Older Breast Cancer Survivors: Factors Associated with Self-reported Symptoms of Persistent Lymphedema Over 7-years of Follow-up
Identifieur interne : 003A26 ( Pmc/Curation ); précédent : 003A25; suivant : 003A27Older Breast Cancer Survivors: Factors Associated with Self-reported Symptoms of Persistent Lymphedema Over 7-years of Follow-up
Auteurs : Kerri M. Clough-Gorr [États-Unis, Suisse] ; Patricia A. Ganz [États-Unis] ; Rebecca A. Silliman [États-Unis]Source :
- The breast journal [ 1075-122X ] ; 2009.
Abstract
Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time. For older women (over 50% of breast cancer cases) it means living with the potential for long-term complications of persistent lymphedema in conjunction with the common diseases and disabilities of aging over survivorship.
We identified women ≥65-years diagnosed with primary stage I-IIIA breast cancer. Data were collected over 7-years of follow-up from consenting patients’ medical records and telephone interviews. Data collected included self-reported symptoms of persistent lymphedema, breast cancer characteristics, and selected sociodemographic and health-related characteristics.
The overall prevalence of symptoms of persistent lymphedema was 36% over 7-years of follow-up. Having stage II or III (OR=1.77, 95%CI 1.07–2.93) breast cancer and having a BMI>30 (OR=3.04, 95%CI 1.69–5.45) were statistically significantly predictive of symptoms of persistent lymphedema. Women ≥80-years were less likely to report symptoms of persistent lymphedema when compared to younger women (OR=0.44, 95%CI 0.18–0.95). Women with symptoms of persistent lymphedema consistently reported worse general mental health and physical function.
Symptoms of persistent lymphedema were common in this population of older breast cancer survivors and had a noticeable effect on both physical function and general mental health. Our findings provide evidence of the impact of symptoms of persistent lymphedema on the quality of survivorship of older women. Clinical and research efforts focused on risk factors for symptoms of persistent lymphedema in older breast cancer survivors may lead to preventative and therapeutic measures that help maintain their health and well-being over increasing periods of survivorship.
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DOI: 10.1111/j.1524-4741.2009.00878.x
PubMed: 19968661
PubMed Central: 2873157
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Clough-Gorr</name><affiliation wicri:level="2"><nlm:aff id="A1"> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Geriatrics, Inselspital University of Bern Hospital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Department of Geriatrics, Inselspital University of Bern Hospital, Bern</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern</wicri:regionArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="2"><nlm:aff id="A4"> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19968661</idno><idno type="pmc">2873157</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873157</idno><idno type="RBID">PMC:2873157</idno><idno type="doi">10.1111/j.1524-4741.2009.00878.x</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">003A27</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003A27</idno><idno type="wicri:Area/Pmc/Curation">003A26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003A26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Older Breast Cancer Survivors: Factors Associated with Self-reported Symptoms of Persistent Lymphedema Over 7-years of Follow-up</title><author><name sortKey="Clough Gorr, Kerri M" sort="Clough Gorr, Kerri M" uniqKey="Clough Gorr K" first="Kerri M." last="Clough-Gorr">Kerri M. Clough-Gorr</name><affiliation wicri:level="2"><nlm:aff id="A1"> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Geriatrics, Inselspital University of Bern Hospital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> Department of Geriatrics, Inselspital University of Bern Hospital, Bern</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern</wicri:regionArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="2"><nlm:aff id="A4"> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">The breast journal</title><idno type="ISSN">1075-122X</idno><idno type="eISSN">1524-4741</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title><p id="P1">Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time. For older women (over 50% of breast cancer cases) it means living with the potential for long-term complications of persistent lymphedema in conjunction with the common diseases and disabilities of aging over survivorship.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We identified women ≥65-years diagnosed with primary stage I-IIIA breast cancer. Data were collected over 7-years of follow-up from consenting patients’ medical records and telephone interviews. Data collected included self-reported symptoms of persistent lymphedema, breast cancer characteristics, and selected sociodemographic and health-related characteristics.</p></sec><sec id="S3"><title>Results</title><p id="P3">The overall prevalence of symptoms of persistent lymphedema was 36% over 7-years of follow-up. Having stage II or III (OR=1.77, 95%CI 1.07–2.93) breast cancer and having a BMI>30 (OR=3.04, 95%CI 1.69–5.45) were statistically significantly predictive of symptoms of persistent lymphedema. Women ≥80-years were less likely to report symptoms of persistent lymphedema when compared to younger women (OR=0.44, 95%CI 0.18–0.95). Women with symptoms of persistent lymphedema consistently reported worse general mental health and physical function.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Symptoms of persistent lymphedema were common in this population of older breast cancer survivors and had a noticeable effect on both physical function and general mental health. Our findings provide evidence of the impact of symptoms of persistent lymphedema on the quality of survivorship of older women. Clinical and research efforts focused on risk factors for symptoms of persistent lymphedema in older breast cancer survivors may lead to preventative and therapeutic measures that help maintain their health and well-being over increasing periods of survivorship.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9505539</journal-id><journal-id journal-id-type="pubmed-jr-id">22310</journal-id><journal-id journal-id-type="nlm-ta">Breast J</journal-id><journal-id journal-id-type="iso-abbrev">Breast J</journal-id><journal-title-group><journal-title>The breast journal</journal-title></journal-title-group><issn pub-type="ppub">1075-122X</issn><issn pub-type="epub">1524-4741</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19968661</article-id><article-id pub-id-type="pmc">2873157</article-id><article-id pub-id-type="doi">10.1111/j.1524-4741.2009.00878.x</article-id><article-id pub-id-type="manuscript">NIHMS159912</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Older Breast Cancer Survivors: Factors Associated with Self-reported Symptoms of Persistent Lymphedema Over 7-years of Follow-up</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Clough-Gorr</surname><given-names>Kerri M.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ganz</surname><given-names>Patricia A.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Silliman</surname><given-names>Rebecca A.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, MA</aff><aff id="A2"><label>2</label> Department of Geriatrics, Inselspital University of Bern Hospital, Bern, Switzerland</aff><aff id="A3"><label>3</label> University Department of Geriatrics, Spital Netz Bern Ziegler, Bern, Switzerland</aff><aff id="A4"><label>4</label> University of California at Los Angeles Schools of Medicine and Public Health, Los Angeles, CA</aff><aff id="A5"><label>5</label> Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA</aff><author-notes><corresp id="FN1">Corresponding Author: Kerri M. Clough-Gorr, Boston University Medical Center, 88 East Newton Street, Robinson 2, Boston, MA 02118, Telephone: (617) 638-6101, <email>kmclough@bu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>12</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>24</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="ppub"><season>Mar-Apr</season><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2011</year></pub-date><volume>16</volume><issue>2</issue><fpage>147</fpage><lpage>155</lpage><abstract><sec id="S1"><title>Introduction</title><p id="P1">Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time. For older women (over 50% of breast cancer cases) it means living with the potential for long-term complications of persistent lymphedema in conjunction with the common diseases and disabilities of aging over survivorship.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We identified women ≥65-years diagnosed with primary stage I-IIIA breast cancer. Data were collected over 7-years of follow-up from consenting patients’ medical records and telephone interviews. Data collected included self-reported symptoms of persistent lymphedema, breast cancer characteristics, and selected sociodemographic and health-related characteristics.</p></sec><sec id="S3"><title>Results</title><p id="P3">The overall prevalence of symptoms of persistent lymphedema was 36% over 7-years of follow-up. Having stage II or III (OR=1.77, 95%CI 1.07–2.93) breast cancer and having a BMI>30 (OR=3.04, 95%CI 1.69–5.45) were statistically significantly predictive of symptoms of persistent lymphedema. Women ≥80-years were less likely to report symptoms of persistent lymphedema when compared to younger women (OR=0.44, 95%CI 0.18–0.95). Women with symptoms of persistent lymphedema consistently reported worse general mental health and physical function.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Symptoms of persistent lymphedema were common in this population of older breast cancer survivors and had a noticeable effect on both physical function and general mental health. Our findings provide evidence of the impact of symptoms of persistent lymphedema on the quality of survivorship of older women. Clinical and research efforts focused on risk factors for symptoms of persistent lymphedema in older breast cancer survivors may lead to preventative and therapeutic measures that help maintain their health and well-being over increasing periods of survivorship.</p></sec></abstract><kwd-group><kwd>Breast cancer</kwd><kwd>lymphedema</kwd><kwd>older women</kwd><kwd>persistent lymphedema</kwd><kwd>survivor</kwd><kwd>symptoms</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA106979-05 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA084506-04 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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