Blinding Techniques in Randomized Controlled Trials of Laser Therapy: An Overview and Possible Solution
Identifieur interne : 003031 ( Ncbi/Curation ); précédent : 003030; suivant : 003032Blinding Techniques in Randomized Controlled Trials of Laser Therapy: An Overview and Possible Solution
Auteurs : Ian Relf ; Roberta Chow [Australie] ; Marie PirottaSource :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2007.
Abstract
Low-level laser therapy has evidence accumulating about its effectiveness in a variety of medical conditions. We reviewed 51 double blind randomized controlled trials (RCTs) of laser treatment. Analysis revealed 58% of trials showed benefit of laser over placebo. However, less than 5% of the trials had addressed beam disguise or allocation concealment in the laser machines used. Many of the trials used blinding methods that rely on staff cooperation and are therefore open to interference or bias. This indicates significant deficiencies in laser trial methodology. We report the development and preliminary testing of a novel laser machine that can blind both patient and operator to treatment allocation without staff participation. The new laser machine combines sealed preset and non-bypassable randomization codes, decoy lights and sound, and a conical perspex tip to overcome laser diode glow detection.
Url:
DOI: 10.1093/ecam/nem085
PubMed: 18955233
PubMed Central: 2586311
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004718
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :004717
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003B82
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003031
Links to Exploration step
PMC:2586311Curation
No country items
Ian Relf<affiliation><nlm:aff wicri:cut=", and" id="AFF1">Department of General Practice, University of Melbourne, 200 Berkeley Street Carlton 3053, Victoria</nlm:aff>
<wicri:noCountry code="subfield">Victoria</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="AFF1">Department of General Practice, University of Melbourne, 200 Berkeley Street Carlton 3053, Victoria</nlm:aff>
<wicri:noCountry code="subfield">Victoria</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Blinding Techniques in Randomized Controlled Trials of Laser Therapy: An Overview and Possible Solution</title>
<author><name sortKey="Relf, Ian" sort="Relf, Ian" uniqKey="Relf I" first="Ian" last="Relf">Ian Relf</name>
<affiliation><nlm:aff wicri:cut=", and" id="AFF1">Department of General Practice, University of Melbourne, 200 Berkeley Street Carlton 3053, Victoria</nlm:aff>
<wicri:noCountry code="subfield">Victoria</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chow, Roberta" sort="Chow, Roberta" uniqKey="Chow R" first="Roberta" last="Chow">Roberta Chow</name>
<affiliation wicri:level="1"><nlm:aff id="AFF1">Private Medical Practice, NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Private Medical Practice, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pirotta, Marie" sort="Pirotta, Marie" uniqKey="Pirotta M" first="Marie" last="Pirotta">Marie Pirotta</name>
<affiliation><nlm:aff wicri:cut=", and" id="AFF1">Department of General Practice, University of Melbourne, 200 Berkeley Street Carlton 3053, Victoria</nlm:aff>
<wicri:noCountry code="subfield">Victoria</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18955233</idno>
<idno type="pmc">2586311</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586311</idno>
<idno type="RBID">PMC:2586311</idno>
<idno type="doi">10.1093/ecam/nem085</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">004718</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004718</idno>
<idno type="wicri:Area/Pmc/Curation">004717</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004717</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003B82</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003B82</idno>
<idno type="wicri:Area/Ncbi/Merge">003031</idno>
<idno type="wicri:Area/Ncbi/Curation">003031</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Blinding Techniques in Randomized Controlled Trials of Laser Therapy: An Overview and Possible Solution</title>
<author><name sortKey="Relf, Ian" sort="Relf, Ian" uniqKey="Relf I" first="Ian" last="Relf">Ian Relf</name>
<affiliation><nlm:aff wicri:cut=", and" id="AFF1">Department of General Practice, University of Melbourne, 200 Berkeley Street Carlton 3053, Victoria</nlm:aff>
<wicri:noCountry code="subfield">Victoria</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chow, Roberta" sort="Chow, Roberta" uniqKey="Chow R" first="Roberta" last="Chow">Roberta Chow</name>
<affiliation wicri:level="1"><nlm:aff id="AFF1">Private Medical Practice, NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Private Medical Practice, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pirotta, Marie" sort="Pirotta, Marie" uniqKey="Pirotta M" first="Marie" last="Pirotta">Marie Pirotta</name>
<affiliation><nlm:aff wicri:cut=", and" id="AFF1">Department of General Practice, University of Melbourne, 200 Berkeley Street Carlton 3053, Victoria</nlm:aff>
<wicri:noCountry code="subfield">Victoria</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title>
<idno type="ISSN">1741-427X</idno>
<idno type="eISSN">1741-4288</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Low-level laser therapy has evidence accumulating about its effectiveness in a variety of medical conditions. We reviewed 51 double blind randomized controlled trials (RCTs) of laser treatment. Analysis revealed 58% of trials showed benefit of laser over placebo. However, less than 5% of the trials had addressed beam disguise or allocation concealment in the laser machines used. Many of the trials used blinding methods that rely on staff cooperation and are therefore open to interference or bias. This indicates significant deficiencies in laser trial methodology. We report the development and preliminary testing of a novel laser machine that can blind both patient and operator to treatment allocation without staff participation. The new laser machine combines sealed preset and non-bypassable randomization codes, decoy lights and sound, and a conical perspex tip to overcome laser diode glow detection.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003031 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 003031 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:2586311 |texte= Blinding Techniques in Randomized Controlled Trials of Laser Therapy: An Overview and Possible Solution }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:18955233" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |