Halting coronavirus polymerase.
Identifieur interne : 000052 ( PubMed/Curation ); précédent : 000051; suivant : 000053Halting coronavirus polymerase.
Auteurs : Robert N. Kirchdoerfer [États-Unis]Source :
- The Journal of biological chemistry [ 1083-351X ] ; 2020.
Abstract
The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.
DOI: 10.1074/jbc.H120.013397
PubMed: 32277065
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<front><div type="abstract" xml:lang="en">The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon <i>et al.</i>
identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.</div>
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