Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.
Identifieur interne : 00B531 ( Ncbi/Curation ); précédent : 00B530; suivant : 00B532Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.
Auteurs : N M Mckechnie [Royaume-Uni] ; G. Braun ; V. Connor ; S. Kl Ger ; D W Taylor ; R A Alexander ; C E GilbertSource :
- Investigative ophthalmology & visual science [ 0146-0404 ] ; 1993.
Descripteurs français
- KwdFr :
- ADN des protozoaires, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (immunologie), Antigènes d'helminthe (immunologie), Autoanticorps (immunologie), Femelle, Filariose lymphatique (immunologie), Humains, Hybridation d'acides nucléiques, Lapins, Mâle, Onchocercose oculaire (anatomopathologie), Onchocercose oculaire (immunologie), Réactions croisées (immunologie), Technique de Western, Techniques immunoenzymatiques, Électrophorèse sur gel de polyacrylamide.
- MESH :
- anatomopathologie : Onchocercose oculaire.
- immunologie : Anticorps antihelminthe, Antigènes d'helminthe, Autoanticorps, Filariose lymphatique, Onchocercose oculaire, Réactions croisées.
- ADN des protozoaires, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Hybridation d'acides nucléiques, Lapins, Mâle, Technique de Western, Techniques immunoenzymatiques, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Helminth (immunology), Antigens, Helminth (immunology), Autoantibodies (immunology), Blotting, Western, Cross Reactions (immunology), DNA, Protozoan, Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (immunology), Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Nucleic Acid Hybridization, Onchocerciasis, Ocular (immunology), Onchocerciasis, Ocular (pathology), Rabbits.
- MESH :
- chemical , immunology : Antibodies, Helminth, Antigens, Helminth, Autoantibodies.
- immunology : Cross Reactions, Elephantiasis, Filarial, Onchocerciasis, Ocular.
- pathology : Onchocerciasis, Ocular.
- Adult, Animals, Blotting, Western, DNA, Protozoan, Electrophoresis, Polyacrylamide Gel, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Nucleic Acid Hybridization, Rabbits.
Abstract
Onchocerca volvulus, a filarial worm, is a major cause of infectious blindness and inflammatory eye disease. An autoimmune cause for ocular onchocerciasis has been suggested since the identification of a recombinant antigen of O. volvulus that shows immunologic cross-reactivity with a host ocular component of 44,000 M(r). The aim of this study was to establish the distribution of the cross-reactive antigens in both host tissues and the parasite, and to determine if significant autoantibody responses to the host antigen could be detected in infected persons.
PubMed: 8360022
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pubmed:8360022Le document en format XML
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Braun</name></author><author><name sortKey="Connor, V" sort="Connor, V" uniqKey="Connor V" first="V" last="Connor">V. Connor</name></author><author><name sortKey="Kl Ger, S" sort="Kl Ger, S" uniqKey="Kl Ger S" first="S" last="Kl Ger">S. Kl Ger</name></author><author><name sortKey="Taylor, D W" sort="Taylor, D W" uniqKey="Taylor D" first="D W" last="Taylor">D W Taylor</name></author><author><name sortKey="Alexander, R A" sort="Alexander, R A" uniqKey="Alexander R" first="R A" last="Alexander">R A Alexander</name></author><author><name sortKey="Gilbert, C E" sort="Gilbert, C E" uniqKey="Gilbert C" first="C E" last="Gilbert">C E Gilbert</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8360022</idno><idno type="pmid">8360022</idno><idno type="wicri:Area/PubMed/Corpus">005687</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005687</idno><idno type="wicri:Area/PubMed/Curation">005687</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005687</idno><idno type="wicri:Area/PubMed/Checkpoint">005687</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005687</idno><idno type="wicri:Area/Ncbi/Merge">00B531</idno><idno type="wicri:Area/Ncbi/Curation">00B531</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.</title><author><name sortKey="Mckechnie, N M" sort="Mckechnie, N M" uniqKey="Mckechnie N" first="N M" last="Mckechnie">N M Mckechnie</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Braun, G" sort="Braun, G" uniqKey="Braun G" first="G" last="Braun">G. Braun</name></author><author><name sortKey="Connor, V" sort="Connor, V" uniqKey="Connor V" first="V" last="Connor">V. Connor</name></author><author><name sortKey="Kl Ger, S" sort="Kl Ger, S" uniqKey="Kl Ger S" first="S" last="Kl Ger">S. Kl Ger</name></author><author><name sortKey="Taylor, D W" sort="Taylor, D W" uniqKey="Taylor D" first="D W" last="Taylor">D W Taylor</name></author><author><name sortKey="Alexander, R A" sort="Alexander, R A" uniqKey="Alexander R" first="R A" last="Alexander">R A Alexander</name></author><author><name sortKey="Gilbert, C E" sort="Gilbert, C E" uniqKey="Gilbert C" first="C E" last="Gilbert">C E Gilbert</name></author></analytic><series><title level="j">Investigative ophthalmology & visual science</title><idno type="ISSN">0146-0404</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Antibodies, Helminth (immunology)</term><term>Antigens, Helminth (immunology)</term><term>Autoantibodies (immunology)</term><term>Blotting, Western</term><term>Cross Reactions (immunology)</term><term>DNA, Protozoan</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Middle Aged</term><term>Nucleic Acid Hybridization</term><term>Onchocerciasis, Ocular (immunology)</term><term>Onchocerciasis, Ocular (pathology)</term><term>Rabbits</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN des protozoaires</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (immunologie)</term><term>Antigènes d'helminthe (immunologie)</term><term>Autoanticorps (immunologie)</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Hybridation d'acides nucléiques</term><term>Lapins</term><term>Mâle</term><term>Onchocercose oculaire (anatomopathologie)</term><term>Onchocercose oculaire (immunologie)</term><term>Réactions croisées (immunologie)</term><term>Technique de Western</term><term>Techniques immunoenzymatiques</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term><term>Autoantibodies</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Onchocercose oculaire</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes d'helminthe</term><term>Autoanticorps</term><term>Filariose lymphatique</term><term>Onchocercose oculaire</term><term>Réactions croisées</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term><term>Elephantiasis, Filarial</term><term>Onchocerciasis, Ocular</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Onchocerciasis, Ocular</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Blotting, Western</term><term>DNA, Protozoan</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Middle Aged</term><term>Nucleic Acid Hybridization</term><term>Rabbits</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN des protozoaires</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Hybridation d'acides nucléiques</term><term>Lapins</term><term>Mâle</term><term>Technique de Western</term><term>Techniques immunoenzymatiques</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Onchocerca volvulus, a filarial worm, is a major cause of infectious blindness and inflammatory eye disease. An autoimmune cause for ocular onchocerciasis has been suggested since the identification of a recombinant antigen of O. volvulus that shows immunologic cross-reactivity with a host ocular component of 44,000 M(r). The aim of this study was to establish the distribution of the cross-reactive antigens in both host tissues and the parasite, and to determine if significant autoantibody responses to the host antigen could be detected in infected persons.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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