Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.
Identifieur interne : 001B63 ( Ncbi/Curation ); précédent : 001B62; suivant : 001B64Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.
Auteurs : Abdulkarim Alhetheel [Arabie saoudite] ; Haifa Altalhi [Arabie saoudite] ; Ahmed Albarrag [Arabie saoudite] ; Zahid Shakoor [Arabie saoudite] ; Deqa Mohamed [Arabie saoudite] ; Malak El-Hazmi [Arabie saoudite] ; Ali Somily [Arabie saoudite] ; Mazin Barry [Arabie saoudite] ; Muhammed Bakhrebah [Arabie saoudite] ; Majed Nassar [Arabie saoudite]Source :
- Viral immunology [ 1557-8976 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN viral (sang), Anticorps antiviraux (sang), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Grippe humaine (diagnostic), Grippe humaine (immunologie), Humains, Immunoglobuline G (sang), Infections à coronavirus (diagnostic), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Pronostic, Sous-type H1N1 du virus de la grippe A (immunologie), Virus influenza B (immunologie).
- MESH :
- diagnostic : Grippe humaine, Infections à coronavirus.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Grippe humaine, Infections à coronavirus, Sous-type H1N1 du virus de la grippe A, Virus influenza B.
- sang : ARN viral, Anticorps antiviraux, Immunoglobuline G.
- virologie : Infections à coronavirus.
- Humains, Pronostic.
English descriptors
- KwdEn :
- Antibodies, Viral (blood), Coronavirus Infections (diagnosis), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Immunoglobulin G (blood), Influenza A Virus, H1N1 Subtype (immunology), Influenza B virus (immunology), Influenza, Human (diagnosis), Influenza, Human (immunology), Middle East Respiratory Syndrome Coronavirus (immunology), Prognosis, RNA, Viral (blood).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, RNA, Viral.
- diagnosis : Coronavirus Infections, Influenza, Human.
- immunology : Coronavirus Infections, Influenza A Virus, H1N1 Subtype, Influenza B virus, Influenza, Human, Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Humans, Prognosis.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before. All underwent MERS-CoV RNA and MERS-CoV-IgG testing. Thirty patients were found to be MERS-CoV RNA positive; however, during serological analysis, only 6 (3.4%) patients were positive for MERS-CoV-IgG, 1 (0.6%) patient was equivocal, and 167 (96%) patients were negative. Among the serological positives, four were recently MERS-CoV RNA positive and two were MERS-CoV RNA negative. No cross-reactivity to influenza A or B was detected. Based on the lack of correlation between nucleic acid and serological analysis, we conclude that MERS-CoV-IgG testing may not be suitable for diagnosing acute infection or estimating its prevalence during an outbreak. In addition, our findings show that MERS-CoV-IgG may not have significant value in determining disease severity or prognosis.
DOI: 10.1089/vim.2017.0091
PubMed: 28873020
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before. All underwent MERS-CoV RNA and MERS-CoV-IgG testing. Thirty patients were found to be MERS-CoV RNA positive; however, during serological analysis, only 6 (3.4%) patients were positive for MERS-CoV-IgG, 1 (0.6%) patient was equivocal, and 167 (96%) patients were negative. Among the serological positives, four were recently MERS-CoV RNA positive and two were MERS-CoV RNA negative. No cross-reactivity to influenza A or B was detected. Based on the lack of correlation between nucleic acid and serological analysis, we conclude that MERS-CoV-IgG testing may not be suitable for diagnosing acute infection or estimating its prevalence during an outbreak. In addition, our findings show that MERS-CoV-IgG may not have significant value in determining disease severity or prognosis.</div>
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