LymphedemaV1, Pmc, Curation, bibRecord, 002E90

The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

Identifieur interne : 002E90 ( Pmc/Curation ); précédent : 002E89; suivant : 002E91

The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

Auteurs : Heng Huang [République populaire de Chine] ; Ting Jin [République populaire de Chine] ; Lin Wang [République populaire de Chine] ; Fulong Wang [République populaire de Chine] ; Rui Zhang [République populaire de Chine] ; Yi Pan [République populaire de Chine] ; Zhenzhen Wang [République populaire de Chine] ; Yan Chen [République populaire de Chine]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.

RBID : PMC:3554906

Abstract

Background: RasGRP1 is a protein involved in Ras activation, but its physiological function is largely unknown.

Results: Knockdown of RasGRP1 impairs development of the lymphatic system in zebrafish embryos, shown as defective thoracic duct formation, pericardial and truck edema, and altered sprouts of lymphatic vessels.

Conclusion: RasGRP1 is involved in lymphangiogenesis in zebrafish.

Significance: RasGRP1 has a physiological function in early development.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554906

DOI: 10.1074/jbc.M112.418202
PubMed: 23184941
PubMed Central: 3554906

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002E91

Links to Exploration step

PMC:3554906

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish<xref ref-type="fn" rid="FN1">*</xref>
<xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic>
</sup>
</xref>
</title>
<author><name sortKey="Huang, Heng" sort="Huang, Heng" uniqKey="Huang H" first="Heng" last="Huang">Heng Huang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jin, Ting" sort="Jin, Ting" uniqKey="Jin T" first="Ting" last="Jin">Ting Jin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Fulong" sort="Wang, Fulong" uniqKey="Wang F" first="Fulong" last="Wang">Fulong Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Rui" sort="Zhang, Rui" uniqKey="Zhang R" first="Rui" last="Zhang">Rui Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pan, Yi" sort="Pan, Yi" uniqKey="Pan Y" first="Yi" last="Pan">Yi Pan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Zhenzhen" sort="Wang, Zhenzhen" uniqKey="Wang Z" first="Zhenzhen" last="Wang">Zhenzhen Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23184941</idno>
<idno type="pmc">3554906</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554906</idno>
<idno type="RBID">PMC:3554906</idno>
<idno type="doi">10.1074/jbc.M112.418202</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">002E91</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E91</idno>
<idno type="wicri:Area/Pmc/Curation">002E90</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002E90</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish<xref ref-type="fn" rid="FN1">*</xref>
<xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic>
</sup>
</xref>
</title>
<author><name sortKey="Huang, Heng" sort="Huang, Heng" uniqKey="Huang H" first="Heng" last="Huang">Heng Huang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jin, Ting" sort="Jin, Ting" uniqKey="Jin T" first="Ting" last="Jin">Ting Jin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Fulong" sort="Wang, Fulong" uniqKey="Wang F" first="Fulong" last="Wang">Fulong Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Rui" sort="Zhang, Rui" uniqKey="Zhang R" first="Rui" last="Zhang">Rui Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pan, Yi" sort="Pan, Yi" uniqKey="Pan Y" first="Yi" last="Pan">Yi Pan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Zhenzhen" sort="Wang, Zhenzhen" uniqKey="Wang Z" first="Zhenzhen" last="Wang">Zhenzhen Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 RasGRP1 is a protein involved in Ras activation, but its physiological function is largely unknown.</p>
<p><bold>Results:</bold>
 Knockdown of RasGRP1 impairs development of the lymphatic system in zebrafish embryos, shown as defective thoracic duct formation, pericardial and truck edema, and altered sprouts of lymphatic vessels.</p>
<p><bold>Conclusion:</bold>
 RasGRP1 is involved in lymphangiogenesis in zebrafish.</p>
<p><bold>Significance:</bold>
 RasGRP1 has a physiological function in early development.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Biol Chem</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Biol. Chem</journal-id>
<journal-id journal-id-type="hwp">jbc</journal-id>
<journal-id journal-id-type="pmc">jbc</journal-id>
<journal-id journal-id-type="publisher-id">JBC</journal-id>
<journal-title-group><journal-title>The Journal of Biological Chemistry</journal-title>
</journal-title-group>
<issn pub-type="ppub">0021-9258</issn>
<issn pub-type="epub">1083-351X</issn>
<publisher><publisher-name>American Society for Biochemistry and Molecular Biology</publisher-name>
<publisher-loc>9650 Rockville Pike, Bethesda, MD 20814, U.S.A.</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23184941</article-id>
<article-id pub-id-type="pmc">3554906</article-id>
<article-id pub-id-type="publisher-id">M112.418202</article-id>
<article-id pub-id-type="doi">10.1074/jbc.M112.418202</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Developmental Biology</subject>
</subj-group>
</article-categories>
<title-group><article-title>The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish<xref ref-type="fn" rid="FN1">*</xref>
<xref ref-type="fn" rid="FN2"><sup><inline-graphic xlink:href="sbox.jpg"></inline-graphic>
</sup>
</xref>
</article-title>
<alt-title alt-title-type="short">RasGRP1 in Lymphatic Development</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Heng</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jin</surname>
<given-names>Ting</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Lin</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Fulong</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Rui</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pan</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Zhenzhen</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Yan</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1"><sup>1</sup>
</xref>
</contrib>
<aff id="aff1">From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>1</label>
 To whom correspondence should be addressed: <addr-line>Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Rd., Shanghai 200031, China.</addr-line>
 Tel.: <phone>86-21-54920916</phone>
; Fax: <fax>86-21-54920291</fax>
; E-mail: <email>ychen3@sibs.ac.cn</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>25</day>
<month>1</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>26</day>
<month>11</month>
<year>2012</year>
</pub-date>
<volume>288</volume>
<issue>4</issue>
<fpage>2355</fpage>
<lpage>2364</lpage>
<history><date date-type="received"><day>10</day>
<month>9</month>
<year>2012</year>
</date>
<date date-type="rev-recd"><day>21</day>
<month>11</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zbc00413002355.pdf"></self-uri>
<abstract abstract-type="teaser"><p><bold>Background:</bold>
 RasGRP1 is a protein involved in Ras activation, but its physiological function is largely unknown.</p>
<p><bold>Results:</bold>
 Knockdown of RasGRP1 impairs development of the lymphatic system in zebrafish embryos, shown as defective thoracic duct formation, pericardial and truck edema, and altered sprouts of lymphatic vessels.</p>
<p><bold>Conclusion:</bold>
 RasGRP1 is involved in lymphangiogenesis in zebrafish.</p>
<p><bold>Significance:</bold>
 RasGRP1 has a physiological function in early development.</p>
</abstract>
<abstract><p>The molecular basis of the lymphatic development remains largely unknown. Using zebrafish as a model, we discovered a novel role for the Ras guanine-releasing protein 1 (RasGRP1), a protein involved in Ras activation in lymphangiogenesis. Secondary lymphatic sprouts from the posterior cardinal vein give rise to thoracic duct which is the first lymphatic vessel in zebrafish. Knockdown of <italic>rasgrp1</italic>
 by injecting morpholino in zebrafish embryos impaired formation of thoracic duct accompanied by pericardial and truck edema, whereas blood vessel development of the embryos was largely unaffected. In <italic>rasgrp1</italic>
-knockdown embryos, the number of sprouts producing the string of parachordal lymphangioblast cells was reduced. Meanwhile the total number of the secondary sprouts was not changed. As a result, the number of venous intersegmental vessels was increased, whereas the number of lymphatic vessel was reduced at a later stage. The lymphatic developmental defects caused by <italic>rasgrp1</italic>
 knockdown could be rescued by ectopic expression of a constitutively active HRas. Further analysis revealed that RasGRP1 knockdown could synergize with <italic>flt4/vegfr3</italic>
 knockdown to induce defects in lymphangiogenesis. Taken together, this finding demonstrates a critical role for RasGRP1 in lymphatic development in zebrafish.</p>
</abstract>
<kwd-group><kwd>Development</kwd>
<kwd>Lymphangiogenesis</kwd>
<kwd>Ras</kwd>
<kwd>Vascular Biology</kwd>
<kwd>Vascular Endothelial Growth Factor (VEGF)</kwd>
<kwd>Zebrafish</kwd>
<kwd>PAQR10</kwd>
<kwd>RasGRP1</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E90 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 002E90 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:3554906
   |texte=   The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:23184941" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

The RAS Guanyl Nucleotide-releasing Protein RasGRP1 Is Involved in Lymphatic Development in Zebrafish*

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki