An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Identifieur interne : 009794 ( Main/Exploration ); précédent : 009793; suivant : 009795An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Auteurs : Jeffrey T. Wigle [États-Unis, Canada] ; Natasha Harvey [États-Unis] ; Michael Detmar [États-Unis] ; Irina Lagutina [États-Unis] ; Gerard Grosveld [États-Unis] ; Michael D. Gunn [États-Unis] ; David G. Jackson [Royaume-Uni] ; Guillermo Oliver [États-Unis]Source :
- The EMBO Journal [ 0261-4189 ] ; 2002-04-01.
Abstract
The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In Prox1−/− embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild‐type embryos, those of Prox1‐null embryos did not co‐express any lymphatic markers such as VEGFR‐3, LYVE‐1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that Prox1 activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.
Url:
- https://api.istex.fr/document/430BFF725DBFA4AABFD1C302051944C214642EDE/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125938
DOI: 10.1093/emboj/21.7.1505
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001E74
- to stream Istex, to step Curation: 001E74
- to stream Istex, to step Checkpoint: 002737
- to stream Pmc, to step Corpus: 001752
- to stream Pmc, to step Curation: 001751
- to stream Pmc, to step Checkpoint: 003F78
- to stream Ncbi, to step Merge: 000913
- to stream Ncbi, to step Curation: 000913
- to stream Ncbi, to step Checkpoint: 000913
- to stream Main, to step Merge: 009B75
- to stream Main, to step Curation: 009794
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype</title>
<author><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
</author>
<author><name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
</author>
<author><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name>
</author>
<author><name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name>
</author>
<author><name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name>
</author>
<author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name>
</author>
<author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:430BFF725DBFA4AABFD1C302051944C214642EDE</idno>
<date when="2002" year="2002">2002</date>
<idno type="doi">10.1093/emboj/21.7.1505</idno>
<idno type="url">https://api.istex.fr/document/430BFF725DBFA4AABFD1C302051944C214642EDE/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001E74</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001E74</idno>
<idno type="wicri:Area/Istex/Curation">001E74</idno>
<idno type="wicri:Area/Istex/Checkpoint">002737</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002737</idno>
<idno type="wicri:doubleKey">0261-4189:2002:Wigle J:an:essential:role</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125938</idno>
<idno type="RBID">PMC:125938</idno>
<idno type="wicri:Area/Pmc/Corpus">001752</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001752</idno>
<idno type="wicri:Area/Pmc/Curation">001751</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001751</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003F78</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003F78</idno>
<idno type="wicri:Area/Ncbi/Merge">000913</idno>
<idno type="wicri:Area/Ncbi/Curation">000913</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000913</idno>
<idno type="wicri:doubleKey">0261-4189:2002:Wigle J:an:essential:role</idno>
<idno type="wicri:Area/Main/Merge">009B75</idno>
<idno type="wicri:Area/Main/Curation">009794</idno>
<idno type="wicri:Area/Main/Exploration">009794</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">An essential role for <hi rend="italic">Prox1</hi>
in the induction of the lymphatic endothelial cell phenotype</title>
<author><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, St Jude Children's Research Hospital, 38105, Memphis, TN</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg</wicri:regionArea>
<wicri:noRegion>Winnipeg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, St Jude Children's Research Hospital, TN, 38105, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, MA, 02114, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, St Jude Children's Research Hospital, TN, 38105, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, St Jude Children's Research Hospital, TN, 38105, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cardiology, Department of Medicine, Duke University Medical Center, NC, 27710, Durham</wicri:regionArea>
<wicri:noRegion>Durham</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, Headington</wicri:regionArea>
<wicri:noRegion>Headington</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
<affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, St Jude Children's Research Hospital, TN, 38105, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The EMBO Journal</title>
<title level="j" type="alt">THE EMBO JOURNAL</title>
<idno type="ISSN">0261-4189</idno>
<idno type="eISSN">1460-2075</idno>
<imprint><biblScope unit="vol">21</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="1505">1505</biblScope>
<biblScope unit="page" to="1513">1513</biblScope>
<biblScope unit="page-count">9</biblScope>
<publisher>John Wiley & Sons, Ltd</publisher>
<pubPlace>Chichester, UK</pubPlace>
<date type="published" when="2002-04-01">2002-04-01</date>
</imprint>
<idno type="ISSN">0261-4189</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0261-4189</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In Prox1−/− embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild‐type embryos, those of Prox1‐null embryos did not co‐express any lymphatic markers such as VEGFR‐3, LYVE‐1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that Prox1 activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Tennessee</li>
</region>
<settlement><li>Boston</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
</region>
<name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name>
<name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name>
<name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name>
<name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name>
<name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
</country>
<country name="Canada"><noRegion><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
</noRegion>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009794 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 009794 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:430BFF725DBFA4AABFD1C302051944C214642EDE |texte= An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype }}
This area was generated with Dilib version V0.6.31. |