Curation
Accueil
Racine
Curation
Exploration
Accueil
Racine
Accueil
Racine

Serveur d'exploration MERS

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Halting coronavirus polymerase.

Identifieur interne : 000188 ( Main/Curation ); précédent : 000187; suivant : 000189

Halting coronavirus polymerase.

Auteurs : Robert N. Kirchdoerfer [États-Unis]

Source :

RBID : pubmed:32277065

Abstract

The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.

DOI: 10.1074/jbc.H120.013397
PubMed: 32277065

Links toward previous steps (curation, corpus...)

Links to Exploration step

pubmed:32277065

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Halting coronavirus polymerase.</title>
<author>
<name sortKey="Kirchdoerfer, Robert N" sort="Kirchdoerfer, Robert N" uniqKey="Kirchdoerfer R" first="Robert N" last="Kirchdoerfer">Robert N. Kirchdoerfer</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 rnkirchdoerf@wisc.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, University of Wisconsin-Madison, Madison</wicri:regionArea>
<wicri:noRegion>Madison</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32277065</idno>
<idno type="pmid">32277065</idno>
<idno type="doi">10.1074/jbc.H120.013397</idno>
<idno type="wicri:Area/PubMed/Corpus">000052</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000052</idno>
<idno type="wicri:Area/PubMed/Curation">000052</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000052</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000189</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000189</idno>
<idno type="wicri:Area/Ncbi/Merge">002739</idno>
<idno type="wicri:Area/Ncbi/Curation">002739</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002739</idno>
<idno type="wicri:Area/Main/Merge">000191</idno>
<idno type="wicri:Area/Main/Curation">000188</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Halting coronavirus polymerase.</title>
<author>
<name sortKey="Kirchdoerfer, Robert N" sort="Kirchdoerfer, Robert N" uniqKey="Kirchdoerfer R" first="Robert N" last="Kirchdoerfer">Robert N. Kirchdoerfer</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 rnkirchdoerf@wisc.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, University of Wisconsin-Madison, Madison</wicri:regionArea>
<wicri:noRegion>Madison</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">The Journal of biological chemistry</title>
<idno type="eISSN">1083-351X</idno>
<imprint>
<date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon
<i>et al.</i>
identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000188 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000188 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:32277065
   |texte=   Halting coronavirus polymerase.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i   -Sk "pubmed:32277065" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1
Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021