Human papillomavirus infection in Norwegian women with cervical cancer
Identifieur interne : 000F03 ( Istex/Curation ); précédent : 000F02; suivant : 000F04Human papillomavirus infection in Norwegian women with cervical cancer
Auteurs : Ewy Kristiansen [Norvège] ; Andrew Jenkins [Norvège] ; Gunnar Kristensen [Norvège] ; Eirik Ask [Norvège] ; Janne K Rn [Norvège] ; Vera Abeler [Norvège] ; Bj Rn H. Lindqvist [Norvège] ; Claes Tropé [Norvège] ; Bj Rn-Erik Kristiansen [Norvège]Source :
- APMIS [ 0903-4641 ] ; 1994-01.
English descriptors
- Teeft :
- Adenocarcinoma, Adenosquamous carcinoma, Adenosquamous carcinomas, Andrew jenkins, Antisense strand, Band pattern, Biopsy, Blot, Cancer biopsies, Carcinoma, Cervical, Cervical biopsies, Cervical cancer, Cervical cancer biopsies, Cervical cancers, Cervical carcinomas, Gene targetted, Generic primers, Higgins, Histological examination, Hpvx, Human lymphocyte, Human papillomavirus, Human papillomavirus type, Hybridization, Kristiansen, Norway, Norwegian, Norwegian radium hospital, Norwegian women, Oligonucleotide probes, Other studies, Papillomavirus, Polymerase chain reaction, Poor prognosis, Poorer prognosis, Present study, Primer, Primer sequences, Sense strand, Significant association, Southern blot, Southern blot hybridisation, Southern blot hybridization, Type determinations, Unknown type, Uterine cervix.
Abstract
The objective of the present study was to determine the prevalence of human papillomavirus (HPV) infections in Norwegian women with cervical cancer. We used the polymerase chain reaction (PCR) and Southern blot techniques to assess the prevalence of HPV in cervical biopsies of 133 women admitted to the Norwegian Radium Hospital for treatment of cervical cancer. At the time of sampling (from February 1988 to April 1989) about 85% of Norwegian women with cervical cancer were treated at the Norwegian Radium Hospital. HPV was found in biopsies of 91 (68%) of women with cancer; 70 (53%) biopsies contained HPV type 16, 19 (14%) HPV type 18, 4 (3%) HPV type 33, 2 (1.5%) HPV type 11, and 3 (2%) HPV DNA of unknown type (HPVX). Five percent of biopsies were doubly infected, chiefly with HPV 16 + 18. We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.
Url:
DOI: 10.1111/j.1699-0463.1994.tb04856.x
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Lindqvist</name><affiliation wicri:level="1"><mods:affiliation>Department of Molecular Cell Biology, Institute of Biology, University of Oslo, Blindern, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Molecular Cell Biology, Institute of Biology, University of Oslo, Blindern</wicri:regionArea></affiliation></author><author><name sortKey="Trope, Claes" sort="Trope, Claes" uniqKey="Trope C" first="Claes" last="Tropé">Claes Tropé</name><affiliation wicri:level="1"><mods:affiliation>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Kristiansen, Bj Rn Rik" sort="Kristiansen, Bj Rn Rik" uniqKey="Kristiansen B" first="Bj Rn-Erik" last="Kristiansen">Bj Rn-Erik Kristiansen</name><affiliation wicri:level="1"><mods:affiliation>Telemark Biomedical Center, A/S Telelab, Skien, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Telemark Biomedical Center, A/S Telelab, Skien</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">APMIS</title><title level="j" type="alt">APMIS</title><idno type="ISSN">0903-4641</idno><idno type="eISSN">1600-0463</idno><imprint><biblScope unit="vol">102</biblScope><biblScope unit="issue">1‐6</biblScope><biblScope unit="page" from="122">122</biblScope><biblScope unit="page" to="128">128</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-01">1994-01</date></imprint><idno type="ISSN">0903-4641</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0903-4641</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenocarcinoma</term><term>Adenosquamous carcinoma</term><term>Adenosquamous carcinomas</term><term>Andrew jenkins</term><term>Antisense strand</term><term>Band pattern</term><term>Biopsy</term><term>Blot</term><term>Cancer biopsies</term><term>Carcinoma</term><term>Cervical</term><term>Cervical biopsies</term><term>Cervical cancer</term><term>Cervical cancer biopsies</term><term>Cervical cancers</term><term>Cervical carcinomas</term><term>Gene targetted</term><term>Generic primers</term><term>Higgins</term><term>Histological examination</term><term>Hpvx</term><term>Human lymphocyte</term><term>Human papillomavirus</term><term>Human papillomavirus type</term><term>Hybridization</term><term>Kristiansen</term><term>Norway</term><term>Norwegian</term><term>Norwegian radium hospital</term><term>Norwegian women</term><term>Oligonucleotide probes</term><term>Other studies</term><term>Papillomavirus</term><term>Polymerase chain reaction</term><term>Poor prognosis</term><term>Poorer prognosis</term><term>Present study</term><term>Primer</term><term>Primer sequences</term><term>Sense strand</term><term>Significant association</term><term>Southern blot</term><term>Southern blot hybridisation</term><term>Southern blot hybridization</term><term>Type determinations</term><term>Unknown type</term><term>Uterine cervix</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of the present study was to determine the prevalence of human papillomavirus (HPV) infections in Norwegian women with cervical cancer. We used the polymerase chain reaction (PCR) and Southern blot techniques to assess the prevalence of HPV in cervical biopsies of 133 women admitted to the Norwegian Radium Hospital for treatment of cervical cancer. At the time of sampling (from February 1988 to April 1989) about 85% of Norwegian women with cervical cancer were treated at the Norwegian Radium Hospital. HPV was found in biopsies of 91 (68%) of women with cancer; 70 (53%) biopsies contained HPV type 16, 19 (14%) HPV type 18, 4 (3%) HPV type 33, 2 (1.5%) HPV type 11, and 3 (2%) HPV DNA of unknown type (HPVX). Five percent of biopsies were doubly infected, chiefly with HPV 16 + 18. We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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