Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides
Identifieur interne : 000130 ( Istex/Corpus ); précédent : 000129; suivant : 000131Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides
Auteurs : Edwin M. Southern ; Uwe MaskosSource :
- Journal of Biotechnology [ 0168-1656 ] ; 1994.
English descriptors
- Teeft :
- Acad, Aliphatic linker, Amino acids, Appropriate base, Atomic force microscopy, Base pairs, Biotechnology, Capillary action, Cell size, Chemical synthesis, Complete sets, Digitised data, Duplex, Duplex stability, Glass plate, Glass plates, Hybridisation, Hybridisation data, Hybridization, Intensity values, International patent application, Large numbers, Ligand, Linker, Maskos, Maskos journal, Maximum entropy, Microscope slides, Multiple samples, Multiplex analysis, Natl, Next reagent, Novel method, Nucleic, Nucleic acid sequence analysis, Nucleic acids, Oligonucleotide, Oligonucleotide duplexes, Oligonucleotide synthesis, Oligonucleotides, Parallel analysis, Parallel synthesis, Peptide synthesis, Polymerase chain reaction, Pore size, Proc, Quantitative approach, Reagent, Same time, Sequence analysis, Sequence assembly, Sequencing, Sickle variant gene, Side chains, Single base substitutions, Solid phase synthesis, Solid support, Storage phosphor screen, Storage phosphor technology, Synthetic oligodeoxyribonucleotides, Tetrahedron lett, Tetramethylammonium chloride, Thermal stability.
Abstract
Abstract: This review presents methods for addressing the issue of molecular complexity in biological systems. Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. The specific embodiments of this new method are presented, research up to mid-1992 outlined and requirements for future development discussed.
Url:
DOI: 10.1016/0168-1656(94)90037-X
Links to Exploration step
ISTEX:E9FDBD199591D2C4EC4FDEE857269DF3E53D2FC1Le document en format XML
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Southern</name><affiliation><mods:affiliation>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK</mods:affiliation></affiliation></author><author><name sortKey="Maskos, Uwe" sort="Maskos, Uwe" uniqKey="Maskos U" first="Uwe" last="Maskos">Uwe Maskos</name><affiliation><mods:affiliation>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Biotechnology</title><title level="j" type="abbrev">BIOTEC</title><idno type="ISSN">0168-1656</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="217">217</biblScope><biblScope unit="page" to="227">227</biblScope></imprint><idno type="ISSN">0168-1656</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0168-1656</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad</term><term>Aliphatic linker</term><term>Amino acids</term><term>Appropriate base</term><term>Atomic force microscopy</term><term>Base pairs</term><term>Biotechnology</term><term>Capillary action</term><term>Cell size</term><term>Chemical synthesis</term><term>Complete sets</term><term>Digitised data</term><term>Duplex</term><term>Duplex stability</term><term>Glass plate</term><term>Glass plates</term><term>Hybridisation</term><term>Hybridisation data</term><term>Hybridization</term><term>Intensity values</term><term>International patent application</term><term>Large numbers</term><term>Ligand</term><term>Linker</term><term>Maskos</term><term>Maskos journal</term><term>Maximum entropy</term><term>Microscope slides</term><term>Multiple samples</term><term>Multiplex analysis</term><term>Natl</term><term>Next reagent</term><term>Novel method</term><term>Nucleic</term><term>Nucleic acid sequence analysis</term><term>Nucleic acids</term><term>Oligonucleotide</term><term>Oligonucleotide duplexes</term><term>Oligonucleotide synthesis</term><term>Oligonucleotides</term><term>Parallel analysis</term><term>Parallel synthesis</term><term>Peptide synthesis</term><term>Polymerase chain reaction</term><term>Pore size</term><term>Proc</term><term>Quantitative approach</term><term>Reagent</term><term>Same time</term><term>Sequence analysis</term><term>Sequence assembly</term><term>Sequencing</term><term>Sickle variant gene</term><term>Side chains</term><term>Single base substitutions</term><term>Solid phase synthesis</term><term>Solid support</term><term>Storage phosphor screen</term><term>Storage phosphor technology</term><term>Synthetic oligodeoxyribonucleotides</term><term>Tetrahedron lett</term><term>Tetramethylammonium chloride</term><term>Thermal stability</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This review presents methods for addressing the issue of molecular complexity in biological systems. Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. 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Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. 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(1989)</json:string><json:string>Maskos and Southern, 1992a</json:string><json:string>Andrus et al., 1988</json:string><json:string>Southern, 1988</json:string><json:string>Tomie et al., 1991</json:string><json:string>Geysen et al., 1984</json:string><json:string>Fodor et al., 1991</json:string><json:string>Bains, 1991</json:string><json:string>Craig et al., 1991</json:string><json:string>Melchior and von Hippel, 1973</json:string><json:string>Myers et al.</json:string><json:string>Strezoska et al., 1991</json:string><json:string>Khrapko et al., 1991</json:string><json:string>Kurnit, 1979</json:string><json:string>Johnston et al., 1990</json:string><json:string>Lysov et al., 1988</json:string><json:string>Wallace et al., 1979</json:string><json:string>Maskos and Southern, 1993a, b</json:string><json:string>Elder, 1993</json:string><json:string>Botstein et al., 1980</json:string><json:string>Breslauer et al., 1986</json:string><json:string>Fodor et al. 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Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. The specific embodiments of this new method are presented, research up to mid-1992 outlined and requirements for future development discussed.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parallel synthesis</term></item><item><term>Solid phase synthesis</term></item><item><term>Biomolecule</term></item><item><term>Sequencing by hybridisation</term></item><item><term>Mutation detection</term></item><item><term>Multiplex analysis</term></item><item><term>Genotyping</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-813V9T8P-1/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>BIOTEC</jid><aid>9490037X</aid><ce:pii>0168-1656(94)90037-X</ce:pii><ce:doi>10.1016/0168-1656(94)90037-X</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:title>Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides</ce:title><ce:author-group><ce:author><ce:given-name>Edwin M.</ce:given-name><ce:surname>Southern</ce:surname></ce:author><ce:author><ce:given-name>Uwe</ce:given-name><ce:surname>Maskos</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author: Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>This review presents methods for addressing the issue of molecular complexity in biological systems. Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. The specific embodiments of this new method are presented, research up to mid-1992 outlined and requirements for future development discussed.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Parallel synthesis</ce:text></ce:keyword><ce:keyword><ce:text>Solid phase synthesis</ce:text></ce:keyword><ce:keyword><ce:text>Biomolecule</ce:text></ce:keyword><ce:keyword><ce:text>Sequencing by hybridisation</ce:text></ce:keyword><ce:keyword><ce:text>Mutation detection</ce:text></ce:keyword><ce:keyword><ce:text>Multiplex analysis</ce:text></ce:keyword><ce:keyword><ce:text>Genotyping</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides</title></titleInfo><name type="personal"><namePart type="given">Edwin M.</namePart><namePart type="family">Southern</namePart><affiliation>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Uwe</namePart><namePart type="family">Maskos</namePart><affiliation>Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK</affiliation><description>Corresponding author: Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: This review presents methods for addressing the issue of molecular complexity in biological systems. Biomolecules immobilised on solid phases can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. The specific embodiments of this new method are presented, research up to mid-1992 outlined and requirements for future development discussed.</abstract><subject><genre>Keywords</genre><topic>Parallel synthesis</topic><topic>Solid phase synthesis</topic><topic>Biomolecule</topic><topic>Sequencing by hybridisation</topic><topic>Mutation detection</topic><topic>Multiplex analysis</topic><topic>Genotyping</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Biotechnology</title></titleInfo><titleInfo type="abbreviated"><title>BIOTEC</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0168-1656</identifier><identifier type="PII">S0168-1656(00)X0159-9</identifier><part><date>1994</date><detail type="issue"><title>Genome Research/Molecular Biotechnology, Part I </title></detail><detail type="volume"><number>35</number><caption>vol.</caption></detail><detail type="issue"><number>2–3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>109</start><end>298</end></extent><extent unit="pages"><start>217</start><end>227</end></extent></part></relatedItem><identifier type="istex">E9FDBD199591D2C4EC4FDEE857269DF3E53D2FC1</identifier><identifier type="ark">ark:/67375/6H6-813V9T8P-1</identifier><identifier type="DOI">10.1016/0168-1656(94)90037-X</identifier><identifier type="PII">0168-1656(94)90037-X</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-813V9T8P-1/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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