Older Breast Cancer Survivors: Factors Associated with Self-reported Symptoms of Persistent Lymphedema Over 7-years of Follow-up
Identifieur interne : 003788 ( Ncbi/Checkpoint ); précédent : 003787; suivant : 003789Older Breast Cancer Survivors: Factors Associated with Self-reported Symptoms of Persistent Lymphedema Over 7-years of Follow-up
Auteurs : Kerri M. Clough-Gorr [États-Unis, Suisse] ; Patricia A. Ganz [États-Unis] ; Rebecca A. Silliman [États-Unis]Source :
- The breast journal [ 1075-122X ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs du sein.
- mortalité : Tumeurs du sein.
- étiologie : Lymphoedème.
- Femelle, Humains, Santé mentale, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Survivants, Tumeurs du sein, Études de suivi, Études longitudinales.
English descriptors
- KwdEn :
- MESH :
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- mortality : Breast Neoplasms.
- pathology : Breast Neoplasms.
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Longitudinal Studies, Mental Health, Neoplasm Staging, Survivors.
Abstract
Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time. For older women (over 50% of breast cancer cases) it means living with the potential for long-term complications of persistent lymphedema in conjunction with the common diseases and disabilities of aging over survivorship.
We identified women ≥65-years diagnosed with primary stage I-IIIA breast cancer. Data were collected over 7-years of follow-up from consenting patients’ medical records and telephone interviews. Data collected included self-reported symptoms of persistent lymphedema, breast cancer characteristics, and selected sociodemographic and health-related characteristics.
The overall prevalence of symptoms of persistent lymphedema was 36% over 7-years of follow-up. Having stage II or III (OR=1.77, 95%CI 1.07–2.93) breast cancer and having a BMI>30 (OR=3.04, 95%CI 1.69–5.45) were statistically significantly predictive of symptoms of persistent lymphedema. Women ≥80-years were less likely to report symptoms of persistent lymphedema when compared to younger women (OR=0.44, 95%CI 0.18–0.95). Women with symptoms of persistent lymphedema consistently reported worse general mental health and physical function.
Symptoms of persistent lymphedema were common in this population of older breast cancer survivors and had a noticeable effect on both physical function and general mental health. Our findings provide evidence of the impact of symptoms of persistent lymphedema on the quality of survivorship of older women. Clinical and research efforts focused on risk factors for symptoms of persistent lymphedema in older breast cancer survivors may lead to preventative and therapeutic measures that help maintain their health and well-being over increasing periods of survivorship.
Url:
DOI: 10.1111/j.1524-4741.2009.00878.x
PubMed: 19968661
PubMed Central: 2873157
Affiliations:
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Clough-Gorr</name><affiliation wicri:level="2"><nlm:aff id="A1"> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> Department of Geriatrics, Inselspital University of Bern Hospital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Department of Geriatrics, Inselspital University of Bern Hospital, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="2"><nlm:aff id="A4"> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. 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Clough-Gorr</name><affiliation wicri:level="2"><nlm:aff id="A1"> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> Department of Geriatrics, Inselspital University of Bern Hospital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Department of Geriatrics, Inselspital University of Bern Hospital, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="2"><nlm:aff id="A4"> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">The breast journal</title><idno type="ISSN">1075-122X</idno><idno type="eISSN">1524-4741</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (mortality)</term><term>Breast Neoplasms (pathology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Lymphedema (etiology)</term><term>Mental Health</term><term>Neoplasm Staging</term><term>Survivors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lymphoedème (étiologie)</term><term>Santé mentale</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survivants</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (mortalité)</term><term>Études de suivi</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Mental Health</term><term>Neoplasm Staging</term><term>Survivors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Santé mentale</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survivants</term><term>Tumeurs du sein</term><term>Études de suivi</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title><p id="P1">Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time. For older women (over 50% of breast cancer cases) it means living with the potential for long-term complications of persistent lymphedema in conjunction with the common diseases and disabilities of aging over survivorship.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We identified women ≥65-years diagnosed with primary stage I-IIIA breast cancer. Data were collected over 7-years of follow-up from consenting patients’ medical records and telephone interviews. Data collected included self-reported symptoms of persistent lymphedema, breast cancer characteristics, and selected sociodemographic and health-related characteristics.</p></sec><sec id="S3"><title>Results</title><p id="P3">The overall prevalence of symptoms of persistent lymphedema was 36% over 7-years of follow-up. Having stage II or III (OR=1.77, 95%CI 1.07–2.93) breast cancer and having a BMI>30 (OR=3.04, 95%CI 1.69–5.45) were statistically significantly predictive of symptoms of persistent lymphedema. Women ≥80-years were less likely to report symptoms of persistent lymphedema when compared to younger women (OR=0.44, 95%CI 0.18–0.95). Women with symptoms of persistent lymphedema consistently reported worse general mental health and physical function.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Symptoms of persistent lymphedema were common in this population of older breast cancer survivors and had a noticeable effect on both physical function and general mental health. Our findings provide evidence of the impact of symptoms of persistent lymphedema on the quality of survivorship of older women. Clinical and research efforts focused on risk factors for symptoms of persistent lymphedema in older breast cancer survivors may lead to preventative and therapeutic measures that help maintain their health and well-being over increasing periods of survivorship.</p></sec></div></front></TEI><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country><region><li>Californie</li><li>Canton de Berne</li><li>Massachusetts</li></region><settlement><li>Berne</li></settlement></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Clough Gorr, Kerri M" sort="Clough Gorr, Kerri M" uniqKey="Clough Gorr K" first="Kerri M." last="Clough-Gorr">Kerri M. Clough-Gorr</name></region><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Clough Gorr, Kerri M" sort="Clough Gorr, Kerri M" uniqKey="Clough Gorr K" first="Kerri M." last="Clough-Gorr">Kerri M. Clough-Gorr</name></region><name sortKey="Clough Gorr, Kerri M" sort="Clough Gorr, Kerri M" uniqKey="Clough Gorr K" first="Kerri M." last="Clough-Gorr">Kerri M. Clough-Gorr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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