LFG: a candidate apoptosis regulatory gene family
Identifieur interne : 001110 ( Istex/Corpus ); précédent : 001109; suivant : 001111LFG: a candidate apoptosis regulatory gene family
Auteurs : Lan Hu ; Temple F. Smith ; Gabriel GoldbergerSource :
- Apoptosis [ 1360-8185 ] ; 2009-11-01.
English descriptors
Abstract
Abstract: The expanding wealth of human, model and other organism’s genomic data has allowed the identification of a distinct gene family of apoptotic related genes. Most of these genes are currently unannotated or have been subsumed under two questionably related gene families in the past. For example the transmembrane Bax inhibitor 1 (BI1) motif family has been reported to play a role in apoptosis and to consist of at least seven mammalian protein genes, GRINA, BI1, Lfg/FAIM2, Ghitm, RESC1/Tmbim1, GAAP/Tmbim4, and Tmbm1b. However, a detailed sequence and phylogenetic analysis shows that only five of these form a clear and unique protein family. This now provides information for understanding and investigating the biological roles of these proteins across a wide range of tissues in model organisms. The evolutionary relationships among these genes provide a powerful prospective for extrapolating to human conditions.
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DOI: 10.1007/s10495-009-0402-2
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ISTEX:08ED62AB21C0A368CB4309A9942DAE5777E43A33Le document en format XML
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family</ArticleTitle><ArticleCategory>Original paper</ArticleCategory><ArticleFirstPage>1255</ArticleFirstPage><ArticleLastPage>1265</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2009</Year><Month>9</Month><Day>11</Day></RegistrationDate><OnlineDate><Year>2009</Year><Month>9</Month><Day>27</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer Science+Business Media, LLC</CopyrightHolderName><CopyrightYear>2009</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>Lan</GivenName><FamilyName>Hu</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2" CorrespondingAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Temple</GivenName><GivenName>F.</GivenName><FamilyName>Smith</FamilyName></AuthorName><Contact><Phone>+1-617-3537123</Phone><Fax>+1-617-3537020</Fax><Email>tsmith@darwin.bu.edu</Email></Contact></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Gabriel</GivenName><FamilyName>Goldberger</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Graduate Program in Bioinformatics</OrgDivision><OrgName>Boston University</OrgName><OrgAddress><Street>24 Cummington Street</Street><City>Boston</City><State>MA</State><Postcode>02215</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>BioMolecular Engineering Research Center</OrgDivision><OrgName>Boston University</OrgName><OrgAddress><Street>36 Cummington Street</Street><City>Boston</City><State>MA</State><Postcode>02215</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Psychiatry</OrgDivision><OrgName>Beth Israel Deaconess Medical Center</OrgName><OrgAddress><Street>330 Brookline Avenue</Street><City>Boston</City><State>MA</State><Postcode>02215</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>The expanding wealth of human, model and other organism’s genomic data has allowed the identification of a distinct gene family of apoptotic related genes. Most of these genes are currently unannotated or have been subsumed under two questionably related gene families in the past. For example the transmembrane Bax inhibitor 1 (BI1) motif family has been reported to play a role in apoptosis and to consist of at least seven mammalian protein genes, <Emphasis Type="Italic">GRINA</Emphasis>, <Emphasis Type="Italic">BI1</Emphasis>, <Emphasis Type="Italic">Lfg</Emphasis>/<Emphasis Type="Italic">FAIM2</Emphasis>, <Emphasis Type="Italic">Ghitm</Emphasis>, <Emphasis Type="Italic">RESC1</Emphasis>/<Emphasis Type="Italic">Tmbim1</Emphasis>, <Emphasis Type="Italic">GAAP</Emphasis>/<Emphasis Type="Italic">Tmbim4</Emphasis>, and <Emphasis Type="Italic">Tmbm1b</Emphasis>. However, a detailed sequence and phylogenetic analysis shows that only five of these form a clear and unique protein family. This now provides information for understanding and investigating the biological roles of these proteins across a wide range of tissues in model organisms. The evolutionary relationships among these genes provide a powerful prospective for extrapolating to human conditions.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Apoptosis</Keyword><Keyword>Gene duplication</Keyword><Keyword>Evolution</Keyword><Keyword>Phylogenetic analysis</Keyword><Keyword>Consensus pattern</Keyword></KeywordGroup><ArticleNote Type="ESMHint"><Heading>Electronic supplementary material</Heading><SimplePara>The online version of this article (doi:<ExternalRef><RefSource>10.1007/s10495-009-0402-2</RefSource><RefTarget Address="10.1007/s10495-009-0402-2" TargetType="DOI"></RefTarget></ExternalRef>) contains supplementary material, which is available to authorized users.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>LFG: a candidate apoptosis regulatory gene family</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>LFG: a candidate apoptosis regulatory gene family</title></titleInfo><name type="personal"><namePart type="given">Lan</namePart><namePart type="family">Hu</namePart><affiliation>Graduate Program in Bioinformatics, Boston University, 24 Cummington Street, 02215, Boston, MA, USA</affiliation><affiliation>BioMolecular Engineering Research Center, Boston University, 36 Cummington Street, 02215, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Temple</namePart><namePart type="given">F.</namePart><namePart type="family">Smith</namePart><affiliation>BioMolecular Engineering Research Center, Boston University, 36 Cummington Street, 02215, Boston, MA, USA</affiliation><affiliation>E-mail: tsmith@darwin.bu.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gabriel</namePart><namePart type="family">Goldberger</namePart><affiliation>Department of Psychiatry, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer US; http://www.springer-ny.com</publisher><place><placeTerm type="text">Boston</placeTerm></place><dateIssued encoding="w3cdtf">2009-11-01</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: The expanding wealth of human, model and other organism’s genomic data has allowed the identification of a distinct gene family of apoptotic related genes. 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The evolutionary relationships among these genes provide a powerful prospective for extrapolating to human conditions.</abstract><note>Original paper</note><subject lang="en"><genre>Keywords</genre><topic>Apoptosis</topic><topic>Gene duplication</topic><topic>Evolution</topic><topic>Phylogenetic analysis</topic><topic>Consensus pattern</topic></subject><relatedItem type="host"><titleInfo><title>Apoptosis</title><subTitle>An International Journal on Programmed Cell Death</subTitle></titleInfo><titleInfo type="abbreviated"><title>Apoptosis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2009-10-06</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Virology</topic><topic>Biochemistry, general</topic><topic>Oncology</topic><topic>Cell Biology</topic><topic>Cancer Research</topic></subject><identifier type="ISSN">1360-8185</identifier><identifier type="eISSN">1573-675X</identifier><identifier type="JournalID">10495</identifier><identifier type="IssueArticleCount">12</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2009</date><detail type="volume"><number>14</number><caption>vol.</caption></detail><detail type="issue"><number>11</number><caption>no.</caption></detail><extent unit="pages"><start>1255</start><end>1265</end></extent></part><recordInfo><recordOrigin>Springer Science+Business Media, LLC, 2009</recordOrigin></recordInfo></relatedItem><identifier type="istex">08ED62AB21C0A368CB4309A9942DAE5777E43A33</identifier><identifier type="ark">ark:/67375/VQC-677R2LDG-M</identifier><identifier type="DOI">10.1007/s10495-009-0402-2</identifier><identifier type="ArticleID">402</identifier><identifier type="ArticleID">s10495-009-0402-2</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media, LLC, 2009</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Science+Business Media, LLC, 2009</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-677R2LDG-M/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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