LymphedemaV1, Pmc, Checkpoint, bibRecord, 003F78

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

Identifieur interne : 003F78 ( Pmc/Checkpoint ); précédent : 003F77; suivant : 003F79

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

Auteurs : Jeffrey T. Wigle [États-Unis, Canada] ; Natasha Harvey [États-Unis] ; Michael Detmar [États-Unis] ; Irina Lagutina [États-Unis] ; Gerard Grosveld [États-Unis] ; Michael D. Gunn [États-Unis] ; David G. Jackson [Royaume-Uni] ; Guillermo Oliver [États-Unis]

Source :

The EMBO Journal [ 0261-4189 ] ; 2002.

RBID : PMC:125938

Abstract

The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In Prox1^–^/– embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild-type embryos, those of Prox1-null embryos did not co-express any lymphatic markers such as VEGFR-3, LYVE-1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that Prox1 activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125938

DOI: 10.1093/emboj/21.7.1505
PubMed: 11927535
PubMed Central: 125938

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 001752
to stream Pmc, to step Curation: 001751

Links to Exploration step

PMC:125938

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An essential role for <italic>Prox1</italic>
 in the induction of the lymphatic endothelial cell phenotype</title>
<author><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="N0x99ab270.0x8bcf128">Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg</wicri:regionArea>
<wicri:noRegion>Winnipeg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="N0x99ab270.0x8bcf128">Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710</wicri:regionArea>
<wicri:noRegion>NC 27710</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name>
<affiliation wicri:level="1"><nlm:aff id="N0x99ab270.0x8bcf128">MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS</wicri:regionArea>
<wicri:noRegion>Oxford OX3 9DS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Corresponding author e-mail: guillermo.oliver@stjude.org</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">11927535</idno>
<idno type="pmc">125938</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125938</idno>
<idno type="RBID">PMC:125938</idno>
<idno type="doi">10.1093/emboj/21.7.1505</idno>
<date when="2002">2002</date>
<idno type="wicri:Area/Pmc/Corpus">001752</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001752</idno>
<idno type="wicri:Area/Pmc/Curation">001751</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001751</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003F78</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003F78</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An essential role for <italic>Prox1</italic>
 in the induction of the lymphatic endothelial cell phenotype</title>
<author><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="N0x99ab270.0x8bcf128">Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg</wicri:regionArea>
<wicri:noRegion>Winnipeg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="N0x99ab270.0x8bcf128">Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710</wicri:regionArea>
<wicri:noRegion>NC 27710</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name>
<affiliation wicri:level="1"><nlm:aff id="N0x99ab270.0x8bcf128">MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS</wicri:regionArea>
<wicri:noRegion>Oxford OX3 9DS</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
<affiliation wicri:level="2"><nlm:aff id="N0x99ab270.0x8bcf128">Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Genetics, St Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="N0x99ab270.0x8bcf128">Corresponding author e-mail: guillermo.oliver@stjude.org</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The EMBO Journal</title>
<idno type="ISSN">0261-4189</idno>
<idno type="eISSN">1460-2075</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene <italic>Prox1</italic>
 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In <italic>Prox1</italic>
<sup>–</sup>
<sup>/–</sup>
 embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild-type embryos, those of <italic>Prox1</italic>
-null embryos did not co-express any lymphatic markers such as VEGFR-3, LYVE-1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that <italic>Prox1</italic>
 activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id>
<journal-title>The EMBO Journal</journal-title>
<issn pub-type="ppub">0261-4189</issn>
<issn pub-type="epub">1460-2075</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
<publisher-loc>Oxford, UK</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">11927535</article-id>
<article-id pub-id-type="pmc">125938</article-id>
<article-id pub-id-type="publisher-id">cdf152</article-id>
<article-id pub-id-type="doi">10.1093/emboj/21.7.1505</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>An essential role for <italic>Prox1</italic>
 in the induction of the lymphatic endothelial cell phenotype</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Wigle</surname>
<given-names>Jeffrey T.</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harvey</surname>
<given-names>Natasha</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Detmar</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lagutina</surname>
<given-names>Irina</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grosveld</surname>
<given-names>Gerard</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gunn</surname>
<given-names>Michael D.</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jackson</surname>
<given-names>David G.</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oliver</surname>
<given-names>Guillermo</given-names>
</name>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">1</xref>
<xref ref-type="aff" rid="N0x99ab270.0x8bcf128">6</xref>
</contrib>
</contrib-group>
<aff id="N0x99ab270.0x8bcf128"><label>1</label>
Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105,<label>3</label>
Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114,<label>4</label>
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA and<label>5</label>
MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK<label>2</label>
Present address: Division of Stroke and Vascular Disease and Department of Biochemistry and Medical Genetics, St Boniface General Hospital Research Centre, Winnipeg, Canada<label>6</label>
Corresponding author e-mail: guillermo.oliver@stjude.org</aff>
<pub-date pub-type="ppub"><day>2</day>
<month>4</month>
<year>2002</year>
</pub-date>
<volume>21</volume>
<issue>7</issue>
<fpage>1505</fpage>
<lpage>1513</lpage>
<ext-link ext-link-type="uri" xlink:href="http://www.emboj.oupjournals.org/content/vol21/issue7/"></ext-link>
<history><date date-type="received"><day>17</day>
<month>12</month>
<year>2001</year>
</date>
<date date-type="rev-recd"><day>22</day>
<month>1</month>
<year>2002</year>
</date>
<date date-type="accepted"><day>31</day>
<month>1</month>
<year>2002</year>
</date>
</history>
<copyright-statement>Copyright © 2002 European Molecular Biology Organization</copyright-statement>
<copyright-year>2002</copyright-year>
<abstract><p>The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene <italic>Prox1</italic>
 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In <italic>Prox1</italic>
<sup>–</sup>
<sup>/–</sup>
 embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild-type embryos, those of <italic>Prox1</italic>
-null embryos did not co-express any lymphatic markers such as VEGFR-3, LYVE-1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that <italic>Prox1</italic>
 activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.</p>
</abstract>
<kwd-group><kwd>lymphangiogenesis/lymphatic endothelial cells/<italic>LYVE-1/Prox1</italic>
/<italic>SLC</italic>
/<italic>VEGFR-3</italic>
</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Canada</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Tennessee</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
</region>
<name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<name sortKey="Grosveld, Gerard" sort="Grosveld, Gerard" uniqKey="Grosveld G" first="Gerard" last="Grosveld">Gerard Grosveld</name>
<name sortKey="Gunn, Michael D" sort="Gunn, Michael D" uniqKey="Gunn M" first="Michael D." last="Gunn">Michael D. Gunn</name>
<name sortKey="Harvey, Natasha" sort="Harvey, Natasha" uniqKey="Harvey N" first="Natasha" last="Harvey">Natasha Harvey</name>
<name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name>
<name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
</country>
<country name="Canada"><noRegion><name sortKey="Wigle, Jeffrey T" sort="Wigle, Jeffrey T" uniqKey="Wigle J" first="Jeffrey T." last="Wigle">Jeffrey T. Wigle</name>
</noRegion>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003F78 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 003F78 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Pmc
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:125938
   |texte=   An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i   -Sk "pubmed:11927535" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki