LymphedemaV1, Main, Merge, bibRecord, 007900

One-sided limb lymphedema in a liver transplant recipient receiving Sirolimus

Identifieur interne : 007900 ( Main/Merge ); précédent : 007899; suivant : 007901

One-sided limb lymphedema in a liver transplant recipient receiving Sirolimus

Auteurs : M. Van Onna [Belgique] ; A. Geerts [Belgique] ; H. Van Vlierberghe [Belgique] ; F. Berrevoet [Belgique] ; B. De Hemptinne [Belgique] ; R. Troisi [Belgique] ; I. Colle [Belgique]

Source :

Acta gastro-enterologica belgica [ 0001-5644 ] ; 2007.

RBID : Pascal:08-0121554

Descripteurs français

Pascal (Inist)
- Sirolimus, Membre, Lymphoedème, Foie, Homotransplantation, Oedème, Toxicité, Transplantation, Antibactérien, Antibiotique, Anticancéreux, Immunodépresseur, Traitement.
Wicri :
- topic : Antibiotique.

English descriptors

KwdEn :
- Antibacterial agent, Antibiotic, Antineoplastic agent, Edema, Homotransplantation, Immunosuppressive agent, Limb, Liver, Lymphedema, Sirolimus, Toxicity, Transplantation, Treatment.

Abstract

Sirolimus (SRL) is associated with many side effects including hypercholesterolemia, anaemia, impaired wound healing and abnormal liver function tests. Limb lymphedema has only been reported several times in renal transplant recipients. We present a case of lower limb lymphedema that occurred in a 59-year-old liver transplant recipient after being on a SRL regimen for seven months. Extensive diagnostic investigations could not reveal signs of infection, venous obstruction or malignancy. After discontinuation of SRL, the lymphedema gradually resolved during the next three months. The pathologic mechanism behind this phenomenon is unknown, but antiangiogenetic and antiproliferative properties of SRL have been hold responsible. Further studies are necessary to explain this rare side effect.

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Pascal:08-0121554

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibacterial agent</term>
<term>Antibiotic</term>
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<term>Edema</term>
<term>Homotransplantation</term>
<term>Immunosuppressive agent</term>
<term>Limb</term>
<term>Liver</term>
<term>Lymphedema</term>
<term>Sirolimus</term>
<term>Toxicity</term>
<term>Transplantation</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Sirolimus</term>
<term>Membre</term>
<term>Lymphoedème</term>
<term>Foie</term>
<term>Homotransplantation</term>
<term>Oedème</term>
<term>Toxicité</term>
<term>Transplantation</term>
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<front><div type="abstract" xml:lang="en">Sirolimus (SRL) is associated with many side effects including hypercholesterolemia, anaemia, impaired wound healing and abnormal liver function tests. Limb lymphedema has only been reported several times in renal transplant recipients. We present a case of lower limb lymphedema that occurred in a 59-year-old liver transplant recipient after being on a SRL regimen for seven months. Extensive diagnostic investigations could not reveal signs of infection, venous obstruction or malignancy. After discontinuation of SRL, the lymphedema gradually resolved during the next three months. The pathologic mechanism behind this phenomenon is unknown, but antiangiogenetic and antiproliferative properties of SRL have been hold responsible. Further studies are necessary to explain this rare side effect.</div>
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<affiliations><list><country><li>Belgique</li>
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<tree><country name="Belgique"><noRegion><name sortKey="Van Onna, M" sort="Van Onna, M" uniqKey="Van Onna M" first="M." last="Van Onna">M. Van Onna</name>
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One-sided limb lymphedema in a liver transplant recipient receiving Sirolimus

One-sided limb lymphedema in a liver transplant recipient receiving Sirolimus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri