The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines
Identifieur interne : 003638 ( Main/Exploration ); précédent : 003637; suivant : 003639The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines
Auteurs : T. A. Jones [Royaume-Uni] ; R. H. Flomen [Royaume-Uni] ; G. Senger [Allemagne] ; D. Nižeti [Royaume-Uni] ; D. Sheer [Royaume-Uni]Source :
- European Journal of Cancer [ 0959-8049 ] ; 2000.
English descriptors
- Teeft :
- Cell line, Cell lines, Chromosome, Chromosome band, Clone, Contig, Ddx1, Erythroleukaemia cell line, European journal, Gene, Genomic, Genomic clone, Hgmp resource centre, High expression, High levels, Homeobox, Homeobox gene, Homeobox genes, Hybridisation, Leukaemia, Life technologies, Medulloblastoma, Medulloblastoma cell lines, Meis1, Meis1 expression, Meis1 gene, Mrna, Mycn, Myeloid, Myeloid ecotropic integration site, Neuroblastoma, Neuroblastoma cell line, Neuroblastoma cell lines, Other neuroblastoma, Pac, Positive clones, Tumour.
Abstract
Abstract: Neuroblastoma is a childhood tumour of the sympathetic nervous system that demonstrates striking clinical heterogeneity. In order to determine which genes are abnormally expressed in neuroblastoma, we screened regions of amplification from the short arm of chromosome 2 in the neuroblastoma cell line IMR-32 and found that the homeobox gene, myeloid ecotropic integration site 1 (MEIS1), is highly amplified. MEIS1 normally maps to chromosome band 2p14. High expression of MEIS1 without amplification was also found in other neuroblastoma cell lines, with and without MYCN amplification, and in medulloblastoma and erythroleukaemia cell lines. MEIS1 is highly expressed in cerebellum and ubiquitously expressed in normal immunohaematopoietic tissues and is thought to be important in cell proliferation and differentiation. While several lines of evidence point towards a role for homeobox genes in the development of other malignancies, this is the first report showing the amplification of a homeobox gene in neuroblastoma.
Url:
DOI: 10.1016/S0959-8049(00)00332-4
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001581
- to stream Istex, to step Curation: 001581
- to stream Istex, to step Checkpoint: 000F37
- to stream Main, to step Merge: 003680
- to stream Main, to step Curation: 003638
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines</title><author><name sortKey="Jones, T A" sort="Jones, T A" uniqKey="Jones T" first="T. A." last="Jones">T. A. Jones</name></author><author><name sortKey="Flomen, R H" sort="Flomen, R H" uniqKey="Flomen R" first="R. H." last="Flomen">R. H. Flomen</name></author><author><name sortKey="Senger, G" sort="Senger, G" uniqKey="Senger G" first="G." last="Senger">G. Senger</name></author><author><name sortKey="Nizeti, D" sort="Nizeti, D" uniqKey="Nizeti D" first="D." last="Nižeti">D. Nižeti</name></author><author><name sortKey="Sheer, D" sort="Sheer, D" uniqKey="Sheer D" first="D." last="Sheer">D. Sheer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8B61ADE4248EFF33C6B120F0050947F7480F89D6</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0959-8049(00)00332-4</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-DHFX91T3-2/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001581</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001581</idno><idno type="wicri:Area/Istex/Curation">001581</idno><idno type="wicri:Area/Istex/Checkpoint">000F37</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F37</idno><idno type="wicri:doubleKey">0959-8049:2000:Jones T:the:homeobox:gene</idno><idno type="wicri:Area/Main/Merge">003680</idno><idno type="wicri:Area/Main/Curation">003638</idno><idno type="wicri:Area/Main/Exploration">003638</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines</title><author><name sortKey="Jones, T A" sort="Jones, T A" uniqKey="Jones T" first="T. A." last="Jones">T. A. Jones</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Cytogenetics Laboratory, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX</wicri:regionArea><wicri:noRegion>London WC2A 3PX</wicri:noRegion></affiliation></author><author><name sortKey="Flomen, R H" sort="Flomen, R H" uniqKey="Flomen R" first="R. H." last="Flomen">R. H. Flomen</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Applied Molecular Biology, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Senger, G" sort="Senger, G" uniqKey="Senger G" first="G." last="Senger">G. Senger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Practice of Medical Genetics and Gynaecology, Roritzerstr. 2, 93049 Regensburg</wicri:regionArea><wicri:noRegion>93049 Regensburg</wicri:noRegion><wicri:noRegion>93049 Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Nizeti, D" sort="Nizeti, D" uniqKey="Nizeti D" first="D." last="Nižeti">D. Nižeti</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Applied Molecular Biology, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sheer, D" sort="Sheer, D" uniqKey="Sheer D" first="D." last="Sheer">D. Sheer</name><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Cytogenetics Laboratory, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX</wicri:regionArea><wicri:noRegion>London WC2A 3PX</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Cancer</title><title level="j" type="abbrev">EJC</title><idno type="ISSN">0959-8049</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">18</biblScope><biblScope unit="page" from="2368">2368</biblScope><biblScope unit="page" to="2374">2374</biblScope></imprint><idno type="ISSN">0959-8049</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-8049</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Cell line</term><term>Cell lines</term><term>Chromosome</term><term>Chromosome band</term><term>Clone</term><term>Contig</term><term>Ddx1</term><term>Erythroleukaemia cell line</term><term>European journal</term><term>Gene</term><term>Genomic</term><term>Genomic clone</term><term>Hgmp resource centre</term><term>High expression</term><term>High levels</term><term>Homeobox</term><term>Homeobox gene</term><term>Homeobox genes</term><term>Hybridisation</term><term>Leukaemia</term><term>Life technologies</term><term>Medulloblastoma</term><term>Medulloblastoma cell lines</term><term>Meis1</term><term>Meis1 expression</term><term>Meis1 gene</term><term>Mrna</term><term>Mycn</term><term>Myeloid</term><term>Myeloid ecotropic integration site</term><term>Neuroblastoma</term><term>Neuroblastoma cell line</term><term>Neuroblastoma cell lines</term><term>Other neuroblastoma</term><term>Pac</term><term>Positive clones</term><term>Tumour</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Neuroblastoma is a childhood tumour of the sympathetic nervous system that demonstrates striking clinical heterogeneity. In order to determine which genes are abnormally expressed in neuroblastoma, we screened regions of amplification from the short arm of chromosome 2 in the neuroblastoma cell line IMR-32 and found that the homeobox gene, myeloid ecotropic integration site 1 (MEIS1), is highly amplified. MEIS1 normally maps to chromosome band 2p14. High expression of MEIS1 without amplification was also found in other neuroblastoma cell lines, with and without MYCN amplification, and in medulloblastoma and erythroleukaemia cell lines. MEIS1 is highly expressed in cerebellum and ubiquitously expressed in normal immunohaematopoietic tissues and is thought to be important in cell proliferation and differentiation. While several lines of evidence point towards a role for homeobox genes in the development of other malignancies, this is the first report showing the amplification of a homeobox gene in neuroblastoma.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Jones, T A" sort="Jones, T A" uniqKey="Jones T" first="T. A." last="Jones">T. A. Jones</name></noRegion><name sortKey="Flomen, R H" sort="Flomen, R H" uniqKey="Flomen R" first="R. H." last="Flomen">R. H. Flomen</name><name sortKey="Nizeti, D" sort="Nizeti, D" uniqKey="Nizeti D" first="D." last="Nižeti">D. Nižeti</name><name sortKey="Sheer, D" sort="Sheer, D" uniqKey="Sheer D" first="D." last="Sheer">D. Sheer</name><name sortKey="Sheer, D" sort="Sheer, D" uniqKey="Sheer D" first="D." last="Sheer">D. Sheer</name></country><country name="Allemagne"><noRegion><name sortKey="Senger, G" sort="Senger, G" uniqKey="Senger G" first="G." last="Senger">G. Senger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003638 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003638 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:8B61ADE4248EFF33C6B120F0050947F7480F89D6
|texte= The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines
}}
| This area was generated with Dilib version V0.6.33. |  |