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Acquired lymphedema: an urgent need for adequate animal models.

Identifieur interne : 003413 ( PubMed/Corpus ); précédent : 003412; suivant : 003414

Acquired lymphedema: an urgent need for adequate animal models.

Auteurs : Catarina Hadamitzky ; Reinhard Pabst

Source :

RBID : pubmed:18199525

English descriptors

Abstract

In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications.

DOI: 10.1158/0008-5472.CAN-07-2454
PubMed: 18199525

Links to Exploration step

pubmed:18199525

Le document en format XML

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