N-butanol Extract from Melilotus Suaveolens Ledeb Affects Pro- and Anti-Inflammatory Cytokines and Mediators
Identifieur interne : 003032 ( Ncbi/Curation ); précédent : 003031; suivant : 003033N-butanol Extract from Melilotus Suaveolens Ledeb Affects Pro- and Anti-Inflammatory Cytokines and Mediators
Auteurs : Lei Zhao ; Jun-Yan Tao ; Shu-Ling Zhang ; Feng Jin ; Ran Pang ; Ji-Hua Dong [République populaire de Chine]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2007.
Abstract
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DOI: 10.1093/ecam/nem165
PubMed: 18955281
PubMed Central: 2816390
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Lei Zhao<affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430072,</nlm:aff><wicri:noCountry code="subfield">430072</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>N</italic>-butanol Extract from <italic>Melilotus Suaveolens Ledeb</italic> Affects Pro- and Anti-Inflammatory Cytokines and Mediators</title><author><name sortKey="Zhao, Lei" sort="Zhao, Lei" uniqKey="Zhao L" first="Lei" last="Zhao">Lei Zhao</name><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation></author><author><name sortKey="Tao, Jun Yan" sort="Tao, Jun Yan" uniqKey="Tao J" first="Jun-Yan" last="Tao">Jun-Yan Tao</name><affiliation><nlm:aff id="AFF1">College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430072,</nlm:aff><wicri:noCountry code="subfield">430072</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Shu Ling" sort="Zhang, Shu Ling" uniqKey="Zhang S" first="Shu-Ling" last="Zhang">Shu-Ling Zhang</name><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation></author><author><name sortKey="Jin, Feng" sort="Jin, Feng" uniqKey="Jin F" first="Feng" last="Jin">Feng Jin</name><affiliation><nlm:aff wicri:cut=" and" id="AFF1">Department of Neurosurgery</nlm:aff></affiliation></author><author><name sortKey="Pang, Ran" sort="Pang, Ran" uniqKey="Pang R" first="Ran" last="Pang">Ran Pang</name><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation></author><author><name sortKey="Dong, Ji Hua" sort="Dong, Ji Hua" uniqKey="Dong J" first="Ji-Hua" last="Dong">Ji-Hua Dong</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Central Lab, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Lab, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18955281</idno><idno type="pmc">2816390</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816390</idno><idno type="RBID">PMC:2816390</idno><idno type="doi">10.1093/ecam/nem165</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">003E33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003E33</idno><idno type="wicri:Area/Pmc/Curation">003E32</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003E32</idno><idno type="wicri:Area/Pmc/Checkpoint">003C00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003C00</idno><idno type="wicri:Area/Ncbi/Merge">003032</idno><idno type="wicri:Area/Ncbi/Curation">003032</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>N</italic>-butanol Extract from <italic>Melilotus Suaveolens Ledeb</italic> Affects Pro- and Anti-Inflammatory Cytokines and Mediators</title><author><name sortKey="Zhao, Lei" sort="Zhao, Lei" uniqKey="Zhao L" first="Lei" last="Zhao">Lei Zhao</name><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation></author><author><name sortKey="Tao, Jun Yan" sort="Tao, Jun Yan" uniqKey="Tao J" first="Jun-Yan" last="Tao">Jun-Yan Tao</name><affiliation><nlm:aff id="AFF1">College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430072,</nlm:aff><wicri:noCountry code="subfield">430072</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Shu Ling" sort="Zhang, Shu Ling" uniqKey="Zhang S" first="Shu-Ling" last="Zhang">Shu-Ling Zhang</name><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation></author><author><name sortKey="Jin, Feng" sort="Jin, Feng" uniqKey="Jin F" first="Feng" last="Jin">Feng Jin</name><affiliation><nlm:aff wicri:cut=" and" id="AFF1">Department of Neurosurgery</nlm:aff></affiliation></author><author><name sortKey="Pang, Ran" sort="Pang, Ran" uniqKey="Pang R" first="Ran" last="Pang">Ran Pang</name><affiliation><nlm:aff id="AFF1">Department of Hepatology & Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022,</nlm:aff><wicri:noCountry code="subfield">430022</wicri:noCountry></affiliation></author><author><name sortKey="Dong, Ji Hua" sort="Dong, Ji Hua" uniqKey="Dong J" first="Ji-Hua" last="Dong">Ji-Hua Dong</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Central Lab, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Lab, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author></analytic><series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title><idno type="ISSN">1741-427X</idno><idno type="eISSN">1741-4288</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Melilotus suaveolens Ledeb</italic> is a traditional medicinal plant for treating inflammation-related disease. This explores the inner anti-inflammatory mechanism of <italic>n</italic>-butanol extract from <italic>M. suaveolens Ledeb</italic>. Inflammatory cellular model was established by lipopolysaccharide intervention on RAW264.7 cell line. Levels of secreted cytokines TNF-α, IL-1β, IL-6, NO and IL-10 in supernatant, mRNA expression of TNF-α, COX-2, iNOS and HO-1, protein expression of COX-2 and HO-1, activation of NF-κB and ingredients in the extract were assayed by ELISA, real time quantitative PCR, western blot, immunocytochemical test and HPLC fingerprint test, respectively. As a result, the extract could not only markedly reduce the production of pro-inflammatory mediators to different extents by blocking NF-κB activation but also promote the release of anti-inflammatory mediator HO-1 significantly. Each 1 g extract contained 0.023531 mg coumarin and another two high polar ingredients, probably saponins. It can be concluded that the extract has similar effects on antagonizing pro-inflammatory mediators and cytokines like Dexamethasone, and has effects on promoting the production of anti-inflammatory mediators.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zoltan, Ot" uniqKey="Zoltan O">OT Zoltan</name></author><author><name sortKey="Foldi, M" uniqKey="Foldi M">M Foldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pastura, G" uniqKey="Pastura G">G Pastura</name></author><author><name sortKey="Mesiti, M" uniqKey="Mesiti M">M Mesiti</name></author><author><name sortKey="Saitta, M" uniqKey="Saitta M">M Saitta</name></author><author><name sortKey="Romeo, D" uniqKey="Romeo D">D Romeo</name></author><author><name sortKey="Settineri, N" uniqKey="Settineri N">N Settineri</name></author><author><name sortKey="Maisano, R" uniqKey="Maisano R">R Maisano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Podkolzin, Aa" uniqKey="Podkolzin A">AA Podkolzin</name></author><author><name sortKey="Dontsov, Vi" uniqKey="Dontsov V">VI Dontsov</name></author><author><name sortKey="Sychev, Ia" uniqKey="Sychev I">IA Sychev</name></author><author><name sortKey="Kobeleva, Giu" uniqKey="Kobeleva G">GIu Kobeleva</name></author><author><name sortKey="Kharchenko, On" uniqKey="Kharchenko O">ON Kharchenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plesca Manea, L" uniqKey="Plesca Manea L">L Plesca-Manea</name></author><author><name sortKey="Parvu, Ae" uniqKey="Parvu A">AE Parvu</name></author><author><name sortKey="Parvu, M" uniqKey="Parvu M">M Parvu</name></author><author><name sortKey="Taamas, M" uniqKey="Taamas M">M Taamas</name></author><author><name sortKey="Buia, R" uniqKey="Buia R">R Buia</name></author><author><name sortKey="Puia, M" uniqKey="Puia M">M Puia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brasier, Ar" uniqKey="Brasier A">AR Brasier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsatsanis, C" uniqKey="Tsatsanis C">C Tsatsanis</name></author><author><name sortKey="Androulidaki, A" uniqKey="Androulidaki A">A Androulidaki</name></author><author><name sortKey="Venihaki, M" uniqKey="Venihaki M">M Venihaki</name></author><author><name sortKey="Margioris, An" uniqKey="Margioris A">AN Margioris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korhonen, R" uniqKey="Korhonen R">R Korhonen</name></author><author><name sortKey="Lahti, A" uniqKey="Lahti A">A Lahti</name></author><author><name sortKey="Kankaanranta, H" uniqKey="Kankaanranta H">H Kankaanranta</name></author><author><name sortKey="Moilanen, E" uniqKey="Moilanen E">E Moilanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aggarwal, Bb" uniqKey="Aggarwal B">BB Aggarwal</name></author><author><name sortKey="Shishodia, S" uniqKey="Shishodia S">S Shishodia</name></author><author><name sortKey="Sandur, Sk" uniqKey="Sandur S">SK Sandur</name></author><author><name sortKey="Pandey, Mk" uniqKey="Pandey M">MK Pandey</name></author><author><name sortKey="Sethi, G" uniqKey="Sethi G">G Sethi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harizi, H" uniqKey="Harizi H">H Harizi</name></author><author><name sortKey="Gualde, N" uniqKey="Gualde N">N Gualde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abraham, Ng" uniqKey="Abraham N">NG Abraham</name></author><author><name sortKey="Asija, A" uniqKey="Asija A">A Asija</name></author><author><name sortKey="Drummond, G" uniqKey="Drummond G">G Drummond</name></author><author><name sortKey="Peterson, S" uniqKey="Peterson S">S Peterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prawan, A" uniqKey="Prawan A">A Prawan</name></author><author><name sortKey="Kundu, Jk" uniqKey="Kundu J">JK Kundu</name></author><author><name sortKey="Surh, Yj" uniqKey="Surh Y">YJ Surh</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Hj" uniqKey="Lee H">HJ Lee</name></author><author><name sortKey="Hyun, Ea" uniqKey="Hyun E">EA Hyun</name></author><author><name sortKey="Yoon, Wj" uniqKey="Yoon W">WJ Yoon</name></author><author><name sortKey="Kim, Bh" uniqKey="Kim B">BH Kim</name></author><author><name sortKey="Rhee, Mh" uniqKey="Rhee M">MH Rhee</name></author><author><name sortKey="Kang, Hk" uniqKey="Kang H">HK Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Km" uniqKey="Kim K">KM Kim</name></author><author><name sortKey="Kwon, Yg" uniqKey="Kwon Y">YG Kwon</name></author><author><name sortKey="Chung, Ht" uniqKey="Chung H">HT Chung</name></author><author><name sortKey="Yun, Yg" uniqKey="Yun Y">YG Yun</name></author><author><name sortKey="Pae, Ho" uniqKey="Pae H">HO Pae</name></author><author><name sortKey="Han, Ja" uniqKey="Han J">JA Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qi, Lw" uniqKey="Qi L">LW Qi</name></author><author><name sortKey="Yu, Qt" uniqKey="Yu Q">QT Yu</name></author><author><name sortKey="Li, P" uniqKey="Li P">P Li</name></author><author><name sortKey="Li, Sl" uniqKey="Li S">SL Li</name></author><author><name sortKey="Wang, Yx" uniqKey="Wang Y">YX Wang</name></author><author><name sortKey="Sheng, Lh" uniqKey="Sheng L">LH Sheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shao, Bm" uniqKey="Shao B">BM Shao</name></author><author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name></author><author><name sortKey="Dai, H" uniqKey="Dai H">H Dai</name></author><author><name sortKey="Tu, P" uniqKey="Tu P">P Tu</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Gao, Xm" uniqKey="Gao X">XM Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selloum, L" uniqKey="Selloum L">L Selloum</name></author><author><name sortKey="Bouriche, H" uniqKey="Bouriche H">H Bouriche</name></author><author><name sortKey="Tigrine, C" uniqKey="Tigrine C">C Tigrine</name></author><author><name sortKey="Boudoukha, C" uniqKey="Boudoukha C">C Boudoukha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franchimont, D" uniqKey="Franchimont D">D Franchimont</name></author><author><name sortKey="Martens, H" uniqKey="Martens H">H Martens</name></author><author><name sortKey="Hagelstein, Mt" uniqKey="Hagelstein M">MT Hagelstein</name></author><author><name sortKey="Louis, E" uniqKey="Louis E">E Louis</name></author><author><name sortKey="Dewe, W" uniqKey="Dewe W">W Dewe</name></author><author><name sortKey="Chrousos, Gp" uniqKey="Chrousos G">GP Chrousos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name></author><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name></author><author><name sortKey="Zhang, Sl" uniqKey="Zhang S">SL Zhang</name></author><author><name sortKey="Xiang, Jz" uniqKey="Xiang J">JZ Xiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name></author><author><name sortKey="Gan, Ap" uniqKey="Gan A">AP Gan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chavan, P" uniqKey="Chavan P">P Chavan</name></author><author><name sortKey="Joshi, K" uniqKey="Joshi K">K Joshi</name></author><author><name sortKey="Patwardhan, B" uniqKey="Patwardhan B">B Patwardhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaphle, K" uniqKey="Kaphle K">K Kaphle</name></author><author><name sortKey="Wu, Ls" uniqKey="Wu L">LS Wu</name></author><author><name sortKey="Yang, Ny" uniqKey="Yang N">NY Yang</name></author><author><name sortKey="Lin, Jh" uniqKey="Lin J">JH Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name></author><author><name sortKey="Tao, Jy" uniqKey="Tao J">JY Tao</name></author><author><name sortKey="Zhang, Sl" uniqKey="Zhang S">SL Zhang</name></author><author><name sortKey="Pang, R" uniqKey="Pang R">R Pang</name></author><author><name sortKey="Jin, F" uniqKey="Jin F">F Jin</name></author><author><name sortKey="Dong, Jh" uniqKey="Dong J">JH 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