleukemic cell proliferation.</title>
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<name sortKey="Stage Marroquin, B" sort="Stage Marroquin, B" uniqKey="Stage Marroquin B" first="B" last="Stage-Marroquín">B. Stage-Marroquín</name>
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<nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637</wicri:regionArea>
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<region type="state">Illinois</region>
<settlement type="city">Chicago</settlement>
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<orgName type="university">Université de Chicago</orgName>
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<name sortKey="Pech, N" sort="Pech, N" uniqKey="Pech N" first="N" last="Pech">N. Pech</name>
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<name sortKey="Goldwasser, E" sort="Goldwasser, E" uniqKey="Goldwasser E" first="E" last="Goldwasser">E. Goldwasser</name>
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<term>Erythropoietin (metabolism)</term>
<term>Friend murine leukemia virus</term>
<term>Leukemia, Erythroblastic, Acute (metabolism)</term>
<term>Leukemia, Erythroblastic, Acute (pathology)</term>
<term>Mice</term>
<term>Oligonucleotides, Antisense (pharmacology)</term>
<term>Receptors, Erythropoietin (antagonists & inhibitors)</term>
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<term>Cellules cancéreuses en culture</term>
<term>Division cellulaire ()</term>
<term>Leucémie érythroblastique aigüe (anatomopathologie)</term>
<term>Leucémie érythroblastique aigüe (métabolisme)</term>
<term>Oligonucléotides antisens (pharmacologie)</term>
<term>Récepteur érythropoïétine (antagonistes et inhibiteurs)</term>
<term>Récepteur érythropoïétine (métabolisme)</term>
<term>Souris</term>
<term>Thionucléotides (pharmacologie)</term>
<term>Virus de la leucémie murine de Friend</term>
<term>Érythropoïétine (antagonistes et inhibiteurs)</term>
<term>Érythropoïétine (métabolisme)</term>
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<term>Érythropoïétine</term>
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<term>Receptors, Erythropoietin</term>
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<term>Leucémie érythroblastique aigüe</term>
<term>Récepteur érythropoïétine</term>
<term>Érythropoïétine</term>
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<term>Leukemia, Erythroblastic, Acute</term>
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<term>Oligonucléotides antisens</term>
<term>Thionucléotides</term>
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<term>Oligonucleotides, Antisense</term>
<term>Thionucleotides</term>
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<term>Friend murine leukemia virus</term>
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<div type="abstract" xml:lang="en">Antisense oligomers (18 mers) corresponding to the erythropoietin and erythropoietin receptor 5' coding sequences cause marked suppression of proliferation of several lines of erythroleukemic cells. In these systems, phosphorothioate protected sense oligomers are inhibitory, while the unmodified sense oligomers have no significant effect on cell growth. These data indicate that proliferation of some erythroleukemic cells is under internal autocrine regulation by erythropoietin and its receptor.</div>
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