Analysis of the correlation between P53 and Cox-2 expression and prognosis in esophageal cancer
Identifieur interne : 002151 ( Main/Merge ); précédent : 002150; suivant : 002152Analysis of the correlation between P53 and Cox-2 expression and prognosis in esophageal cancer
Auteurs : Jun Chen [République populaire de Chine] ; Fang Wu [République populaire de Chine] ; Hong-Lei Pei [République populaire de Chine] ; Wen-Dong Gu [République populaire de Chine] ; Zhong-Hua Ning [République populaire de Chine] ; Ying-Jie Shao [République populaire de Chine] ; Jin Huang [République populaire de Chine]Source :
- Oncology Letters [ 1792-1074 ] ; 2015.
Abstract
The present study aimed to explore the importance of P53 and Cox-2 protein expression in esophageal cancer and assess their influence on prognosis. The expression of P53 and Cox-2 was assessed in esophageal cancer samples from 195 patients subjected to radical surgery at Changzhou First People's Hospital (Changzhou, China) between May 2010 and December 2011. Expression of P53 and Cox-2 proteins were detected in 60.5% (118/195) and 69.7% (136/195) of the samples, respectively, and were co-expressed in 43.1% (84/195) of the samples. A correlation was identified between P53 expression and overall survival (OS) (P=0.0351) as well as disease-free survival (DFS) (P=0.0307). In addition, the co-expression of P53 and Cox-2 also correlated with OS (P=0.0040) and DFS (P=0.0042). P53 expression (P=0.023), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.009) were identified as independent factors affecting OS in patients with esophageal cancer via a Cox multivariate regression model analysis. A similar analysis also identified P53 expression (P=0.020), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.008) as independent prognostic factors influencing DFS in these patients. Binary logistic regression analysis demonstrated a correlation between P53 expression (P=0.012), TNM staging (P<0.001), tumor differentiation level (P=0.023) and P53/Cox-2 co-expression (P=0.021), and local recurrence or distant esophageal cancer metastasis. The results of the present study indicate that P53 and Cox-2 proteins may act synergistically in the development of esophageal cancer, and the assessment of P53/Cox-2 co-expression status in esophageal cancer biopsies may become an important diagnostic criterion to evaluate the prognosis of patients with esophageal cancer.
Url:
DOI: 10.3892/ol.2015.3624
PubMed: 26622818
PubMed Central: 4579898
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jin" sort="Huang, Jin" uniqKey="Huang J" first="Jin" last="Huang">Jin Huang</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-3624">Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26622818</idno><idno type="pmc">4579898</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579898</idno><idno type="RBID">PMC:4579898</idno><idno type="doi">10.3892/ol.2015.3624</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000384</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000384</idno><idno type="wicri:Area/Pmc/Curation">000384</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000384</idno><idno type="wicri:Area/Pmc/Checkpoint">001513</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001513</idno><idno type="wicri:Area/Ncbi/Merge">007B82</idno><idno type="wicri:Area/Ncbi/Curation">007B82</idno><idno type="wicri:Area/Ncbi/Checkpoint">007B82</idno><idno type="wicri:doubleKey">1792-1074:2015:Chen J:analysis:of:the</idno><idno type="wicri:Area/Main/Merge">002151</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Analysis of the correlation between P53 and Cox-2 expression and prognosis in esophageal cancer</title><author><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-3624">Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Fang" sort="Wu, Fang" uniqKey="Wu F" first="Fang" last="Wu">Fang Wu</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-0-0-3624">Department of Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author><author><name sortKey="Pei, Hong Lei" sort="Pei, Hong Lei" uniqKey="Pei H" first="Hong-Lei" last="Pei">Hong-Lei Pei</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-3624">Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author><author><name sortKey="Gu, Wen Dong" sort="Gu, Wen Dong" uniqKey="Gu W" first="Wen-Dong" last="Gu">Wen-Dong Gu</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-3624">Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author><author><name sortKey="Ning, Zhong Hua" sort="Ning, Zhong Hua" uniqKey="Ning Z" first="Zhong-Hua" last="Ning">Zhong-Hua Ning</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-3624">Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author><author><name sortKey="Shao, Ying Jie" sort="Shao, Ying Jie" uniqKey="Shao Y" first="Ying-Jie" last="Shao">Ying-Jie Shao</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-3624">Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jin" sort="Huang, Jin" uniqKey="Huang J" first="Jin" last="Huang">Jin Huang</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-3624">Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003</wicri:regionArea><wicri:noRegion>Jiangsu 213003</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncology Letters</title><idno type="ISSN">1792-1074</idno><idno type="eISSN">1792-1082</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The present study aimed to explore the importance of P53 and Cox-2 protein expression in esophageal cancer and assess their influence on prognosis. The expression of P53 and Cox-2 was assessed in esophageal cancer samples from 195 patients subjected to radical surgery at Changzhou First People's Hospital (Changzhou, China) between May 2010 and December 2011. Expression of P53 and Cox-2 proteins were detected in 60.5% (118/195) and 69.7% (136/195) of the samples, respectively, and were co-expressed in 43.1% (84/195) of the samples. A correlation was identified between P53 expression and overall survival (OS) (P=0.0351) as well as disease-free survival (DFS) (P=0.0307). In addition, the co-expression of P53 and Cox-2 also correlated with OS (P=0.0040) and DFS (P=0.0042). P53 expression (P=0.023), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.009) were identified as independent factors affecting OS in patients with esophageal cancer via a Cox multivariate regression model analysis. A similar analysis also identified P53 expression (P=0.020), TNM staging (P<0.001) and P53/Cox-2 co-expression (P=0.008) as independent prognostic factors influencing DFS in these patients. Binary logistic regression analysis demonstrated a correlation between P53 expression (P=0.012), TNM staging (P<0.001), tumor differentiation level (P=0.023) and P53/Cox-2 co-expression (P=0.021), and local recurrence or distant esophageal cancer metastasis. The results of the present study indicate that P53 and Cox-2 proteins may act synergistically in the development of esophageal cancer, and the assessment of P53/Cox-2 co-expression status in esophageal cancer biopsies may become an important diagnostic criterion to evaluate the prognosis of patients with esophageal cancer.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Huang, Jx" uniqKey="Huang J">JX Huang</name></author><author><name sortKey="Chen, Wc" uniqKey="Chen W">WC Chen</name></author><author><name sortKey="Lin, M" uniqKey="Lin M">M Lin</name></author><author><name sortKey="Zhang, Yl" uniqKey="Zhang Y">YL Zhang</name></author><author><name sortKey="Li, Fy" uniqKey="Li F">FY Li</name></author><author><name sortKey="Song, Zx" uniqKey="Song Z">ZX Song</name></author><author><name sortKey="Xiao, W" uniqKey="Xiao W">W Xiao</name></author><author><name sortKey="Chen, P" uniqKey="Chen P">P Chen</name></author><author><name 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uniqKey="Taniere P">P Tanière</name></author><author><name sortKey="Chariot, A" uniqKey="Chariot A">A Chariot</name></author><author><name sortKey="Scoazec, Jy" uniqKey="Scoazec J">JY Scoazec</name></author><author><name sortKey="De Moura Gallo, Cv" uniqKey="De Moura Gallo C">CV de Moura Gallo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Xing, D" uniqKey="Xing D">D Xing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, As" uniqKey="Cheng A">AS Cheng</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Lai, Pb" uniqKey="Lai P">PB Lai</name></author><author><name sortKey="Chan, Hl" uniqKey="Chan H">HL Chan</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Em" uniqKey="Choi E">EM Choi</name></author><author><name sortKey="Kim, Sr" uniqKey="Kim S">SR Kim</name></author><author><name sortKey="Lee, Ej" uniqKey="Lee E">EJ Lee</name></author><author><name sortKey="Han, Ja" uniqKey="Han J">JA Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, Xl" uniqKey="Ma X">XL Ma</name></author><author><name sortKey="Xs, G" uniqKey="Xs G">G XS</name></author><author><name sortKey="Sun, Hj" uniqKey="Sun H">HJ Sun</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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