Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.
Identifieur interne : 000B69 ( PubMed/Corpus ); précédent : 000B68; suivant : 000B70Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.
Auteurs : Abdulkarim Alhetheel ; Haifa Altalhi ; Ahmed Albarrag ; Zahid Shakoor ; Deqa Mohamed ; Malak El-Hazmi ; Ali Somily ; Mazin Barry ; Muhammed Bakhrebah ; Majed NassarSource :
- Viral immunology [ 1557-8976 ] ; 2017.
English descriptors
- KwdEn :
- Antibodies, Viral (blood), Coronavirus Infections (diagnosis), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Immunoglobulin G (blood), Influenza A Virus, H1N1 Subtype (immunology), Influenza B virus (immunology), Influenza, Human (diagnosis), Influenza, Human (immunology), Middle East Respiratory Syndrome Coronavirus (immunology), Prognosis, RNA, Viral (blood).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, RNA, Viral.
- diagnosis : Coronavirus Infections, Influenza, Human.
- immunology : Coronavirus Infections, Influenza A Virus, H1N1 Subtype, Influenza B virus, Influenza, Human, Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Humans, Prognosis.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before. All underwent MERS-CoV RNA and MERS-CoV-IgG testing. Thirty patients were found to be MERS-CoV RNA positive; however, during serological analysis, only 6 (3.4%) patients were positive for MERS-CoV-IgG, 1 (0.6%) patient was equivocal, and 167 (96%) patients were negative. Among the serological positives, four were recently MERS-CoV RNA positive and two were MERS-CoV RNA negative. No cross-reactivity to influenza A or B was detected. Based on the lack of correlation between nucleic acid and serological analysis, we conclude that MERS-CoV-IgG testing may not be suitable for diagnosing acute infection or estimating its prevalence during an outbreak. In addition, our findings show that MERS-CoV-IgG may not have significant value in determining disease severity or prognosis.
DOI: 10.1089/vim.2017.0091
PubMed: 28873020
Links to Exploration step
pubmed:28873020Le document en format XML
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Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Shakoor, Zahid" sort="Shakoor, Zahid" uniqKey="Shakoor Z" first="Zahid" last="Shakoor">Zahid Shakoor</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Mohamed, Deqa" sort="Mohamed, Deqa" uniqKey="Mohamed D" first="Deqa" last="Mohamed">Deqa Mohamed</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="El Hazmi, Malak" sort="El Hazmi, Malak" uniqKey="El Hazmi M" first="Malak" last="El-Hazmi">Malak El-Hazmi</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Somily, Ali" sort="Somily, Ali" uniqKey="Somily A" first="Ali" last="Somily">Ali Somily</name><affiliation><nlm:affiliation>1 King Khalid University 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Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Albarrag, Ahmed" sort="Albarrag, Ahmed" uniqKey="Albarrag A" first="Ahmed" last="Albarrag">Ahmed Albarrag</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Shakoor, Zahid" sort="Shakoor, Zahid" uniqKey="Shakoor Z" first="Zahid" last="Shakoor">Zahid Shakoor</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Mohamed, Deqa" sort="Mohamed, Deqa" uniqKey="Mohamed D" first="Deqa" last="Mohamed">Deqa Mohamed</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="El Hazmi, Malak" sort="El Hazmi, Malak" uniqKey="El Hazmi M" first="Malak" last="El-Hazmi">Malak El-Hazmi</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Somily, Ali" sort="Somily, Ali" uniqKey="Somily A" first="Ali" last="Somily">Ali Somily</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Barry, Mazin" sort="Barry, Mazin" uniqKey="Barry M" first="Mazin" last="Barry">Mazin Barry</name><affiliation><nlm:affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Bakhrebah, Muhammed" sort="Bakhrebah, Muhammed" uniqKey="Bakhrebah M" first="Muhammed" last="Bakhrebah">Muhammed Bakhrebah</name><affiliation><nlm:affiliation>4 King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author><author><name sortKey="Nassar, Majed" sort="Nassar, Majed" uniqKey="Nassar M" first="Majed" last="Nassar">Majed Nassar</name><affiliation><nlm:affiliation>4 King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia .</nlm:affiliation></affiliation></author></analytic><series><title level="j">Viral immunology</title><idno type="eISSN">1557-8976</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (blood)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza B virus (immunology)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (immunology)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Prognosis</term><term>RNA, Viral (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza B virus</term><term>Influenza, Human</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Prognosis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before. All underwent MERS-CoV RNA and MERS-CoV-IgG testing. Thirty patients were found to be MERS-CoV RNA positive; however, during serological analysis, only 6 (3.4%) patients were positive for MERS-CoV-IgG, 1 (0.6%) patient was equivocal, and 167 (96%) patients were negative. Among the serological positives, four were recently MERS-CoV RNA positive and two were MERS-CoV RNA negative. No cross-reactivity to influenza A or B was detected. Based on the lack of correlation between nucleic acid and serological analysis, we conclude that MERS-CoV-IgG testing may not be suitable for diagnosing acute infection or estimating its prevalence during an outbreak. In addition, our findings show that MERS-CoV-IgG may not have significant value in determining disease severity or prognosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28873020</PMID><DateCompleted><Year>2018</Year><Month>09</Month><Day>18</Day></DateCompleted><DateRevised><Year>2018</Year><Month>09</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8976</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>9</Issue><PubDate><Year>2017</Year><Month>11</Month></PubDate></JournalIssue><Title>Viral immunology</Title><ISOAbbreviation>Viral Immunol.</ISOAbbreviation></Journal><ArticleTitle>Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.</ArticleTitle><Pagination><MedlinePgn>649-653</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/vim.2017.0091</ELocationID><Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspected and proven cases of MERS-CoV infection. We enrolled 174 patients: 113 had respiratory symptoms/suspected MERS-CoV infection, 31 had confirmed influenza A or B infection, 23 had a recent confirmed MERS-CoV infection, and 7 had confirmed MERS-CoV infection 1 year before. All underwent MERS-CoV RNA and MERS-CoV-IgG testing. Thirty patients were found to be MERS-CoV RNA positive; however, during serological analysis, only 6 (3.4%) patients were positive for MERS-CoV-IgG, 1 (0.6%) patient was equivocal, and 167 (96%) patients were negative. Among the serological positives, four were recently MERS-CoV RNA positive and two were MERS-CoV RNA negative. No cross-reactivity to influenza A or B was detected. Based on the lack of correlation between nucleic acid and serological analysis, we conclude that MERS-CoV-IgG testing may not be suitable for diagnosing acute infection or estimating its prevalence during an outbreak. In addition, our findings show that MERS-CoV-IgG may not have significant value in determining disease severity or prognosis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alhetheel</LastName><ForeName>Abdulkarim</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2 Department of Pathology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Altalhi</LastName><ForeName>Haifa</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>3 Department of Infectious Diseases, College of Medicine, King Saud University , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albarrag</LastName><ForeName>Ahmed</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2 Department of Pathology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shakoor</LastName><ForeName>Zahid</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2 Department of Pathology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohamed</LastName><ForeName>Deqa</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Hazmi</LastName><ForeName>Malak</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2 Department of Pathology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Somily</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2 Department of Pathology, College of Medicine, King Saud University , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barry</LastName><ForeName>Mazin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1 King Khalid University Hospital , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>3 Department of Infectious Diseases, College of Medicine, King Saud University , Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bakhrebah</LastName><ForeName>Muhammed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>4 King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nassar</LastName><ForeName>Majed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>4 King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia .</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Viral Immunol</MedlineTA><NlmUniqueID>8801552</NlmUniqueID><ISSNLinking>0882-8245</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Viral Immunol. 2017 Dec;30(10 ):744</RefSource><PMID Version="1">29058554</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">MERS diagnostic testing</Keyword><Keyword MajorTopicYN="Y">MERS-CoV RNA</Keyword><Keyword MajorTopicYN="Y">MERS-CoV-IgG</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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