Brugia malayi: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model
Identifieur interne : 007367 ( Main/Exploration ); précédent : 007366; suivant : 007368Brugia malayi: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model
Auteurs : Sivasakthivel Thirugnanam [Inde] ; Pandurangan Pandiaraja [Inde] ; Kalyanasundaram Ramaswamy [États-Unis] ; Vadivel Murugan [Inde] ; Munirathinam Gnanasekar [États-Unis] ; Krithika Nandakumar [Inde] ; Maryada Venkata Rami Reddy [Inde] ; Perumal Kaliraj [Inde]Source :
- Experimental parasitology [ 0014-4894 ] ; 2007.
Descripteurs français
- KwdFr :
- ADN des helminthes (immunologie), Activation des lymphocytes, Animaux, Anticorps antihelminthe (biosynthèse), Anticorps antihelminthe (sang), Antigènes d'helminthe (génétique), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Chambres de culture à diffusion, Cytokines (biosynthèse), Cytokines (génétique), Filariose lymphatique (), Gerbillinae, Immunisation (), Immunité cellulaire, Lymphocytes auxiliaires Th2 (immunologie), Modèles animaux de maladie humaine, Mâle, Protéines d'helminthes (génétique), Protéines d'helminthes (immunologie), Protéines recombinantes (génétique), Protéines recombinantes (immunologie), Vaccins (immunologie), Vaccins synthétiques (immunologie), Vaccins à ADN (immunologie).
- MESH :
- biosynthèse : Anticorps antihelminthe, Cytokines.
- génétique : Antigènes d'helminthe, Cytokines, Protéines d'helminthes, Protéines recombinantes.
- immunologie : ADN des helminthes, Antigènes d'helminthe, Brugia malayi, Lymphocytes auxiliaires Th2, Protéines d'helminthes, Protéines recombinantes, Vaccins, Vaccins synthétiques, Vaccins à ADN.
- sang : Anticorps antihelminthe.
- Activation des lymphocytes, Animaux, Chambres de culture à diffusion, Filariose lymphatique, Gerbillinae, Immunisation, Immunité cellulaire, Modèles animaux de maladie humaine, Mâle.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Antibodies, Helminth (blood), Antigens, Helminth (genetics), Antigens, Helminth (immunology), Brugia malayi (immunology), Cytokines (biosynthesis), Cytokines (genetics), DNA, Helminth (immunology), Diffusion Chambers, Culture, Disease Models, Animal, Elephantiasis, Filarial (prevention & control), Gerbillinae, Helminth Proteins (genetics), Helminth Proteins (immunology), Immunity, Cellular, Immunization (methods), Lymphocyte Activation, Male, Recombinant Proteins (genetics), Recombinant Proteins (immunology), Th2 Cells (immunology), Vaccines (immunology), Vaccines, DNA (immunology), Vaccines, Synthetic (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth, Cytokines.
- chemical , blood : Antibodies, Helminth.
- chemical , genetics : Antigens, Helminth, Cytokines, Helminth Proteins, Recombinant Proteins.
- chemical , immunology : Antigens, Helminth, DNA, Helminth, Helminth Proteins, Recombinant Proteins, Vaccines, Vaccines, DNA, Vaccines, Synthetic.
- immunology : Brugia malayi, Th2 Cells.
- methods : Immunization.
- prevention & control : Elephantiasis, Filarial.
- Animals, Diffusion Chambers, Culture, Disease Models, Animal, Gerbillinae, Immunity, Cellular, Lymphocyte Activation, Male.
Abstract
Immunization of jirds with Bm-alt-2 elicited partial protection against challenge infection with the filarial parasite
Url:
DOI: 10.1016/j.exppara.2007.02.017
PubMed: 17442307
PubMed Central: 2763209
Affiliations:
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Le document en format XML
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: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model</title>
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<author><name sortKey="Murugan, Vadivel" sort="Murugan, Vadivel" uniqKey="Murugan V" first="Vadivel" last="Murugan">Vadivel Murugan</name>
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<author><name sortKey="Gnanasekar, Munirathinam" sort="Gnanasekar, Munirathinam" uniqKey="Gnanasekar M" first="Munirathinam" last="Gnanasekar">Munirathinam Gnanasekar</name>
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<author><name sortKey="Nandakumar, Krithika" sort="Nandakumar, Krithika" uniqKey="Nandakumar K" first="Krithika" last="Nandakumar">Krithika Nandakumar</name>
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<series><title level="j">Experimental parasitology</title>
<idno type="ISSN">0014-4894</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Helminth (biosynthesis)</term>
<term>Antibodies, Helminth (blood)</term>
<term>Antigens, Helminth (genetics)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Brugia malayi (immunology)</term>
<term>Cytokines (biosynthesis)</term>
<term>Cytokines (genetics)</term>
<term>DNA, Helminth (immunology)</term>
<term>Diffusion Chambers, Culture</term>
<term>Disease Models, Animal</term>
<term>Elephantiasis, Filarial (prevention & control)</term>
<term>Gerbillinae</term>
<term>Helminth Proteins (genetics)</term>
<term>Helminth Proteins (immunology)</term>
<term>Immunity, Cellular</term>
<term>Immunization (methods)</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Recombinant Proteins (genetics)</term>
<term>Recombinant Proteins (immunology)</term>
<term>Th2 Cells (immunology)</term>
<term>Vaccines (immunology)</term>
<term>Vaccines, DNA (immunology)</term>
<term>Vaccines, Synthetic (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN des helminthes (immunologie)</term>
<term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Anticorps antihelminthe (biosynthèse)</term>
<term>Anticorps antihelminthe (sang)</term>
<term>Antigènes d'helminthe (génétique)</term>
<term>Antigènes d'helminthe (immunologie)</term>
<term>Brugia malayi (immunologie)</term>
<term>Chambres de culture à diffusion</term>
<term>Cytokines (biosynthèse)</term>
<term>Cytokines (génétique)</term>
<term>Filariose lymphatique ()</term>
<term>Gerbillinae</term>
<term>Immunisation ()</term>
<term>Immunité cellulaire</term>
<term>Lymphocytes auxiliaires Th2 (immunologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Protéines d'helminthes (génétique)</term>
<term>Protéines d'helminthes (immunologie)</term>
<term>Protéines recombinantes (génétique)</term>
<term>Protéines recombinantes (immunologie)</term>
<term>Vaccins (immunologie)</term>
<term>Vaccins synthétiques (immunologie)</term>
<term>Vaccins à ADN (immunologie)</term>
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<term>Cytokines</term>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Helminth</term>
<term>Cytokines</term>
<term>Helminth Proteins</term>
<term>Recombinant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
<term>DNA, Helminth</term>
<term>Helminth Proteins</term>
<term>Recombinant Proteins</term>
<term>Vaccines</term>
<term>Vaccines, DNA</term>
<term>Vaccines, Synthetic</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term>
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes d'helminthe</term>
<term>Cytokines</term>
<term>Protéines d'helminthes</term>
<term>Protéines recombinantes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>ADN des helminthes</term>
<term>Antigènes d'helminthe</term>
<term>Brugia malayi</term>
<term>Lymphocytes auxiliaires Th2</term>
<term>Protéines d'helminthes</term>
<term>Protéines recombinantes</term>
<term>Vaccins</term>
<term>Vaccins synthétiques</term>
<term>Vaccins à ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Diffusion Chambers, Culture</term>
<term>Disease Models, Animal</term>
<term>Gerbillinae</term>
<term>Immunity, Cellular</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Chambres de culture à diffusion</term>
<term>Filariose lymphatique</term>
<term>Gerbillinae</term>
<term>Immunisation</term>
<term>Immunité cellulaire</term>
<term>Modèles animaux de maladie humaine</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Immunization of jirds with Bm-alt-2 elicited partial protection against challenge infection with the filarial parasite <italic>Brugia malayi</italic>
. In this study, we initially compared the protective immune responses elicited following immunization with recombinant Bm-ALT-2 protein regimen and Bm-alt-2 DNA regimen. These studies showed that protein vaccination conferred approximately 75% protection compared to DNA vaccination that conferred only 57% protection. Analysis of the protective immune responses showed that the protein immunization promoted a Th2-biased response with an increase in IL-4, IL-5 and IgG1 responses, whereas, the DNA vaccine promoted a Th1-biased response with profound IFN-γ and IgG2a responses. Since protein vaccination gave better results than DNA vaccination, we then wanted to evaluate whether a prime-boost vaccination that combined DNA prime and protein boost will significantly increase the protective responses induced by the protein vaccine. Our results suggest that prime-boost vaccination had no added advantage and was comparatively less effective (64% protection) than the Bm-ALT-2 protein alone vaccination. Prime boost vaccination generated mixed Th1/Th2 responses with a slightly diminished Th2 responses compared to protein vaccination. Thus, our results suggest that Bm-ALT-2 protein vaccination regimen may be slightly better than prime-boost vaccine regimen and the mechanism of protection appears to be largely mediated by a Th2-biased response.</p>
</div>
</front>
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<name sortKey="Reddy, Maryada Venkata Rami" sort="Reddy, Maryada Venkata Rami" uniqKey="Reddy M" first="Maryada Venkata Rami" last="Reddy">Maryada Venkata Rami Reddy</name>
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