Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.
Identifieur interne : 00D672 ( Main/Merge ); précédent : 00D671; suivant : 00D673Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis.
Auteurs : N M Mckechnie [Royaume-Uni] ; G. Braun ; V. Connor ; S. Kl Ger ; D W Taylor ; R A Alexander ; C E GilbertSource :
- Investigative ophthalmology & visual science [ 0146-0404 ] ; 1993.
Descripteurs français
- KwdFr :
- ADN des protozoaires, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (immunologie), Antigènes d'helminthe (immunologie), Autoanticorps (immunologie), Femelle, Filariose lymphatique (immunologie), Humains, Hybridation d'acides nucléiques, Lapins, Mâle, Onchocercose oculaire (anatomopathologie), Onchocercose oculaire (immunologie), Réactions croisées (immunologie), Technique de Western, Techniques immunoenzymatiques, Électrophorèse sur gel de polyacrylamide.
- MESH :
- anatomopathologie : Onchocercose oculaire.
- immunologie : Anticorps antihelminthe, Antigènes d'helminthe, Autoanticorps, Filariose lymphatique, Onchocercose oculaire, Réactions croisées.
- ADN des protozoaires, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Hybridation d'acides nucléiques, Lapins, Mâle, Technique de Western, Techniques immunoenzymatiques, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Helminth (immunology), Antigens, Helminth (immunology), Autoantibodies (immunology), Blotting, Western, Cross Reactions (immunology), DNA, Protozoan, Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (immunology), Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Nucleic Acid Hybridization, Onchocerciasis, Ocular (immunology), Onchocerciasis, Ocular (pathology), Rabbits.
- MESH :
- chemical , immunology : Antibodies, Helminth, Antigens, Helminth, Autoantibodies.
- immunology : Cross Reactions, Elephantiasis, Filarial, Onchocerciasis, Ocular.
- pathology : Onchocerciasis, Ocular.
- Adult, Animals, Blotting, Western, DNA, Protozoan, Electrophoresis, Polyacrylamide Gel, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Nucleic Acid Hybridization, Rabbits.
Abstract
Onchocerca volvulus, a filarial worm, is a major cause of infectious blindness and inflammatory eye disease. An autoimmune cause for ocular onchocerciasis has been suggested since the identification of a recombinant antigen of O. volvulus that shows immunologic cross-reactivity with a host ocular component of 44,000 M(r). The aim of this study was to establish the distribution of the cross-reactive antigens in both host tissues and the parasite, and to determine if significant autoantibody responses to the host antigen could be detected in infected persons.
PubMed: 8360022
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pubmed:8360022Le document en format XML
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<term>Antigens, Helminth (immunology)</term>
<term>Autoantibodies (immunology)</term>
<term>Blotting, Western</term>
<term>Cross Reactions (immunology)</term>
<term>DNA, Protozoan</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoenzyme Techniques</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nucleic Acid Hybridization</term>
<term>Onchocerciasis, Ocular (immunology)</term>
<term>Onchocerciasis, Ocular (pathology)</term>
<term>Rabbits</term>
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<term>Anticorps antihelminthe (immunologie)</term>
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<term>Autoanticorps (immunologie)</term>
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<term>Filariose lymphatique (immunologie)</term>
<term>Humains</term>
<term>Hybridation d'acides nucléiques</term>
<term>Lapins</term>
<term>Mâle</term>
<term>Onchocercose oculaire (anatomopathologie)</term>
<term>Onchocercose oculaire (immunologie)</term>
<term>Réactions croisées (immunologie)</term>
<term>Technique de Western</term>
<term>Techniques immunoenzymatiques</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
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<term>Antigens, Helminth</term>
<term>Autoantibodies</term>
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<term>Antigènes d'helminthe</term>
<term>Autoanticorps</term>
<term>Filariose lymphatique</term>
<term>Onchocercose oculaire</term>
<term>Réactions croisées</term>
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<term>Elephantiasis, Filarial</term>
<term>Onchocerciasis, Ocular</term>
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<term>DNA, Protozoan</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoenzyme Techniques</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nucleic Acid Hybridization</term>
<term>Rabbits</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">Onchocerca volvulus, a filarial worm, is a major cause of infectious blindness and inflammatory eye disease. An autoimmune cause for ocular onchocerciasis has been suggested since the identification of a recombinant antigen of O. volvulus that shows immunologic cross-reactivity with a host ocular component of 44,000 M(r). The aim of this study was to establish the distribution of the cross-reactive antigens in both host tissues and the parasite, and to determine if significant autoantibody responses to the host antigen could be detected in infected persons.</div>
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