Analysis of the correlation between P53 and Cox-2 expression and prognosis in esophageal cancer
Identifieur interne : 002148 ( Main/Exploration ); précédent : 002147; suivant : 002149Analysis of the correlation between P53 and Cox-2 expression and prognosis in esophageal cancer
Auteurs : Jun Chen [République populaire de Chine] ; Fang Wu [République populaire de Chine] ; Hong-Lei Pei [République populaire de Chine] ; Wen-Dong Gu [République populaire de Chine] ; Zhong-Hua Ning [République populaire de Chine] ; Ying-Jie Shao [République populaire de Chine] ; Jin Huang [République populaire de Chine]Source :
- Oncology Letters [ 1792-1074 ] ; 2015.
Abstract
The present study aimed to explore the importance of P53 and Cox-2 protein expression in esophageal cancer and assess their influence on prognosis. The expression of P53 and Cox-2 was assessed in esophageal cancer samples from 195 patients subjected to radical surgery at Changzhou First People's Hospital (Changzhou, China) between May 2010 and December 2011. Expression of P53 and Cox-2 proteins were detected in 60.5% (118/195) and 69.7% (136/195) of the samples, respectively, and were co-expressed in 43.1% (84/195) of the samples. A correlation was identified between P53 expression and overall survival (OS) (P=0.0351) as well as disease-free survival (DFS) (P=0.0307). In addition, the co-expression of P53 and Cox-2 also correlated with OS (P=0.0040) and DFS (P=0.0042). P53 expression (P=0.023), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.009) were identified as independent factors affecting OS in patients with esophageal cancer via a Cox multivariate regression model analysis. A similar analysis also identified P53 expression (P=0.020), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.008) as independent prognostic factors influencing DFS in these patients. Binary logistic regression analysis demonstrated a correlation between P53 expression (P=0.012), TNM staging (P<0.001), tumor differentiation level (P=0.023) and P53/Cox-2 co-expression (P=0.021), and local recurrence or distant esophageal cancer metastasis. The results of the present study indicate that P53 and Cox-2 proteins may act synergistically in the development of esophageal cancer, and the assessment of P53/Cox-2 co-expression status in esophageal cancer biopsies may become an important diagnostic criterion to evaluate the prognosis of patients with esophageal cancer.
Url:
DOI: 10.3892/ol.2015.3624
PubMed: 26622818
PubMed Central: 4579898
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>The present study aimed to explore the importance of P53 and Cox-2 protein expression in esophageal cancer and assess their influence on prognosis. The expression of P53 and Cox-2 was assessed in esophageal cancer samples from 195 patients subjected to radical surgery at Changzhou First People's Hospital (Changzhou, China) between May 2010 and December 2011. Expression of P53 and Cox-2 proteins were detected in 60.5% (118/195) and 69.7% (136/195) of the samples, respectively, and were co-expressed in 43.1% (84/195) of the samples. A correlation was identified between P53 expression and overall survival (OS) (P=0.0351) as well as disease-free survival (DFS) (P=0.0307). In addition, the co-expression of P53 and Cox-2 also correlated with OS (P=0.0040) and DFS (P=0.0042). P53 expression (P=0.023), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.009) were identified as independent factors affecting OS in patients with esophageal cancer via a Cox multivariate regression model analysis. A similar analysis also identified P53 expression (P=0.020), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.008) as independent prognostic factors influencing DFS in these patients. Binary logistic regression analysis demonstrated a correlation between P53 expression (P=0.012), TNM staging (P<0.001), tumor differentiation level (P=0.023) and P53/Cox-2 co-expression (P=0.021), and local recurrence or distant esophageal cancer metastasis. The results of the present study indicate that P53 and Cox-2 proteins may act synergistically in the development of esophageal cancer, and the assessment of P53/Cox-2 co-expression status in esophageal cancer biopsies may become an important diagnostic criterion to evaluate the prognosis of patients with esophageal cancer.</p>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name>
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<name sortKey="Gu, Wen Dong" sort="Gu, Wen Dong" uniqKey="Gu W" first="Wen-Dong" last="Gu">Wen-Dong Gu</name>
<name sortKey="Huang, Jin" sort="Huang, Jin" uniqKey="Huang J" first="Jin" last="Huang">Jin Huang</name>
<name sortKey="Ning, Zhong Hua" sort="Ning, Zhong Hua" uniqKey="Ning Z" first="Zhong-Hua" last="Ning">Zhong-Hua Ning</name>
<name sortKey="Pei, Hong Lei" sort="Pei, Hong Lei" uniqKey="Pei H" first="Hong-Lei" last="Pei">Hong-Lei Pei</name>
<name sortKey="Shao, Ying Jie" sort="Shao, Ying Jie" uniqKey="Shao Y" first="Ying-Jie" last="Shao">Ying-Jie Shao</name>
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