Higher Frequency of HIV-1–Specific T Cell Immune Responses in African American Children Vertically Infected with HIV-1
Identifieur interne : 001D32 ( Istex/Curation ); précédent : 001D31; suivant : 001D33Higher Frequency of HIV-1–Specific T Cell Immune Responses in African American Children Vertically Infected with HIV-1
Auteurs : Elizabeth R. Sharp [États-Unis] ; Jason D. Barbour ; R. Karl Karlsson ; Kimberly A. Jordan ; Johan K. Sandberg ; Andrew Wiznia [États-Unis] ; Michael G. Rosenberg [États-Unis] ; Douglas F. NixonSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2005.
Abstract
The progression of human immunodeficiency virus (HIV) disease and plasma levels of HIV may differ between racial groups. We compared HIV-specific T cell responses between vertically HIV-1–infected Hispanic and African American children. Subjects were matched for sex, age, viral load, and CD4+ cell count in 18 pairs; T cell responses were measured by cytokine-enhanced interferon-γ assay. Peripheral blood mononuclear cells were stimulated with HIV consensus peptides from Gag, Nef, and Tat. The influence of ethnicity, sex, age, viral load, and CD4+ cell count on T cell responses was determined through linear regression analyses. After adjustment for CD4+ count, age, and log10 viral load, African American children demonstrated significantly higher Gag responses (average, 486 spot-forming cells higher; P=.01) than Hispanic children; this was significantly driven by robust responses in African American girls near the age of puberty, many of whom carried the human leukocyte antigen class I B*58 allele
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DOI: 10.1086/462423
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Jason D. Barbour<affiliation><mods:affiliation>Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco;</mods:affiliation><wicri:noCountry code="subField">Francisco;</wicri:noCountry></affiliation><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry></affiliation>Le document en format XML
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Sharp</name><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: esharp@itsa.ucsf.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Barbour, Jason D" sort="Barbour, Jason D" uniqKey="Barbour J" first="Jason D." last="Barbour">Jason D. Barbour</name><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation></affiliation><affiliation><mods:affiliation>Positive Health Program, San Francisco General Hospital, University of California, San Francisco, San Francisco;</mods:affiliation><wicri:noCountry code="subField">Francisco;</wicri:noCountry></affiliation></author><author><name sortKey="Karlsson, R Karl" sort="Karlsson, R Karl" uniqKey="Karlsson R" first="R. Karl" last="Karlsson">R. Karl Karlsson</name><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry></affiliation></author><author><name sortKey="Jordan, Kimberly A" sort="Jordan, Kimberly A" uniqKey="Jordan K" first="Kimberly A." last="Jordan">Kimberly A. Jordan</name><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry></affiliation></author><author><name sortKey="Sandberg, Johan K" sort="Sandberg, Johan K" uniqKey="Sandberg J" first="Johan K." last="Sandberg">Johan K. 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Rosenberg</name><affiliation wicri:level="2"><mods:affiliation>Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Jacobi Medical Center, Albert Einstein College of Medicine, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Nixon, Douglas F" sort="Nixon, Douglas F" uniqKey="Nixon D" first="Douglas F." last="Nixon">Douglas F. Nixon</name><affiliation><mods:affiliation>Gladstone Institute of Virology and Immunology and</mods:affiliation><wicri:noCountry code="no comma">Gladstone Institute of Virology and Immunology and</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2005</date><biblScope unit="vol">192</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1772">1772</biblScope><biblScope unit="page" to="1780">1780</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The progression of human immunodeficiency virus (HIV) disease and plasma levels of HIV may differ between racial groups. We compared HIV-specific T cell responses between vertically HIV-1–infected Hispanic and African American children. Subjects were matched for sex, age, viral load, and CD4+ cell count in 18 pairs; T cell responses were measured by cytokine-enhanced interferon-γ assay. Peripheral blood mononuclear cells were stimulated with HIV consensus peptides from Gag, Nef, and Tat. The influence of ethnicity, sex, age, viral load, and CD4+ cell count on T cell responses was determined through linear regression analyses. After adjustment for CD4+ count, age, and log10 viral load, African American children demonstrated significantly higher Gag responses (average, 486 spot-forming cells higher; P=.01) than Hispanic children; this was significantly driven by robust responses in African American girls near the age of puberty, many of whom carried the human leukocyte antigen class I B*58 allele</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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