Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?
Identifieur interne : 001536 ( Main/Exploration ); précédent : 001535; suivant : 001537Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?
Auteurs : Ali S. Omrani ; Ziad A. MemishSource :
- Current Treatment Options in Infectious Diseases [ 1523-3820 ] ; 2015.
Abstract
Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. However, their safety and efficacy require confirmation in animal models and exploratory clinical trials.
Url:
DOI: 10.1007/s40506-015-0048-2
PubMed: 32226324
PubMed Central: 7100761
Affiliations:
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Omrani</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University & Ministry of Health,</institution></institution-wrap>P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11514 Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Current Treatment Options in Infectious Diseases</title><idno type="ISSN">1523-3820</idno><idno type="eISSN">1534-6250</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. 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uniqKey="Shalhoub S">S Shalhoub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shalhoub, S" uniqKey="Shalhoub S">S Shalhoub</name></author><author><name sortKey="Alzahrani, A" uniqKey="Alzahrani A">A AlZahrani</name></author><author><name sortKey="Simhairi, R" uniqKey="Simhairi R">R Simhairi</name></author><author><name sortKey="Mushtaq, A" uniqKey="Mushtaq A">A Mushtaq</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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