MersV1, PubMed, Corpus, bibRecord, 000052

Halting coronavirus polymerase.

Identifieur interne : 000052 ( PubMed/Corpus ); précédent : 000051; suivant : 000053

Halting coronavirus polymerase.

Source :

The Journal of biological chemistry [ 1083-351X ] ; 2020.

RBID : pubmed:32277065

Abstract

The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.

DOI: 10.1074/jbc.H120.013397
PubMed: 32277065

Links to Exploration step

pubmed:32277065

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Halting coronavirus polymerase.</title>
<author><name sortKey="Kirchdoerfer, Robert N" sort="Kirchdoerfer, Robert N" uniqKey="Kirchdoerfer R" first="Robert N" last="Kirchdoerfer">Robert N. Kirchdoerfer</name>
<affiliation><nlm:affiliation>Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 rnkirchdoerf@wisc.edu.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32277065</idno>
<idno type="pmid">32277065</idno>
<idno type="doi">10.1074/jbc.H120.013397</idno>
<idno type="wicri:Area/PubMed/Corpus">000052</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000052</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Halting coronavirus polymerase.</title>
<author><name sortKey="Kirchdoerfer, Robert N" sort="Kirchdoerfer, Robert N" uniqKey="Kirchdoerfer R" first="Robert N" last="Kirchdoerfer">Robert N. Kirchdoerfer</name>
<affiliation><nlm:affiliation>Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 rnkirchdoerf@wisc.edu.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of biological chemistry</title>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon <i>et al.</i>
 identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32277065</PMID>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1083-351X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>295</Volume>
<Issue>15</Issue>
<PubDate><Year>2020</Year>
<Month>Apr</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of biological chemistry</Title>
<ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation>
</Journal>
<ArticleTitle>Halting coronavirus polymerase.</ArticleTitle>
<Pagination><MedlinePgn>4780-4781</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1074/jbc.H120.013397</ELocationID>
<Abstract><AbstractText>The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon <i>et al.</i>
 identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.</AbstractText>
<CopyrightInformation>© 2020 Kirchdoerfer.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kirchdoerfer</LastName>
<ForeName>Robert N</ForeName>
<Initials>RN</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-5974-2709</Identifier>
<AffiliationInfo><Affiliation>Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 rnkirchdoerf@wisc.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>K99 AI123498</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R00 AI123498</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Biol Chem</MedlineTA>
<NlmUniqueID>2985121R</NlmUniqueID>
<ISSNLinking>0021-9258</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>4</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32277065</ArticleId>
<ArticleId IdType="pii">295/15/4780</ArticleId>
<ArticleId IdType="doi">10.1074/jbc.H120.013397</ArticleId>
<ArticleId IdType="pmc">PMC7152748</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Sci Transl Med. 2017 Jun 28;9(396):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28659436</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Rep. 2017 Mar 06;7:43395</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28262699</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Commun. 2019 May 28;10(1):2342</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31138817</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>mBio. 2018 Mar 6;9(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29511076</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2020 Apr 10;295(15):4773-4779</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32094225</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2016 Mar 17;531(7594):381-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26934220</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2013 Aug;9(8):e1003565</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23966862</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virus Res. 2017 Apr 15;234:58-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28174054</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3900-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25197083</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618764483</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29562753</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000052 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000052 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:32277065
   |texte=   Halting coronavirus polymerase.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:32277065" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Halting coronavirus polymerase.

Halting coronavirus polymerase.

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki