Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.
Identifieur interne : 000E86 ( Main/Exploration ); précédent : 000E85; suivant : 000E87Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.
Auteurs : Abdulkarim Alhetheel [Arabie saoudite] ; Haifa Altalhi [Arabie saoudite] ; Ahmed Albarrag [Arabie saoudite] ; Zahid Shakoor [Arabie saoudite] ; Deqa Mohamed [Arabie saoudite] ; Malak El-Hazmi [Arabie saoudite] ; Ali Somily [Arabie saoudite] ; Mazin Barry [Arabie saoudite] ; Muhammed Bakhrebah [Arabie saoudite] ; Majed Nassar [Arabie saoudite]Source :
- Viral immunology [ 1557-8976 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN viral (sang), Anticorps antiviraux (sang), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Grippe humaine (diagnostic), Grippe humaine (immunologie), Humains, Immunoglobuline G (sang), Infections à coronavirus (diagnostic), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Pronostic, Sous-type H1N1 du virus de la grippe A (immunologie), Virus influenza B (immunologie).
- MESH :
- diagnostic : Grippe humaine, Infections à coronavirus.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Grippe humaine, Infections à coronavirus, Sous-type H1N1 du virus de la grippe A, Virus influenza B.
- sang : ARN viral, Anticorps antiviraux, Immunoglobuline G.
- virologie : Infections à coronavirus.
- Humains, Pronostic.
English descriptors
- KwdEn :
- Antibodies, Viral (blood), Coronavirus Infections (diagnosis), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Immunoglobulin G (blood), Influenza A Virus, H1N1 Subtype (immunology), Influenza B virus (immunology), Influenza, Human (diagnosis), Influenza, Human (immunology), Middle East Respiratory Syndrome Coronavirus (immunology), Prognosis, RNA, Viral (blood).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, RNA, Viral.
- diagnosis : Coronavirus Infections, Influenza, Human.
- immunology : Coronavirus Infections, Influenza A Virus, H1N1 Subtype, Influenza B virus, Influenza, Human, Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Humans, Prognosis.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before. All underwent MERS-CoV RNA and MERS-CoV-IgG testing. Thirty patients were found to be MERS-CoV RNA positive; however, during serological analysis, only 6 (3.4%) patients were positive for MERS-CoV-IgG, 1 (0.6%) patient was equivocal, and 167 (96%) patients were negative. Among the serological positives, four were recently MERS-CoV RNA positive and two were MERS-CoV RNA negative. No cross-reactivity to influenza A or B was detected. Based on the lack of correlation between nucleic acid and serological analysis, we conclude that MERS-CoV-IgG testing may not be suitable for diagnosing acute infection or estimating its prevalence during an outbreak. In addition, our findings show that MERS-CoV-IgG may not have significant value in determining disease severity or prognosis.
DOI: 10.1089/vim.2017.0091
PubMed: 28873020
Affiliations:
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Coronavirus Infection.</title><author><name sortKey="Alhetheel, Abdulkarim" sort="Alhetheel, Abdulkarim" uniqKey="Alhetheel A" first="Abdulkarim" last="Alhetheel">Abdulkarim Alhetheel</name><affiliation wicri:level="1"><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1 King Khalid University Hospital , Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Altalhi, Haifa" sort="Altalhi, Haifa" uniqKey="Altalhi H" first="Haifa" last="Altalhi">Haifa Altalhi</name><affiliation wicri:level="1"><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1 King Khalid University Hospital , Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Albarrag, Ahmed" sort="Albarrag, Ahmed" uniqKey="Albarrag A" first="Ahmed" last="Albarrag">Ahmed Albarrag</name><affiliation wicri:level="1"><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1 King Khalid University Hospital , Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shakoor, Zahid" sort="Shakoor, Zahid" uniqKey="Shakoor Z" first="Zahid" last="Shakoor">Zahid Shakoor</name><affiliation wicri:level="1"><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1 King Khalid University Hospital , Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Mohamed, Deqa" sort="Mohamed, Deqa" uniqKey="Mohamed D" first="Deqa" last="Mohamed">Deqa Mohamed</name><affiliation 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xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1 King Khalid University Hospital , Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Barry, Mazin" sort="Barry, Mazin" uniqKey="Barry M" first="Mazin" last="Barry">Mazin Barry</name><affiliation wicri:level="1"><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1 King Khalid University Hospital , Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Bakhrebah, Muhammed" sort="Bakhrebah, Muhammed" uniqKey="Bakhrebah M" first="Muhammed" last="Bakhrebah">Muhammed Bakhrebah</name><affiliation wicri:level="1"><nlm:affiliation>4 King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia .</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>4 King Abdulaziz City for Science and Technology, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Nassar, Majed" sort="Nassar, Majed" uniqKey="Nassar M" first="Majed" last="Nassar">Majed Nassar</name><affiliation wicri:level="1"><nlm:affiliation>4 King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia .</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>4 King Abdulaziz City for Science and Technology, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Viral immunology</title><idno type="eISSN">1557-8976</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (blood)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza B virus (immunology)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (immunology)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Prognosis</term><term>RNA, Viral (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (sang)</term><term>Anticorps antiviraux (sang)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Grippe humaine (diagnostic)</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Pronostic</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Virus influenza B (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Grippe humaine</term><term>Infections à coronavirus</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza B virus</term><term>Influenza, Human</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term><term>Anticorps antiviraux</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Prognosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Pronostic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before. All underwent MERS-CoV RNA and MERS-CoV-IgG testing. Thirty patients were found to be MERS-CoV RNA positive; however, during serological analysis, only 6 (3.4%) patients were positive for MERS-CoV-IgG, 1 (0.6%) patient was equivocal, and 167 (96%) patients were negative. Among the serological positives, four were recently MERS-CoV RNA positive and two were MERS-CoV RNA negative. No cross-reactivity to influenza A or B was detected. Based on the lack of correlation between nucleic acid and serological analysis, we conclude that MERS-CoV-IgG testing may not be suitable for diagnosing acute infection or estimating its prevalence during an outbreak. In addition, our findings show that MERS-CoV-IgG may not have significant value in determining disease severity or prognosis.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Alhetheel, Abdulkarim" sort="Alhetheel, Abdulkarim" uniqKey="Alhetheel A" first="Abdulkarim" last="Alhetheel">Abdulkarim Alhetheel</name></noRegion><name sortKey="Albarrag, Ahmed" sort="Albarrag, Ahmed" uniqKey="Albarrag A" first="Ahmed" last="Albarrag">Ahmed Albarrag</name><name sortKey="Altalhi, Haifa" sort="Altalhi, Haifa" uniqKey="Altalhi H" first="Haifa" last="Altalhi">Haifa Altalhi</name><name sortKey="Bakhrebah, Muhammed" sort="Bakhrebah, Muhammed" uniqKey="Bakhrebah M" first="Muhammed" last="Bakhrebah">Muhammed Bakhrebah</name><name sortKey="Barry, Mazin" sort="Barry, Mazin" uniqKey="Barry M" first="Mazin" last="Barry">Mazin Barry</name><name sortKey="El Hazmi, Malak" sort="El Hazmi, Malak" uniqKey="El Hazmi M" first="Malak" last="El-Hazmi">Malak El-Hazmi</name><name sortKey="Mohamed, Deqa" sort="Mohamed, Deqa" uniqKey="Mohamed D" first="Deqa" last="Mohamed">Deqa Mohamed</name><name sortKey="Nassar, Majed" sort="Nassar, Majed" uniqKey="Nassar M" first="Majed" last="Nassar">Majed Nassar</name><name sortKey="Shakoor, Zahid" sort="Shakoor, Zahid" uniqKey="Shakoor Z" first="Zahid" last="Shakoor">Zahid Shakoor</name><name sortKey="Somily, Ali" sort="Somily, Ali" uniqKey="Somily A" first="Ali" last="Somily">Ali Somily</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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