Chemoenzymatic synthesis, characterization, and controlled release of functional polymeric prodrugs with acyclovir as pendant
Identifieur interne : 000F02 ( Istex/Curation ); précédent : 000F01; suivant : 000F03Chemoenzymatic synthesis, characterization, and controlled release of functional polymeric prodrugs with acyclovir as pendant
Auteurs : Xia Li [République populaire de Chine] ; Qi Wu [République populaire de Chine] ; Fu Zhang [République populaire de Chine] ; Xian-Fu Lin [République populaire de Chine]Source :
- Journal of Applied Polymer Science [ 0021-8995 ] ; 2008-04-05.
Abstract
An efficient protocol for the synthesis of functional polymeric prodrugs of acyclovir with variable copolymer composition and potential liver‐targeting delivery was achieved by combining enzymatic selective synthesis of polymerizable acyclovir derivatives with radical copolymerization of properly selected comonomers. Vinyl D‐galactose ester (VAG), acrylic acid (AA), and methyl methacrylate (MMA) were chosen as comonomers and three novel polymeric prodrugs with acyclovir as pendant were synthesized using 2,2′‐azo‐bis‐iso‐butyronitrile (AIBN) as initiator in N,N‐dimethylformamide (DMF). The resulting polymers were characterized by FTIR, NMR, and GPC. The influence of the concentration of initiator and the molar ratio of comonomers on the polymerization was investigated. In vitro drug release studies showed that acyclovir could be released from poly(2‐N‐vinylsebacyl‐acyclovir‐co‐methyl methacrylate) (poly(VSA‐co‐MMA)), and the total released acyclovir after 7 days in buffer solution at pH 1.2 and 7.4 was ∼ 35% and 29%, respectively. Also, homopolymers of vinyl acyclovir derivatives with high drug payload (>50 wt %) were obtained and characterized by the same methods. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Url:
DOI: 10.1002/app.27680
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000F02
Links to Exploration step
ISTEX:24ADC09FD9E9A0100172235576F3CD611287A647Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chemoenzymatic synthesis, characterization, and controlled release of functional polymeric prodrugs with acyclovir as pendant</title>
<author><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wu, Qi" sort="Wu, Qi" uniqKey="Wu Q" first="Qi" last="Wu">Qi Wu</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Fu" sort="Zhang, Fu" uniqKey="Zhang F" first="Fu" last="Zhang">Fu Zhang</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lin, Xian U" sort="Lin, Xian U" uniqKey="Lin X" first="Xian-Fu" last="Lin">Xian-Fu Lin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: llc123@zju.edu.cn</mods:affiliation>
<country wicri:rule="url">République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence address: Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China===</mods:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Correspondence address: Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:24ADC09FD9E9A0100172235576F3CD611287A647</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/app.27680</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-R0VDQRR4-N/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000F02</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F02</idno>
<idno type="wicri:Area/Istex/Curation">000F02</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Chemoenzymatic synthesis, characterization, and controlled release of functional polymeric prodrugs with acyclovir as pendant</title>
<author><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wu, Qi" sort="Wu, Qi" uniqKey="Wu Q" first="Qi" last="Wu">Qi Wu</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Fu" sort="Zhang, Fu" uniqKey="Zhang F" first="Fu" last="Zhang">Fu Zhang</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lin, Xian U" sort="Lin, Xian U" uniqKey="Lin X" first="Xian-Fu" last="Lin">Xian-Fu Lin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China</mods:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: llc123@zju.edu.cn</mods:affiliation>
<country wicri:rule="url">République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence address: Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China===</mods:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Correspondence address: Department of Chemistry, Zhejiang University, Hangzhou 310027</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Applied Polymer Science</title>
<title level="j" type="alt">JOURNAL OF APPLIED POLYMER SCIENCE</title>
<idno type="ISSN">0021-8995</idno>
<idno type="eISSN">1097-4628</idno>
<imprint><biblScope unit="vol">108</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="431">431</biblScope>
<biblScope unit="page" to="437">437</biblScope>
<biblScope unit="page-count">7</biblScope>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-04-05">2008-04-05</date>
</imprint>
<idno type="ISSN">0021-8995</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0021-8995</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">An efficient protocol for the synthesis of functional polymeric prodrugs of acyclovir with variable copolymer composition and potential liver‐targeting delivery was achieved by combining enzymatic selective synthesis of polymerizable acyclovir derivatives with radical copolymerization of properly selected comonomers. Vinyl D‐galactose ester (VAG), acrylic acid (AA), and methyl methacrylate (MMA) were chosen as comonomers and three novel polymeric prodrugs with acyclovir as pendant were synthesized using 2,2′‐azo‐bis‐iso‐butyronitrile (AIBN) as initiator in N,N‐dimethylformamide (DMF). The resulting polymers were characterized by FTIR, NMR, and GPC. The influence of the concentration of initiator and the molar ratio of comonomers on the polymerization was investigated. In vitro drug release studies showed that acyclovir could be released from poly(2‐N‐vinylsebacyl‐acyclovir‐co‐methyl methacrylate) (poly(VSA‐co‐MMA)), and the total released acyclovir after 7 days in buffer solution at pH 1.2 and 7.4 was ∼ 35% and 29%, respectively. Also, homopolymers of vinyl acyclovir derivatives with high drug payload (>50 wt %) were obtained and characterized by the same methods. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F02 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000F02 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:24ADC09FD9E9A0100172235576F3CD611287A647 |texte= Chemoenzymatic synthesis, characterization, and controlled release of functional polymeric prodrugs with acyclovir as pendant }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |