Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides
Identifieur interne : 000130 ( Istex/Curation ); précédent : 000129; suivant : 000131Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides
Auteurs : Edwin M. Southern [Royaume-Uni] ; Uwe Maskos [Royaume-Uni]Source :
- Journal of Biotechnology [ 0168-1656 ] ; 1994.
English descriptors
- Teeft :
- Acad, Aliphatic linker, Amino acids, Appropriate base, Atomic force microscopy, Base pairs, Biotechnology, Capillary action, Cell size, Chemical synthesis, Complete sets, Digitised data, Duplex, Duplex stability, Glass plate, Glass plates, Hybridisation, Hybridisation data, Hybridization, Intensity values, International patent application, Large numbers, Ligand, Linker, Maskos, Maskos journal, Maximum entropy, Microscope slides, Multiple samples, Multiplex analysis, Natl, Next reagent, Novel method, Nucleic, Nucleic acid sequence analysis, Nucleic acids, Oligonucleotide, Oligonucleotide duplexes, Oligonucleotide synthesis, Oligonucleotides, Parallel analysis, Parallel synthesis, Peptide synthesis, Polymerase chain reaction, Pore size, Proc, Quantitative approach, Reagent, Same time, Sequence analysis, Sequence assembly, Sequencing, Sickle variant gene, Side chains, Single base substitutions, Solid phase synthesis, Solid support, Storage phosphor screen, Storage phosphor technology, Synthetic oligodeoxyribonucleotides, Tetrahedron lett, Tetramethylammonium chloride, Thermal stability.
Abstract
Abstract: This review presents methods for addressing the issue of molecular complexity in biological systems. Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. The specific embodiments of this new method are presented, research up to mid-1992 outlined and requirements for future development discussed.
Url:
DOI: 10.1016/0168-1656(94)90037-X
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Southern</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU</wicri:regionArea></affiliation></author><author><name sortKey="Maskos, Uwe" sort="Maskos, Uwe" uniqKey="Maskos U" first="Uwe" last="Maskos">Uwe Maskos</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Biotechnology</title><title level="j" type="abbrev">BIOTEC</title><idno type="ISSN">0168-1656</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="217">217</biblScope><biblScope unit="page" to="227">227</biblScope></imprint><idno type="ISSN">0168-1656</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0168-1656</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad</term><term>Aliphatic linker</term><term>Amino acids</term><term>Appropriate base</term><term>Atomic force microscopy</term><term>Base pairs</term><term>Biotechnology</term><term>Capillary action</term><term>Cell size</term><term>Chemical synthesis</term><term>Complete sets</term><term>Digitised data</term><term>Duplex</term><term>Duplex stability</term><term>Glass plate</term><term>Glass plates</term><term>Hybridisation</term><term>Hybridisation data</term><term>Hybridization</term><term>Intensity values</term><term>International patent application</term><term>Large numbers</term><term>Ligand</term><term>Linker</term><term>Maskos</term><term>Maskos journal</term><term>Maximum entropy</term><term>Microscope slides</term><term>Multiple samples</term><term>Multiplex analysis</term><term>Natl</term><term>Next reagent</term><term>Novel method</term><term>Nucleic</term><term>Nucleic acid sequence analysis</term><term>Nucleic acids</term><term>Oligonucleotide</term><term>Oligonucleotide duplexes</term><term>Oligonucleotide synthesis</term><term>Oligonucleotides</term><term>Parallel analysis</term><term>Parallel synthesis</term><term>Peptide synthesis</term><term>Polymerase chain reaction</term><term>Pore size</term><term>Proc</term><term>Quantitative approach</term><term>Reagent</term><term>Same time</term><term>Sequence analysis</term><term>Sequence assembly</term><term>Sequencing</term><term>Sickle variant gene</term><term>Side chains</term><term>Single base substitutions</term><term>Solid phase synthesis</term><term>Solid support</term><term>Storage phosphor screen</term><term>Storage phosphor technology</term><term>Synthetic oligodeoxyribonucleotides</term><term>Tetrahedron lett</term><term>Tetramethylammonium chloride</term><term>Thermal stability</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This review presents methods for addressing the issue of molecular complexity in biological systems. Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. The specific embodiments of this new method are presented, research up to mid-1992 outlined and requirements for future development discussed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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