A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
Identifieur interne : 001B73 ( Ncbi/Curation ); précédent : 001B72; suivant : 001B74A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
Auteurs : Siming Tang [République populaire de Chine] ; Wanbiao Ma [République populaire de Chine] ; Peifan Bai [République populaire de Chine]Source :
- Computational and Mathematical Methods in Medicine [ 1748-670X ] ; 2017.
Descripteurs français
- KwdFr :
- Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme), Dipeptidyl peptidase 4 (génétique), Humains, Infections à coronavirus (enzymologie), Infections à coronavirus (épidémiologie), Interactions hôte-pathogène, Modèles biologiques, Muqueuse respiratoire (enzymologie), Muqueuse respiratoire (virologie), Récepteurs viraux (métabolisme), Régulation de l'expression des gènes codant pour des enzymes.
- MESH :
- enzymologie : Infections à coronavirus, Muqueuse respiratoire.
- génétique : Dipeptidyl peptidase 4.
- métabolisme : Coronavirus du syndrome respiratoire du Moyen-Orient, Récepteurs viraux.
- virologie : Muqueuse respiratoire.
- épidémiologie : Infections à coronavirus.
- Humains, Interactions hôte-pathogène, Modèles biologiques, Régulation de l'expression des gènes codant pour des enzymes.
English descriptors
- KwdEn :
- Coronavirus Infections (enzymology), Coronavirus Infections (epidemiology), Dipeptidyl Peptidase 4 (genetics), Gene Expression Regulation, Enzymologic, Host-Pathogen Interactions, Humans, Middle East Respiratory Syndrome Coronavirus (metabolism), Models, Biological, Receptors, Virus (metabolism), Respiratory Mucosa (enzymology), Respiratory Mucosa (virology).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- enzymology : Coronavirus Infections, Respiratory Mucosa.
- epidemiology : Coronavirus Infections.
- metabolism : Middle East Respiratory Syndrome Coronavirus, Receptors, Virus.
- virology : Respiratory Mucosa.
- Gene Expression Regulation, Enzymologic, Host-Pathogen Interactions, Humans, Models, Biological.
Abstract
The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.
Url:
DOI: 10.1155/2017/5285810
PubMed: 28894474
PubMed Central: 5574235
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Bai</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Computational and Mathematical Methods in Medicine</title><idno type="ISSN">1748-670X</idno><idno type="eISSN">1748-6718</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus Infections (enzymology)</term><term>Coronavirus Infections (epidemiology)</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Gene Expression Regulation, Enzymologic</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (metabolism)</term><term>Models, Biological</term><term>Receptors, Virus (metabolism)</term><term>Respiratory Mucosa (enzymology)</term><term>Respiratory Mucosa (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Humains</term><term>Infections à coronavirus (enzymologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Interactions hôte-pathogène</term><term>Modèles biologiques</term><term>Muqueuse respiratoire (enzymologie)</term><term>Muqueuse respiratoire (virologie)</term><term>Récepteurs viraux (métabolisme)</term><term>Régulation de l'expression des gènes codant pour des enzymes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" 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scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation, Enzymologic</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Models, Biological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Interactions hôte-pathogène</term><term>Modèles biologiques</term><term>Régulation de l'expression des gènes codant pour des enzymes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. 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Wohlford-Lenane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. De Wit</name></author><author><name sortKey="Rasmussen, A L" uniqKey="Rasmussen A">A. L. Rasmussen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogers, K" uniqKey="Rogers K">K. Rogers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, R M" uniqKey="Anderson R">R. M. Anderson</name></author><author><name sortKey="May, R M" uniqKey="May R">R. M. May</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nowak, M A" uniqKey="Nowak M">M. A. Nowak</name></author><author><name sortKey="Bangham, C R M" uniqKey="Bangham C">C. R. M. Bangham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nowak, M A" uniqKey="Nowak M">M. A. Nowak</name></author><author><name sortKey="May, R M" uniqKey="May R">R. M. May</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perelson, A S" uniqKey="Perelson A">A. S. Perelson</name></author><author><name sortKey="Nelson, P W" uniqKey="Nelson P">P. W. Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mille, J K" uniqKey="Mille J">J. K. Mille</name></author><author><name sortKey="Whittaker, G R" uniqKey="Whittaker G">G. R. Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korobeinikov, A" uniqKey="Korobeinikov A">A. Korobeinikov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korobeinikov, A" uniqKey="Korobeinikov A">A. Korobeinikov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccluskey, C C" uniqKey="Mccluskey C">C. C. McCluskey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, G" uniqKey="Huang G">G. Huang</name></author><author><name sortKey="Ma, W" uniqKey="Ma W">W. Ma</name></author><author><name sortKey="Takeuchi, Y" uniqKey="Takeuchi Y">Y. Takeuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Ma, W" uniqKey="Ma W">W. Ma</name></author><author><name sortKey="Jiang, Z" uniqKey="Jiang Z">Z. Jiang</name></author><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolkowicz, G S" uniqKey="Wolkowicz G">G. S. Wolkowicz</name></author><author><name sortKey="Lu, Z Q" uniqKey="Lu Z">Z. Q. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, Y" uniqKey="Saito Y">Y. Saito</name></author><author><name sortKey="Hara, T" uniqKey="Hara T">T. Hara</name></author><author><name sortKey="Ma, W" uniqKey="Ma W">W. Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, Y X" uniqKey="Qin Y">Y. X. Qin</name></author><author><name sortKey="Wang, M Q" uniqKey="Wang M">M. Q. Wang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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