Structure and Function of a Long Alternating Purine-Pyrimidine Sequence in the Mouse Alcohol Dehydrogenase Adh-1 Gene
Identifieur interne : 001039 ( Istex/Corpus ); précédent : 001038; suivant : 001040Structure and Function of a Long Alternating Purine-Pyrimidine Sequence in the Mouse Alcohol Dehydrogenase Adh-1 Gene
Auteurs : M. Yu ; H. J. EdenbergSource :
- Archives of Biochemistry and Biophysics [ 0003-9861 ] ; 1995.
Abstract
Abstract: The mouse alcohol dehydrogenase gene Adh-1 contains an unusually long alternating purine-pyrimidine sequence within its first intron. This alternating sequence differs in length between strains that differ in the extent of Adh-1 expression, and it has been suggested that it plays a role in gene expression. We demonstrate that this alternating sequence can form Z-DNA in vitro. The alternating sequence can act as a positive regulatory element in transient transfection assays in hepatoma cell lines, but not in CV-1 (monkey kidney) cells, suggesting that it can act as a tissue-specific regulatory element. Nuclear run-on experiments showed that the differential expression of Adh-1 from high- and low-activity strains is, however, controlled at the post-transcription level.
Url:
DOI: 10.1006/abbi.1995.1054
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Yu</name><affiliation><mods:affiliation>Indiana Univ, Sch Med, Dept Biochem & Molec Biol, Indianapolis, IN 46202, USA</mods:affiliation></affiliation></author><author><name sortKey="Edenberg, H J" sort="Edenberg, H J" uniqKey="Edenberg H" first="H. J." last="Edenberg">H. J. 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This alternating sequence differs in length between strains that differ in the extent of Adh-1 expression, and it has been suggested that it plays a role in gene expression. We demonstrate that this alternating sequence can form Z-DNA in vitro. The alternating sequence can act as a positive regulatory element in transient transfection assays in hepatoma cell lines, but not in CV-1 (monkey kidney) cells, suggesting that it can act as a tissue-specific regulatory element. Nuclear run-on experiments showed that the differential expression of Adh-1 from high- and low-activity strains is, however, controlled at the post-transcription level.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>M. Yu</name><affiliations><json:string>Indiana Univ, Sch Med, Dept Biochem & Molec Biol, Indianapolis, IN 46202, USA</json:string></affiliations></json:item><json:item><name>H.J. 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This alternating sequence differs in length between strains that differ in the extent of <ce:italic>Adh-1</ce:italic> expression, and it has been suggested that it plays a role in gene expression. We demonstrate that this alternating sequence can form Z-DNA <ce:italic>in vitro</ce:italic>. The alternating sequence can act as a positive regulatory element in transient transfection assays in hepatoma cell lines, but not in CV-1 (monkey kidney) cells, suggesting that it can act as a tissue-specific regulatory element. Nuclear run-on experiments showed that the differential expression of <ce:italic>Adh-1</ce:italic> from high- and low-activity strains is, however, controlled at the post-transcription level.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Structure and Function of a Long Alternating Purine-Pyrimidine Sequence in the Mouse Alcohol Dehydrogenase Adh-1 Gene</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Structure and Function of a Long Alternating Purine-Pyrimidine Sequence in the Mouse Alcohol Dehydrogenase</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Yu</namePart><affiliation>Indiana Univ, Sch Med, Dept Biochem & Molec Biol, Indianapolis, IN 46202, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.J.</namePart><namePart type="family">Edenberg</namePart><affiliation>Indiana Univ, Sch Med, Dept Biochem & Molec Biol, Indianapolis, IN 46202, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The mouse alcohol dehydrogenase gene Adh-1 contains an unusually long alternating purine-pyrimidine sequence within its first intron. This alternating sequence differs in length between strains that differ in the extent of Adh-1 expression, and it has been suggested that it plays a role in gene expression. We demonstrate that this alternating sequence can form Z-DNA in vitro. The alternating sequence can act as a positive regulatory element in transient transfection assays in hepatoma cell lines, but not in CV-1 (monkey kidney) cells, suggesting that it can act as a tissue-specific regulatory element. 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