Safety and efficacy of human growth hormone treatment in girls with Turner syndrome.
Identifieur interne : 00B530 ( Ncbi/Curation ); précédent : 00B529; suivant : 00B531Safety and efficacy of human growth hormone treatment in girls with Turner syndrome.
Auteurs : D A Price [Royaume-Uni] ; P E Clayton ; E H Crowne ; C R RobertsSource :
- Hormone research [ 0301-0163 ] ; 1993.
Descripteurs français
- KwdFr :
- Adolescent, Analyse de régression, Comportement (), Crises épileptiques (), Croissance (), Encoprésie (), Encoprésie (psychologie), Enfant, Femelle, Glycémie (analyse), Hormone de croissance (effets indésirables), Hormone de croissance (usage thérapeutique), Humains, Hémoglobine A glycosylée (analyse), Lymphoedème (), Pression sanguine (), Protéines recombinantes (effets indésirables), Protéines recombinantes (usage thérapeutique), Relation dose-effet des médicaments, Syndrome de Turner (psychologie), Syndrome de Turner (traitement médicamenteux), Taille (), Triglycéride (sang), Troubles des tics (), Énurésie (), Énurésie (psychologie).
- MESH :
- analyse : Glycémie, Hémoglobine A glycosylée.
- effets indésirables : Hormone de croissance, Protéines recombinantes.
- psychologie : Encoprésie, Syndrome de Turner, Énurésie.
- sang : Triglycéride.
- traitement médicamenteux : Syndrome de Turner.
- usage thérapeutique : Hormone de croissance, Protéines recombinantes.
- Adolescent, Analyse de régression, Comportement, Crises épileptiques, Croissance, Encoprésie, Enfant, Femelle, Humains, Lymphoedème, Pression sanguine, Relation dose-effet des médicaments, Taille, Troubles des tics, Énurésie.
English descriptors
- KwdEn :
- Adolescent, Behavior (drug effects), Blood Glucose (analysis), Blood Pressure (drug effects), Body Height (drug effects), Child, Dose-Response Relationship, Drug, Encopresis (chemically induced), Encopresis (psychology), Enuresis (chemically induced), Enuresis (psychology), Female, Growth (drug effects), Growth Hormone (adverse effects), Growth Hormone (therapeutic use), Hemoglobin A, Glycosylated (analysis), Humans, Lymphedema (chemically induced), Recombinant Proteins (adverse effects), Recombinant Proteins (therapeutic use), Regression Analysis, Seizures (chemically induced), Tic Disorders (chemically induced), Triglycerides (blood), Turner Syndrome (drug therapy), Turner Syndrome (psychology).
- MESH :
- chemical , adverse effects : Growth Hormone, Recombinant Proteins.
- chemical , analysis : Blood Glucose, Hemoglobin A, Glycosylated.
- chemical , blood : Triglycerides.
- chemically induced : Encopresis, Enuresis, Lymphedema, Seizures, Tic Disorders.
- drug effects : Behavior, Blood Pressure, Body Height, Growth.
- drug therapy : Turner Syndrome.
- psychology : Encopresis, Enuresis, Turner Syndrome.
- chemical , therapeutic use : Growth Hormone, Recombinant Proteins.
- Adolescent, Child, Dose-Response Relationship, Drug, Female, Humans, Regression Analysis.
Abstract
Six major adverse medical events (AMEs) and 44 minor AMEs were recorded in 6 and 23 patients, respectively, during human growth hormone (GH) treatment of Turner syndrome, equivalent to 118 treatment years. During the first year of GH treatment, there was no change in the SD score (SDS) for systolic or diastolic blood pressure. In a subgroup of 20 patients, there was no change in psychological tests, oral glucose tolerance, glycosylated haemoglobin or serum triglycerides over the first year of GH treatment. The mean total serum cholesterol level fell over this period. The low incidence of adverse medical problems during GH treatment complemented its efficacy. Height velocity in the first year was 7.7 +/- 1.8 cm/year (mean +/- SD) and was correlated with maternal height SDS, though not with paternal height SDS. Some 36% of first-year height velocity SDS could be predicted by the dose of GH and maternal height SDS.
PubMed: 8359788
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pubmed:8359788Le document en format XML
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Crowne, E H" sort="Crowne, E H" uniqKey="Crowne E" first="E H" last="Crowne">E H Crowne</name>
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<term>Behavior (drug effects)</term>
<term>Blood Glucose (analysis)</term>
<term>Blood Pressure (drug effects)</term>
<term>Body Height (drug effects)</term>
<term>Child</term>
<term>Dose-Response Relationship, Drug</term>
<term>Encopresis (chemically induced)</term>
<term>Encopresis (psychology)</term>
<term>Enuresis (chemically induced)</term>
<term>Enuresis (psychology)</term>
<term>Female</term>
<term>Growth (drug effects)</term>
<term>Growth Hormone (adverse effects)</term>
<term>Growth Hormone (therapeutic use)</term>
<term>Hemoglobin A, Glycosylated (analysis)</term>
<term>Humans</term>
<term>Lymphedema (chemically induced)</term>
<term>Recombinant Proteins (adverse effects)</term>
<term>Recombinant Proteins (therapeutic use)</term>
<term>Regression Analysis</term>
<term>Seizures (chemically induced)</term>
<term>Tic Disorders (chemically induced)</term>
<term>Triglycerides (blood)</term>
<term>Turner Syndrome (drug therapy)</term>
<term>Turner Syndrome (psychology)</term>
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<term>Analyse de régression</term>
<term>Comportement ()</term>
<term>Crises épileptiques ()</term>
<term>Croissance ()</term>
<term>Encoprésie ()</term>
<term>Encoprésie (psychologie)</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Glycémie (analyse)</term>
<term>Hormone de croissance (effets indésirables)</term>
<term>Hormone de croissance (usage thérapeutique)</term>
<term>Humains</term>
<term>Hémoglobine A glycosylée (analyse)</term>
<term>Lymphoedème ()</term>
<term>Pression sanguine ()</term>
<term>Protéines recombinantes (effets indésirables)</term>
<term>Protéines recombinantes (usage thérapeutique)</term>
<term>Relation dose-effet des médicaments</term>
<term>Syndrome de Turner (psychologie)</term>
<term>Syndrome de Turner (traitement médicamenteux)</term>
<term>Taille ()</term>
<term>Triglycéride (sang)</term>
<term>Troubles des tics ()</term>
<term>Énurésie ()</term>
<term>Énurésie (psychologie)</term>
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<term>Hémoglobine A glycosylée</term>
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<term>Enuresis</term>
<term>Lymphedema</term>
<term>Seizures</term>
<term>Tic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior</term>
<term>Blood Pressure</term>
<term>Body Height</term>
<term>Growth</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Turner Syndrome</term>
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<term>Protéines recombinantes</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Encoprésie</term>
<term>Syndrome de Turner</term>
<term>Énurésie</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Encopresis</term>
<term>Enuresis</term>
<term>Turner Syndrome</term>
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<term>Recombinant Proteins</term>
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<term>Protéines recombinantes</term>
</keywords>
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<term>Child</term>
<term>Dose-Response Relationship, Drug</term>
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<term>Humans</term>
<term>Regression Analysis</term>
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<term>Analyse de régression</term>
<term>Comportement</term>
<term>Crises épileptiques</term>
<term>Croissance</term>
<term>Encoprésie</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphoedème</term>
<term>Pression sanguine</term>
<term>Relation dose-effet des médicaments</term>
<term>Taille</term>
<term>Troubles des tics</term>
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<front><div type="abstract" xml:lang="en">Six major adverse medical events (AMEs) and 44 minor AMEs were recorded in 6 and 23 patients, respectively, during human growth hormone (GH) treatment of Turner syndrome, equivalent to 118 treatment years. During the first year of GH treatment, there was no change in the SD score (SDS) for systolic or diastolic blood pressure. In a subgroup of 20 patients, there was no change in psychological tests, oral glucose tolerance, glycosylated haemoglobin or serum triglycerides over the first year of GH treatment. The mean total serum cholesterol level fell over this period. The low incidence of adverse medical problems during GH treatment complemented its efficacy. Height velocity in the first year was 7.7 +/- 1.8 cm/year (mean +/- SD) and was correlated with maternal height SDS, though not with paternal height SDS. Some 36% of first-year height velocity SDS could be predicted by the dose of GH and maternal height SDS.</div>
</front>
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