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The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

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The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

Auteurs : Heng Huang [République populaire de Chine] ; Ting Jin [République populaire de Chine] ; Lin Wang [République populaire de Chine] ; Fulong Wang [République populaire de Chine] ; Rui Zhang [République populaire de Chine] ; Yi Pan [République populaire de Chine] ; Zhenzhen Wang [République populaire de Chine] ; Yan Chen [République populaire de Chine]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.

RBID : PMC:3554906

Abstract

Background: RasGRP1 is a protein involved in Ras activation, but its physiological function is largely unknown.

Results: Knockdown of RasGRP1 impairs development of the lymphatic system in zebrafish embryos, shown as defective thoracic duct formation, pericardial and truck edema, and altered sprouts of lymphatic vessels.

Conclusion: RasGRP1 is involved in lymphangiogenesis in zebrafish.

Significance: RasGRP1 has a physiological function in early development.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554906

DOI: 10.1074/jbc.M112.418202
PubMed: 23184941
PubMed Central: 3554906

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<author><name sortKey="Zhang, Rui" sort="Zhang, Rui" uniqKey="Zhang R" first="Rui" last="Zhang">Rui Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Pan, Yi" sort="Pan, Yi" uniqKey="Pan Y" first="Yi" last="Pan">Yi Pan</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Wang, Zhenzhen" sort="Wang, Zhenzhen" uniqKey="Wang Z" first="Zhenzhen" last="Wang">Zhenzhen Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
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<series><title level="j">The Journal of Biological Chemistry</title>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 RasGRP1 is a protein involved in Ras activation, but its physiological function is largely unknown.</p>
<p><bold>Results:</bold>
 Knockdown of RasGRP1 impairs development of the lymphatic system in zebrafish embryos, shown as defective thoracic duct formation, pericardial and truck edema, and altered sprouts of lymphatic vessels.</p>
<p><bold>Conclusion:</bold>
 RasGRP1 is involved in lymphangiogenesis in zebrafish.</p>
<p><bold>Significance:</bold>
 RasGRP1 has a physiological function in early development.</p>
</div>
</front>
</TEI>
</record>

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The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

Source :

Abstract

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