A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
Identifieur interne : 000F20 ( Main/Exploration ); précédent : 000F19; suivant : 000F21A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
Auteurs : Siming Tang [République populaire de Chine] ; Wanbiao Ma [République populaire de Chine] ; Peifan Bai [République populaire de Chine]Source :
- Computational and Mathematical Methods in Medicine [ 1748-670X ] ; 2017.
Descripteurs français
- KwdFr :
- Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme), Dipeptidyl peptidase 4 (génétique), Humains, Infections à coronavirus (enzymologie), Infections à coronavirus (épidémiologie), Interactions hôte-pathogène, Modèles biologiques, Muqueuse respiratoire (enzymologie), Muqueuse respiratoire (virologie), Récepteurs viraux (métabolisme), Régulation de l'expression des gènes codant pour des enzymes.
- MESH :
- enzymologie : Infections à coronavirus, Muqueuse respiratoire.
- génétique : Dipeptidyl peptidase 4.
- métabolisme : Coronavirus du syndrome respiratoire du Moyen-Orient, Récepteurs viraux.
- virologie : Muqueuse respiratoire.
- épidémiologie : Infections à coronavirus.
- Humains, Interactions hôte-pathogène, Modèles biologiques, Régulation de l'expression des gènes codant pour des enzymes.
English descriptors
- KwdEn :
- Coronavirus Infections (enzymology), Coronavirus Infections (epidemiology), Dipeptidyl Peptidase 4 (genetics), Gene Expression Regulation, Enzymologic, Host-Pathogen Interactions, Humans, Middle East Respiratory Syndrome Coronavirus (metabolism), Models, Biological, Receptors, Virus (metabolism), Respiratory Mucosa (enzymology), Respiratory Mucosa (virology).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- enzymology : Coronavirus Infections, Respiratory Mucosa.
- epidemiology : Coronavirus Infections.
- metabolism : Middle East Respiratory Syndrome Coronavirus, Receptors, Virus.
- virology : Respiratory Mucosa.
- Gene Expression Regulation, Enzymologic, Host-Pathogen Interactions, Humans, Models, Biological.
Abstract
The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.
Url:
DOI: 10.1155/2017/5285810
PubMed: 28894474
PubMed Central: 5574235
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.</p>
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