Human papillomavirus infection in Norwegian women with cervical cancer
Identifieur interne : 000F03 ( Istex/Corpus ); précédent : 000F02; suivant : 000F04Human papillomavirus infection in Norwegian women with cervical cancer
Auteurs : Ewy Kristiansen ; Andrew Jenkins ; Gunnar Kristensen ; Eirik Ask ; Janne K Rn ; Vera Abeler ; Bj Rn H. Lindqvist ; Claes Tropé ; Bj Rn-Erik KristiansenSource :
- APMIS [ 0903-4641 ] ; 1994-01.
English descriptors
- Teeft :
- Adenocarcinoma, Adenosquamous carcinoma, Adenosquamous carcinomas, Andrew jenkins, Antisense strand, Band pattern, Biopsy, Blot, Cancer biopsies, Carcinoma, Cervical, Cervical biopsies, Cervical cancer, Cervical cancer biopsies, Cervical cancers, Cervical carcinomas, Gene targetted, Generic primers, Higgins, Histological examination, Hpvx, Human lymphocyte, Human papillomavirus, Human papillomavirus type, Hybridization, Kristiansen, Norway, Norwegian, Norwegian radium hospital, Norwegian women, Oligonucleotide probes, Other studies, Papillomavirus, Polymerase chain reaction, Poor prognosis, Poorer prognosis, Present study, Primer, Primer sequences, Sense strand, Significant association, Southern blot, Southern blot hybridisation, Southern blot hybridization, Type determinations, Unknown type, Uterine cervix.
Abstract
The objective of the present study was to determine the prevalence of human papillomavirus (HPV) infections in Norwegian women with cervical cancer. We used the polymerase chain reaction (PCR) and Southern blot techniques to assess the prevalence of HPV in cervical biopsies of 133 women admitted to the Norwegian Radium Hospital for treatment of cervical cancer. At the time of sampling (from February 1988 to April 1989) about 85% of Norwegian women with cervical cancer were treated at the Norwegian Radium Hospital. HPV was found in biopsies of 91 (68%) of women with cancer; 70 (53%) biopsies contained HPV type 16, 19 (14%) HPV type 18, 4 (3%) HPV type 33, 2 (1.5%) HPV type 11, and 3 (2%) HPV DNA of unknown type (HPVX). Five percent of biopsies were doubly infected, chiefly with HPV 16 + 18. We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.
Url:
DOI: 10.1111/j.1699-0463.1994.tb04856.x
Links to Exploration step
ISTEX:4FD2AB1C1041EC29879EEE12AE20576B89191ABBLe document en format XML
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Lindqvist</name><affiliation><mods:affiliation>Department of Molecular Cell Biology, Institute of Biology, University of Oslo, Blindern, Norway</mods:affiliation></affiliation></author><author><name sortKey="Trope, Claes" sort="Trope, Claes" uniqKey="Trope C" first="Claes" last="Tropé">Claes Tropé</name><affiliation><mods:affiliation>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</mods:affiliation></affiliation></author><author><name sortKey="Kristiansen, Bj Rn Rik" sort="Kristiansen, Bj Rn Rik" uniqKey="Kristiansen B" first="Bj Rn-Erik" last="Kristiansen">Bj Rn-Erik Kristiansen</name><affiliation><mods:affiliation>Telemark Biomedical Center, A/S Telelab, Skien, Norway</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">APMIS</title><title level="j" type="alt">APMIS</title><idno type="ISSN">0903-4641</idno><idno type="eISSN">1600-0463</idno><imprint><biblScope unit="vol">102</biblScope><biblScope unit="issue">1‐6</biblScope><biblScope unit="page" from="122">122</biblScope><biblScope unit="page" to="128">128</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-01">1994-01</date></imprint><idno type="ISSN">0903-4641</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0903-4641</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenocarcinoma</term><term>Adenosquamous carcinoma</term><term>Adenosquamous carcinomas</term><term>Andrew jenkins</term><term>Antisense strand</term><term>Band pattern</term><term>Biopsy</term><term>Blot</term><term>Cancer biopsies</term><term>Carcinoma</term><term>Cervical</term><term>Cervical biopsies</term><term>Cervical cancer</term><term>Cervical cancer biopsies</term><term>Cervical cancers</term><term>Cervical carcinomas</term><term>Gene targetted</term><term>Generic primers</term><term>Higgins</term><term>Histological examination</term><term>Hpvx</term><term>Human lymphocyte</term><term>Human papillomavirus</term><term>Human papillomavirus type</term><term>Hybridization</term><term>Kristiansen</term><term>Norway</term><term>Norwegian</term><term>Norwegian radium hospital</term><term>Norwegian women</term><term>Oligonucleotide probes</term><term>Other studies</term><term>Papillomavirus</term><term>Polymerase chain reaction</term><term>Poor prognosis</term><term>Poorer prognosis</term><term>Present study</term><term>Primer</term><term>Primer sequences</term><term>Sense strand</term><term>Significant association</term><term>Southern blot</term><term>Southern blot hybridisation</term><term>Southern blot hybridization</term><term>Type determinations</term><term>Unknown type</term><term>Uterine cervix</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of the present study was to determine the prevalence of human papillomavirus (HPV) infections in Norwegian women with cervical cancer. We used the polymerase chain reaction (PCR) and Southern blot techniques to assess the prevalence of HPV in cervical biopsies of 133 women admitted to the Norwegian Radium Hospital for treatment of cervical cancer. At the time of sampling (from February 1988 to April 1989) about 85% of Norwegian women with cervical cancer were treated at the Norwegian Radium Hospital. HPV was found in biopsies of 91 (68%) of women with cancer; 70 (53%) biopsies contained HPV type 16, 19 (14%) HPV type 18, 4 (3%) HPV type 33, 2 (1.5%) HPV type 11, and 3 (2%) HPV DNA of unknown type (HPVX). Five percent of biopsies were doubly infected, chiefly with HPV 16 + 18. We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>cervical</json:string><json:string>cervical cancer</json:string><json:string>primer</json:string><json:string>papillomavirus</json:string><json:string>southern blot</json:string><json:string>hybridization</json:string><json:string>kristiansen</json:string><json:string>adenocarcinoma</json:string><json:string>human papillomavirus</json:string><json:string>hpvx</json:string><json:string>norwegian women</json:string><json:string>higgins</json:string><json:string>cervical cancers</json:string><json:string>carcinoma</json:string><json:string>biopsy</json:string><json:string>polymerase chain reaction</json:string><json:string>norwegian radium hospital</json:string><json:string>cancer biopsies</json:string><json:string>norwegian</json:string><json:string>southern blot hybridization</json:string><json:string>significant association</json:string><json:string>generic primers</json:string><json:string>unknown type</json:string><json:string>cervical cancer biopsies</json:string><json:string>cervical carcinomas</json:string><json:string>human papillomavirus type</json:string><json:string>norway</json:string><json:string>uterine cervix</json:string><json:string>andrew jenkins</json:string><json:string>primer sequences</json:string><json:string>human lymphocyte</json:string><json:string>type determinations</json:string><json:string>oligonucleotide probes</json:string><json:string>sense strand</json:string><json:string>antisense strand</json:string><json:string>poorer prognosis</json:string><json:string>southern blot hybridisation</json:string><json:string>adenosquamous carcinomas</json:string><json:string>histological examination</json:string><json:string>band pattern</json:string><json:string>gene targetted</json:string><json:string>present study</json:string><json:string>poor prognosis</json:string><json:string>cervical biopsies</json:string><json:string>adenosquamous carcinoma</json:string><json:string>other studies</json:string><json:string>blot</json:string></teeft></keywords><author><json:item><name>EWY Kristiansen</name><affiliations><json:string>Telemark Biomedical Center, A/S Telelab, Skien, Norway</json:string></affiliations></json:item><json:item><name>ANDREW Jenkins</name><affiliations><json:string>Telemark Biomedical Center, A/S Telelab, Skien, Norway</json:string><json:string>Correspondence address: A/S Telelab, PO Box 1868 Gulset, N‐3705 Skien, Norway.</json:string></affiliations></json:item><json:item><name>GUNNAR Kristensen</name><affiliations><json:string>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</json:string></affiliations></json:item><json:item><name>EIRIK Ask</name><affiliations><json:string>Telemark Biomedical Center, A/S Telelab, Skien, Norway</json:string></affiliations></json:item><json:item><name>JANNE KæRn</name><affiliations><json:string>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</json:string></affiliations></json:item><json:item><name>VERA Abeler</name><affiliations><json:string>Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</json:string></affiliations></json:item><json:item><name>BJØRN H. Lindqvist</name><affiliations><json:string>Department of Molecular Cell Biology, Institute of Biology, University of Oslo, Blindern, Norway</json:string></affiliations></json:item><json:item><name>CLAES TropÉ</name><affiliations><json:string>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</json:string></affiliations></json:item><json:item><name>BJØRN‐ERIK Kristiansen</name><affiliations><json:string>Telemark Biomedical Center, A/S Telelab, Skien, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>HPV</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HPV 18</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cervical cancer</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCR</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>adenocarcinoma</value></json:item></subject><articleId><json:string>APM4856</json:string></articleId><arkIstex>ark:/67375/WNG-240VMDG2-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The objective of the present study was to determine the prevalence of human papillomavirus (HPV) infections in Norwegian women with cervical cancer. We used the polymerase chain reaction (PCR) and Southern blot techniques to assess the prevalence of HPV in cervical biopsies of 133 women admitted to the Norwegian Radium Hospital for treatment of cervical cancer. At the time of sampling (from February 1988 to April 1989) about 85% of Norwegian women with cervical cancer were treated at the Norwegian Radium Hospital. HPV was found in biopsies of 91 (68%) of women with cancer; 70 (53%) biopsies contained HPV type 16, 19 (14%) HPV type 18, 4 (3%) HPV type 33, 2 (1.5%) HPV type 11, and 3 (2%) HPV DNA of unknown type (HPVX). Five percent of biopsies were doubly infected, chiefly with HPV 16 + 18. We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.</abstract><qualityIndicators><score>8.615</score><pdfWordCount>3747</pdfWordCount><pdfCharCount>22093</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>570.96 x 784.2 pts</pdfPageSize><pdfWordsPerPage>535</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>239</abstractWordCount><abstractCharCount>1442</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Human papillomavirus infection in Norwegian women with cervical cancer</title><genre><json:string>article</json:string></genre><host><title>APMIS</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0463</json:string></doi><issn><json:string>0903-4641</json:string></issn><eissn><json:string>1600-0463</json:string></eissn><publisherId><json:string>APM</json:string></publisherId><volume>102</volume><issue>1‐6</issue><pages><first>122</first><last>128</last><total>7</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1994</json:string><json:string>1983</json:string><json:string>from February 1988 to April 1989</json:string></date><geogName></geogName><orgName><json:string>Biotech, Colchester, UK</json:string><json:string>Department of Molecular Cell Biology, Institute of Biology, University of Oslo, Blindern, Norway Kristiansen</json:string><json:string>Paterson Institute, Manchester</json:string><json:string>University of Oslo</json:string><json:string>Oslo Biotechnology Center</json:string><json:string>Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</json:string><json:string>Institute Pasteur, Paris, France</json:string><json:string>Amersham International</json:string><json:string>Department of Gynecologic Oncology</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>John Arrand</json:string><json:string>Andrew Jenkins</json:string></persName><placeName><json:string>Uppsala</json:string><json:string>NORWAY</json:string><json:string>UK</json:string><json:string>Norway</json:string><json:string>Richmond</json:string><json:string>Skien</json:string><json:string>USA</json:string><json:string>CA</json:string><json:string>Sweden</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Riou et al. 1990</json:string><json:string>Walker et al. 1989</json:string><json:string>Tham et al. (1991)</json:string><json:string>Poulson di Taylor 1975</json:string><json:string>Kristiansen et al.</json:string><json:string>Higgins et al.</json:string><json:string>Higgins et al. 1991</json:string><json:string>Melchers et al. (1989)</json:string><json:string>Kristiansen et al</json:string><json:string>Higgins et al. (1991)</json:string><json:string>Woodworth et al. 1990</json:string><json:string>Barnes et al. 1990</json:string><json:string>Beaudenon et al. 1987</json:string><json:string>Wilczynski et al. 1988</json:string><json:string>Maniatis et al. 1982</json:string><json:string>Barnes et al. 1988</json:string><json:string>Sebbelov et al.</json:string><json:string>Jenkins et al. 1991</json:string><json:string>Riou et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-240VMDG2-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pathology</json:string><json:string>2 - microbiology</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - oncology & carcinogenesis</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - 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We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">HPV</term><term xml:id="k2">HPV 18</term><term xml:id="k3">cervical cancer</term><term xml:id="k4">PCR</term><term xml:id="k5">adenocarcinoma</term></keywords><keywords rend="tocHeading1"><term>Original Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-240VMDG2-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0463</doi><issn type="print">0903-4641</issn><issn type="electronic">1600-0463</issn><idGroup><id type="product" value="APM"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="APMIS">APMIS</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/apm.1994.102.issue-1-6</doi><numberingGroup><numbering type="journalVolume" number="102">102</numbering><numbering type="journalIssue">1‐6</numbering></numberingGroup><coverDate startDate="1994-01">January 1994</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="19" status="forIssue"><doi origin="wiley">10.1111/j.1699-0463.1994.tb04856.x</doi><idGroup><id type="unit" value="APM4856"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><copyright>1994 Acta Pathologica, Microbiologica et Immunologica Scandinavica</copyright><eventGroup><event type="firstOnline" date="2009-08-15"></event><event type="publishedOnlineFinalForm" date="2009-08-15"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:HeaderRef result:HeaderRef" date="2010-04-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-04"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="122">122</numbering><numbering type="pageLast" number="128">128</numbering></numberingGroup><correspondenceTo>A/S Telelab, PO Box 1868 Gulset, N‐3705 Skien, Norway.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:APM.APM4856.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received August 2, 1993. Accepted November 25, 1993.</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="19"></count><count type="linksCrossRef" number="11"></count></countGroup><titleGroup><title type="main">Human papillomavirus infection in Norwegian women with cervical cancer</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>EWY</givenNames><familyName>Kristiansen</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1" corresponding="yes"><personName><givenNames>ANDREW</givenNames><familyName>Jenkins</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>GUNNAR</givenNames><familyName>Kristensen</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>EIRIK</givenNames><familyName>Ask</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>JANNE</givenNames><familyName>KæRn</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a3"><personName><givenNames>VERA</givenNames><familyName>Abeler</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a4"><personName><givenNames>BJØRN H.</givenNames><familyName>Lindqvist</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a2"><personName><givenNames>CLAES</givenNames><familyName>TropÉ</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>BJØRN‐ERIK</givenNames><familyName>Kristiansen</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="NO"><unparsedAffiliation>Telemark Biomedical Center, A/S Telelab, Skien, Norway</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="NO"><unparsedAffiliation>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="NO"><unparsedAffiliation>Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="NO"><unparsedAffiliation>Department of Molecular Cell Biology, Institute of Biology, University of Oslo, Blindern, Norway</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">HPV</keyword><keyword xml:id="k2">HPV 18</keyword><keyword xml:id="k3">cervical cancer</keyword><keyword xml:id="k4">PCR</keyword><keyword xml:id="k5">adenocarcinoma</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>The objective of the present study was to determine the prevalence of human papillomavirus (HPV) infections in Norwegian women with cervical cancer. We used the polymerase chain reaction (PCR) and Southern blot techniques to assess the prevalence of HPV in cervical biopsies of 133 women admitted to the Norwegian Radium Hospital for treatment of cervical cancer. At the time of sampling (from February 1988 to April 1989) about 85% of Norwegian women with cervical cancer were treated at the Norwegian Radium Hospital. HPV was found in biopsies of 91 (68%) of women with cancer; 70 (53%) biopsies contained HPV type 16, 19 (14%) HPV type 18, 4 (3%) HPV type 33, 2 (1.5%) HPV type 11, and 3 (2%) HPV DNA of unknown type (HPVX). Five percent of biopsies were doubly infected, chiefly with HPV 16 + 18. We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p>Norwegian Ministry of Health and Social Affairs, Pb 801 1, 0030 Oslo, Norway.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Human papillomavirus infection in Norwegian women with cervical cancer</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Human papillomavirus infection in Norwegian women with cervical cancer</title></titleInfo><name type="personal"><namePart type="given">EWY</namePart><namePart type="family">Kristiansen</namePart><affiliation>Telemark Biomedical Center, A/S Telelab, Skien, Norway</affiliation><description>Norwegian Ministry of Health and Social Affairs, Pb 801 1, 0030 Oslo, Norway.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ANDREW</namePart><namePart type="family">Jenkins</namePart><affiliation>Telemark Biomedical Center, A/S Telelab, Skien, Norway</affiliation><affiliation>Correspondence address: A/S Telelab, PO Box 1868 Gulset, N‐3705 Skien, Norway.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GUNNAR</namePart><namePart type="family">Kristensen</namePart><affiliation>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EIRIK</namePart><namePart type="family">Ask</namePart><affiliation>Telemark Biomedical Center, A/S Telelab, Skien, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JANNE</namePart><namePart type="family">KæRn</namePart><affiliation>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VERA</namePart><namePart type="family">Abeler</namePart><affiliation>Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BJØRN H.</namePart><namePart type="family">Lindqvist</namePart><affiliation>Department of Molecular Cell Biology, Institute of Biology, University of Oslo, Blindern, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CLAES</namePart><namePart type="family">TropÉ</namePart><affiliation>Department of Gynecologic Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BJØRN‐ERIK</namePart><namePart type="family">Kristiansen</namePart><affiliation>Telemark Biomedical Center, A/S Telelab, Skien, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1994-01</dateIssued><edition>Received August 2, 1993. Accepted November 25, 1993.</edition><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">19</extent><extent unit="linksCrossRef">11</extent></physicalDescription><abstract lang="en">The objective of the present study was to determine the prevalence of human papillomavirus (HPV) infections in Norwegian women with cervical cancer. We used the polymerase chain reaction (PCR) and Southern blot techniques to assess the prevalence of HPV in cervical biopsies of 133 women admitted to the Norwegian Radium Hospital for treatment of cervical cancer. At the time of sampling (from February 1988 to April 1989) about 85% of Norwegian women with cervical cancer were treated at the Norwegian Radium Hospital. HPV was found in biopsies of 91 (68%) of women with cancer; 70 (53%) biopsies contained HPV type 16, 19 (14%) HPV type 18, 4 (3%) HPV type 33, 2 (1.5%) HPV type 11, and 3 (2%) HPV DNA of unknown type (HPVX). Five percent of biopsies were doubly infected, chiefly with HPV 16 + 18. We found a significant association between HPV 18 and low age, poorly differentiated tumors and adenocarcinomas. Our results show that there is an association between HPV types 16 and 18 and cervical cancer also in a Norwegian setting. PCR was more sensitive than Southern blotting for detection of HPV. Thirty‐six (27.5%) of cancer biopsies were positive by PCR but negative by Southern blotting, as against 49 (73.5%) positive by both methods; we also encountered 4 samples positive by Southern blotting and negative by PCR. In 23/53 cancer biopsies positive by Southern blotting we found evidence for integrated or rearranged HPV genomes.</abstract><subject lang="en"><genre>keywords</genre><topic>HPV</topic><topic>HPV 18</topic><topic>cervical cancer</topic><topic>PCR</topic><topic>adenocarcinoma</topic></subject><relatedItem type="host"><titleInfo><title>APMIS</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0903-4641</identifier><identifier type="eISSN">1600-0463</identifier><identifier type="DOI">10.1111/(ISSN)1600-0463</identifier><identifier type="PublisherID">APM</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>102</number></detail><detail type="issue"><caption>no.</caption><number>1‐6</number></detail><extent unit="pages"><start>122</start><end>128</end><total>7</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Possible prognostic significance of human papillomavirus type in cervical cancer</title></titleInfo><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Barnes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Delgado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. 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Cancer Res. 50: 3709–3715, 1990.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>3709</start><end>3715</end></extent></part><relatedItem type="host"><titleInfo><title>Cancer Res.</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>3709</start><end>3715</end></extent></part></relatedItem></relatedItem><identifier type="istex">4FD2AB1C1041EC29879EEE12AE20576B89191ABB</identifier><identifier type="ark">ark:/67375/WNG-240VMDG2-R</identifier><identifier type="DOI">10.1111/j.1699-0463.1994.tb04856.x</identifier><identifier type="ArticleID">APM4856</identifier><accessCondition type="use and reproduction" contentType="copyright">1994 Acta Pathologica, Microbiologica et Immunologica Scandinavica</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-13</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-240VMDG2-R/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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