Higher Frequency of HIV-1–Specific T Cell Immune Responses in African American Children Vertically Infected with HIV-1
Identifieur interne : 000A48 ( Istex/Checkpoint ); précédent : 000A47; suivant : 000A49Higher Frequency of HIV-1–Specific T Cell Immune Responses in African American Children Vertically Infected with HIV-1
Auteurs : Elizabeth R. Sharp [États-Unis] ; Jason D. Barbour ; R. Karl Karlsson ; Kimberly A. Jordan ; Johan K. Sandberg ; Andrew Wiznia [États-Unis] ; Michael G. Rosenberg [États-Unis] ; Douglas F. NixonSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2005.
Abstract
The progression of human immunodeficiency virus (HIV) disease and plasma levels of HIV may differ between racial groups. We compared HIV-specific T cell responses between vertically HIV-1–infected Hispanic and African American children. Subjects were matched for sex, age, viral load, and CD4+ cell count in 18 pairs; T cell responses were measured by cytokine-enhanced interferon-γ assay. Peripheral blood mononuclear cells were stimulated with HIV consensus peptides from Gag, Nef, and Tat. The influence of ethnicity, sex, age, viral load, and CD4+ cell count on T cell responses was determined through linear regression analyses. After adjustment for CD4+ count, age, and log10 viral load, African American children demonstrated significantly higher Gag responses (average, 486 spot-forming cells higher; P=.01) than Hispanic children; this was significantly driven by robust responses in African American girls near the age of puberty, many of whom carried the human leukocyte antigen class I B*58 allele
Url:
DOI: 10.1086/462423
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:62ED94B5D1DFCF3A7A4CA67A9C960B71009D830CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Higher Frequency of HIV-1–Specific T Cell Immune Responses in African American Children Vertically Infected with HIV-1</title>
<author><name sortKey="Sharp, Elizabeth R" sort="Sharp, Elizabeth R" uniqKey="Sharp E" first="Elizabeth R." last="Sharp">Elizabeth R. Sharp</name>
</author>
<author><name sortKey="Barbour, Jason D" sort="Barbour, Jason D" uniqKey="Barbour J" first="Jason D." last="Barbour">Jason D. Barbour</name>
</author>
<author><name sortKey="Karlsson, R Karl" sort="Karlsson, R Karl" uniqKey="Karlsson R" first="R. Karl" last="Karlsson">R. Karl Karlsson</name>
</author>
<author><name sortKey="Jordan, Kimberly A" sort="Jordan, Kimberly A" uniqKey="Jordan K" first="Kimberly A." last="Jordan">Kimberly A. Jordan</name>
</author>
<author><name sortKey="Sandberg, Johan K" sort="Sandberg, Johan K" uniqKey="Sandberg J" first="Johan K." last="Sandberg">Johan K. Sandberg</name>
</author>
<author><name sortKey="Wiznia, Andrew" sort="Wiznia, Andrew" uniqKey="Wiznia A" first="Andrew" last="Wiznia">Andrew Wiznia</name>
</author>
<author><name sortKey="Rosenberg, Michael G" sort="Rosenberg, Michael G" uniqKey="Rosenberg M" first="Michael G." last="Rosenberg">Michael G. Rosenberg</name>
</author>
<author><name sortKey="Nixon, Douglas F" sort="Nixon, Douglas F" uniqKey="Nixon D" first="Douglas F." last="Nixon">Douglas F. Nixon</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:62ED94B5D1DFCF3A7A4CA67A9C960B71009D830C</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1086/462423</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-Q8V59NG2-3/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001D32</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D32</idno>
<idno type="wicri:Area/Istex/Curation">001D32</idno>
<idno type="wicri:Area/Istex/Checkpoint">000A48</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000A48</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Higher Frequency of HIV-1–Specific T Cell Immune Responses in African American Children Vertically Infected with HIV-1<ref type="fn" target="#fn1"></ref>
<ref type="fn" target="#fn2"></ref>
</title>
<author><name sortKey="Sharp, Elizabeth R" sort="Sharp, Elizabeth R" uniqKey="Sharp E" first="Elizabeth R." last="Sharp">Elizabeth R. Sharp</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Barbour, Jason D" sort="Barbour, Jason D" uniqKey="Barbour J" first="Jason D." last="Barbour">Jason D. Barbour</name>
<affiliation></affiliation>
<affiliation><wicri:noCountry code="subField">Francisco;</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Karlsson, R Karl" sort="Karlsson, R Karl" uniqKey="Karlsson R" first="R. Karl" last="Karlsson">R. Karl Karlsson</name>
<affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jordan, Kimberly A" sort="Jordan, Kimberly A" uniqKey="Jordan K" first="Kimberly A." last="Jordan">Kimberly A. Jordan</name>
<affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sandberg, Johan K" sort="Sandberg, Johan K" uniqKey="Sandberg J" first="Johan K." last="Sandberg">Johan K. Sandberg</name>
<affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wiznia, Andrew" sort="Wiznia, Andrew" uniqKey="Wiznia A" first="Andrew" last="Wiznia">Andrew Wiznia</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Jacobi Medical Center, Albert Einstein College of Medicine, Bronx</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rosenberg, Michael G" sort="Rosenberg, Michael G" uniqKey="Rosenberg M" first="Michael G." last="Rosenberg">Michael G. Rosenberg</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Jacobi Medical Center, Albert Einstein College of Medicine, Bronx</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nixon, Douglas F" sort="Nixon, Douglas F" uniqKey="Nixon D" first="Douglas F." last="Nixon">Douglas F. Nixon</name>
<affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The Journal of Infectious Diseases</title>
<title level="j" type="abbrev">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date type="published">2005</date>
<biblScope unit="vol">192</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="1772">1772</biblScope>
<biblScope unit="page" to="1780">1780</biblScope>
</imprint>
<idno type="ISSN">0022-1899</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">The progression of human immunodeficiency virus (HIV) disease and plasma levels of HIV may differ between racial groups. We compared HIV-specific T cell responses between vertically HIV-1–infected Hispanic and African American children. Subjects were matched for sex, age, viral load, and CD4+ cell count in 18 pairs; T cell responses were measured by cytokine-enhanced interferon-γ assay. Peripheral blood mononuclear cells were stimulated with HIV consensus peptides from Gag, Nef, and Tat. The influence of ethnicity, sex, age, viral load, and CD4+ cell count on T cell responses was determined through linear regression analyses. After adjustment for CD4+ count, age, and log10 viral load, African American children demonstrated significantly higher Gag responses (average, 486 spot-forming cells higher; P=.01) than Hispanic children; this was significantly driven by robust responses in African American girls near the age of puberty, many of whom carried the human leukocyte antigen class I B*58 allele</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><noCountry><name sortKey="Barbour, Jason D" sort="Barbour, Jason D" uniqKey="Barbour J" first="Jason D." last="Barbour">Jason D. Barbour</name>
<name sortKey="Jordan, Kimberly A" sort="Jordan, Kimberly A" uniqKey="Jordan K" first="Kimberly A." last="Jordan">Kimberly A. Jordan</name>
<name sortKey="Karlsson, R Karl" sort="Karlsson, R Karl" uniqKey="Karlsson R" first="R. Karl" last="Karlsson">R. Karl Karlsson</name>
<name sortKey="Nixon, Douglas F" sort="Nixon, Douglas F" uniqKey="Nixon D" first="Douglas F." last="Nixon">Douglas F. Nixon</name>
<name sortKey="Sandberg, Johan K" sort="Sandberg, Johan K" uniqKey="Sandberg J" first="Johan K." last="Sandberg">Johan K. Sandberg</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Sharp, Elizabeth R" sort="Sharp, Elizabeth R" uniqKey="Sharp E" first="Elizabeth R." last="Sharp">Elizabeth R. Sharp</name>
</noRegion>
<name sortKey="Rosenberg, Michael G" sort="Rosenberg, Michael G" uniqKey="Rosenberg M" first="Michael G." last="Rosenberg">Michael G. Rosenberg</name>
<name sortKey="Wiznia, Andrew" sort="Wiznia, Andrew" uniqKey="Wiznia A" first="Andrew" last="Wiznia">Andrew Wiznia</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A48 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 000A48 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Istex |étape= Checkpoint |type= RBID |clé= ISTEX:62ED94B5D1DFCF3A7A4CA67A9C960B71009D830C |texte= Higher Frequency of HIV-1–Specific T Cell Immune Responses in African American Children Vertically Infected with HIV-1 }}
This area was generated with Dilib version V0.6.33. |