Acquired lymphedema: an urgent need for adequate animal models.
Identifieur interne : 006C35 ( Main/Exploration ); précédent : 006C34; suivant : 006C36Acquired lymphedema: an urgent need for adequate animal models.
Auteurs : Catarina Hadamitzky [Allemagne] ; Reinhard PabstSource :
- Cancer research [ 1538-7445 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Lymphoedème.
- étiologie : Lymphoedème.
- Animaux, Chiens, Humains, Lagomorpha, Modèles animaux de maladie humaine, Rodentia.
English descriptors
- KwdEn :
- MESH :
- etiology : Lymphedema.
- pathology : Lymphedema.
- Animals, Disease Models, Animal, Dogs, Humans, Lagomorpha, Rodentia.
Abstract
In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications.
DOI: 10.1158/0008-5472.CAN-07-2454
PubMed: 18199525
Affiliations:
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Le document en format XML
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Hadamitzky.Catarina@MH-Hannover.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Functional and Applied Anatomy, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Pabst, Reinhard" sort="Pabst, Reinhard" uniqKey="Pabst R" first="Reinhard" last="Pabst">Reinhard Pabst</name></author></analytic><series><title level="j">Cancer research</title><idno type="eISSN">1538-7445</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Dogs</term><term>Humans</term><term>Lagomorpha</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Rodentia</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Humains</term><term>Lagomorpha</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (étiologie)</term><term>Modèles animaux de maladie humaine</term><term>Rodentia</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Dogs</term><term>Humans</term><term>Lagomorpha</term><term>Rodentia</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Humains</term><term>Lagomorpha</term><term>Modèles animaux de maladie humaine</term><term>Rodentia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Hanovre</li></settlement></list><tree><noCountry><name sortKey="Pabst, Reinhard" sort="Pabst, Reinhard" uniqKey="Pabst R" first="Reinhard" last="Pabst">Reinhard Pabst</name></noCountry><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Hadamitzky, Catarina" sort="Hadamitzky, Catarina" uniqKey="Hadamitzky C" first="Catarina" last="Hadamitzky">Catarina Hadamitzky</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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