An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Identifieur interne : 000913 ( Ncbi/Curation ); précédent : 000912; suivant : 000914An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Auteurs : Jeffrey T. Wigle [États-Unis, Canada] ; Natasha Harvey [États-Unis] ; Michael Detmar [États-Unis] ; Irina Lagutina [États-Unis] ; Gerard Grosveld [États-Unis] ; Michael D. Gunn [États-Unis] ; David G. Jackson [Royaume-Uni] ; Guillermo Oliver [États-Unis]Source :
- The EMBO Journal [ 0261-4189 ] ; 2002.
Abstract
The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene
Url:
DOI: 10.1093/emboj/21.7.1505
PubMed: 11927535
PubMed Central: 125938
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PMC:125938Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An essential role for <italic>Prox1</italic>
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<author><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
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<front><div type="abstract" xml:lang="en"><p>The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene <italic>Prox1</italic>
is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In <italic>Prox1</italic>
<sup>–</sup>
<sup>/–</sup>
embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothelial cells that bud off in E11.5 wild-type embryos, those of <italic>Prox1</italic>
-null embryos did not co-express any lymphatic markers such as VEGFR-3, LYVE-1 or SLC. Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34. These results suggest that <italic>Prox1</italic>
activity is required for both maintenance of the budding of the venous endothelial cells and differentiation toward the lymphatic phenotype. On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.</p>
</div>
</front>
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