The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection
Identifieur interne : 001111 ( Istex/Corpus ); précédent : 001110; suivant : 001112The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection
Auteurs : Nancy Linford ; Christian Wade ; Daniel DorsaSource :
- Journal of Neurocytology [ 0300-4864 ] ; 2000-05-01.
Abstract
Abstract: A review of the literature reveals an impressively broad spectrum of effects of the hormone estrogen in the CNS. One of the more recently documented is the ability of estrogen to protect neurons from cell death associated with a variety of insults. While some of these actions can be attributed to nuclear effects of the hormone, mediated by the estrogen receptors alpha and/or beta, an increasing number of these effects appear to result from actions of the hormone mediated by signal transduction pathways traditionally associated with activation of membrane receptors. Here, we review current findings on actions of estrogen mediated by two pathways: those dependent on cAMP and Protein Kinase A, and those related to activation of the Mitogen Acivated Protein Kinase cascade. The evidence that estrogen can rapidly activate either pathway, and the potential involvement of the estrogen receptors alpha or beta acting in the vicinity of the cell membrane will be discussed. The possible role of MAP-Kinase activation and BCL-2 induction in the phenomenon of estrogen-neuroprotection will also be addressed.
Url:
DOI: 10.1023/A:1007113323582
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One of the more recently documented is the ability of estrogen to protect neurons from cell death associated with a variety of insults. While some of these actions can be attributed to nuclear effects of the hormone, mediated by the estrogen receptors alpha and/or beta, an increasing number of these effects appear to result from actions of the hormone mediated by signal transduction pathways traditionally associated with activation of membrane receptors. Here, we review current findings on actions of estrogen mediated by two pathways: those dependent on cAMP and Protein Kinase A, and those related to activation of the Mitogen Acivated Protein Kinase cascade. The evidence that estrogen can rapidly activate either pathway, and the potential involvement of the estrogen receptors alpha or beta acting in the vicinity of the cell membrane will be discussed. The possible role of MAP-Kinase activation and BCL-2 induction in the phenomenon of estrogen-neuroprotection will also be addressed.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection</title></titleInfo><name type="personal"><namePart type="given">Nancy</namePart><namePart type="family">Linford</namePart><affiliation>Department of Pharmacology, University of Washington, 98195, Seattle, WA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christian</namePart><namePart type="family">Wade</namePart><affiliation>Department of Pharmacology, University of Washington, 98195, Seattle, WA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel</namePart><namePart type="family">Dorsa</namePart><affiliation>Department of Pharmacology, University of Washington, 98195, Seattle, WA, USA</affiliation><affiliation>Department of Psychiatry and Behavioral Sciences, University of Washington, 98195, Seattle, WA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Kluwer Academic Publishers</publisher><place><placeTerm type="text">Boston</placeTerm></place><dateIssued encoding="w3cdtf">2000-05-01</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: A review of the literature reveals an impressively broad spectrum of effects of the hormone estrogen in the CNS. 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