Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.
Identifieur interne : 005687 ( PubMed/Corpus ); précédent : 005686; suivant : 005688Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.
Auteurs : N M Mckechnie ; G. Braun ; V. Connor ; S. Kl Ger ; D W Taylor ; R A Alexander ; C E GilbertSource :
- Investigative ophthalmology & visual science [ 0146-0404 ] ; 1993.
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Helminth (immunology), Antigens, Helminth (immunology), Autoantibodies (immunology), Blotting, Western, Cross Reactions (immunology), DNA, Protozoan, Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (immunology), Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Nucleic Acid Hybridization, Onchocerciasis, Ocular (immunology), Onchocerciasis, Ocular (pathology), Rabbits.
- MESH :
- chemical , immunology : Antibodies, Helminth, Antigens, Helminth, Autoantibodies.
- immunology : Cross Reactions, Elephantiasis, Filarial, Onchocerciasis, Ocular.
- pathology : Onchocerciasis, Ocular.
- Adult, Animals, Blotting, Western, DNA, Protozoan, Electrophoresis, Polyacrylamide Gel, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Nucleic Acid Hybridization, Rabbits.
Abstract
Onchocerca volvulus, a filarial worm, is a major cause of infectious blindness and inflammatory eye disease. An autoimmune cause for ocular onchocerciasis has been suggested since the identification of a recombinant antigen of O. volvulus that shows immunologic cross-reactivity with a host ocular component of 44,000 M(r). The aim of this study was to establish the distribution of the cross-reactive antigens in both host tissues and the parasite, and to determine if significant autoantibody responses to the host antigen could be detected in infected persons.
PubMed: 8360022
Links to Exploration step
pubmed:8360022Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.</title><author><name sortKey="Mckechnie, N M" sort="Mckechnie, N M" uniqKey="Mckechnie N" first="N M" last="Mckechnie">N M Mckechnie</name><affiliation><nlm:affiliation>Department of Pathology, University of Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Braun, G" sort="Braun, G" uniqKey="Braun G" first="G" last="Braun">G. Braun</name></author><author><name sortKey="Connor, V" sort="Connor, V" uniqKey="Connor V" first="V" last="Connor">V. Connor</name></author><author><name sortKey="Kl Ger, S" sort="Kl Ger, S" uniqKey="Kl Ger S" first="S" last="Kl Ger">S. Kl Ger</name></author><author><name sortKey="Taylor, D W" sort="Taylor, D W" uniqKey="Taylor D" first="D W" last="Taylor">D W Taylor</name></author><author><name sortKey="Alexander, R A" sort="Alexander, R A" uniqKey="Alexander R" first="R A" last="Alexander">R A Alexander</name></author><author><name sortKey="Gilbert, C E" sort="Gilbert, C E" uniqKey="Gilbert C" first="C E" last="Gilbert">C E Gilbert</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8360022</idno><idno type="pmid">8360022</idno><idno type="wicri:Area/PubMed/Corpus">005687</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005687</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.</title><author><name sortKey="Mckechnie, N M" sort="Mckechnie, N M" uniqKey="Mckechnie N" first="N M" last="Mckechnie">N M Mckechnie</name><affiliation><nlm:affiliation>Department of Pathology, University of Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Braun, G" sort="Braun, G" uniqKey="Braun G" first="G" last="Braun">G. Braun</name></author><author><name sortKey="Connor, V" sort="Connor, V" uniqKey="Connor V" first="V" last="Connor">V. Connor</name></author><author><name sortKey="Kl Ger, S" sort="Kl Ger, S" uniqKey="Kl Ger S" first="S" last="Kl Ger">S. Kl Ger</name></author><author><name sortKey="Taylor, D W" sort="Taylor, D W" uniqKey="Taylor D" first="D W" last="Taylor">D W Taylor</name></author><author><name sortKey="Alexander, R A" sort="Alexander, R A" uniqKey="Alexander R" first="R A" last="Alexander">R A Alexander</name></author><author><name sortKey="Gilbert, C E" sort="Gilbert, C E" uniqKey="Gilbert C" first="C E" last="Gilbert">C E Gilbert</name></author></analytic><series><title level="j">Investigative ophthalmology & visual science</title><idno type="ISSN">0146-0404</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Antibodies, Helminth (immunology)</term><term>Antigens, Helminth (immunology)</term><term>Autoantibodies (immunology)</term><term>Blotting, Western</term><term>Cross Reactions (immunology)</term><term>DNA, Protozoan</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Middle Aged</term><term>Nucleic Acid Hybridization</term><term>Onchocerciasis, Ocular (immunology)</term><term>Onchocerciasis, Ocular (pathology)</term><term>Rabbits</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term><term>Autoantibodies</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term><term>Elephantiasis, Filarial</term><term>Onchocerciasis, Ocular</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Onchocerciasis, Ocular</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Blotting, Western</term><term>DNA, Protozoan</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Middle Aged</term><term>Nucleic Acid Hybridization</term><term>Rabbits</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Onchocerca volvulus, a filarial worm, is a major cause of infectious blindness and inflammatory eye disease. An autoimmune cause for ocular onchocerciasis has been suggested since the identification of a recombinant antigen of O. volvulus that shows immunologic cross-reactivity with a host ocular component of 44,000 M(r). The aim of this study was to establish the distribution of the cross-reactive antigens in both host tissues and the parasite, and to determine if significant autoantibody responses to the host antigen could be detected in infected persons.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8360022</PMID><DateCreated><Year>1993</Year><Month>09</Month><Day>30</Day></DateCreated><DateCompleted><Year>1993</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2010</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0146-0404</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>10</Issue><PubDate><Year>1993</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Investigative ophthalmology & visual science</Title><ISOAbbreviation>Invest. Ophthalmol. Vis. Sci.</ISOAbbreviation></Journal><ArticleTitle>Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.</ArticleTitle><Pagination><MedlinePgn>2888-902</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Onchocerca volvulus, a filarial worm, is a major cause of infectious blindness and inflammatory eye disease. An autoimmune cause for ocular onchocerciasis has been suggested since the identification of a recombinant antigen of O. volvulus that shows immunologic cross-reactivity with a host ocular component of 44,000 M(r). The aim of this study was to establish the distribution of the cross-reactive antigens in both host tissues and the parasite, and to determine if significant autoantibody responses to the host antigen could be detected in infected persons.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The tissue and organ distribution of the 44,000 M(r) antigen was determined by immunocytochemistry and Western blot analysis. Human autoantibody responses to the ocular antigen were demonstrated by Western blot analysis using sera collected from persons with onchocerciasis, with and without posterior segment pathology, Bancroftian filariasis, and Europeans with no filarial infection.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The tissue distribution of the 44,000 M(r) antigen correlates with the sites of pathology in onchocerciasis and antibody reactivity against this antigen could be detected in all persons with onchocerciasis and posterior segment pathology. The antigen is also recognized by sera from persons with Bancroftian filariasis, but not from normal persons.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A role is proposed for immunologic cross-reactivity in the pathogenesis of onchocerciasis and it is suggested that intraocular presentation of the cross-reactive parasite antigen by microfilariae is essential for the development of disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McKechnie</LastName><ForeName>N M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Braun</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Connor</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Kläger</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>D W</ForeName><Initials>DW</Initials></Author><Author ValidYN="Y"><LastName>Alexander</LastName><ForeName>R A</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Gilbert</LastName><ForeName>C E</ForeName><Initials>CE</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Invest Ophthalmol Vis Sci</MedlineTA><NlmUniqueID>7703701</NlmUniqueID><ISSNLinking>0146-0404</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001323">Autoantibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016054">DNA, Protozoan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001323" MajorTopicYN="N">Autoantibodies</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016054" MajorTopicYN="N">DNA, Protozoan</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004591" MajorTopicYN="N">Electrophoresis, Polyacrylamide Gel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007124" MajorTopicYN="N">Immunoenzyme Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009693" MajorTopicYN="N">Nucleic Acid Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015827" MajorTopicYN="N">Onchocerciasis, Ocular</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8360022</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005687 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 005687 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:8360022
|texte= Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:8360022" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |