Acquired lymphedema: an urgent need for adequate animal models.
Identifieur interne : 003413 ( PubMed/Curation ); précédent : 003412; suivant : 003414Acquired lymphedema: an urgent need for adequate animal models.
Auteurs : Catarina Hadamitzky [Allemagne] ; Reinhard PabstSource :
- Cancer research [ 1538-7445 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Lymphoedème.
- étiologie : Lymphoedème.
- Animaux, Chiens, Humains, Lagomorpha, Modèles animaux de maladie humaine, Rodentia.
English descriptors
- KwdEn :
- MESH :
- etiology : Lymphedema.
- pathology : Lymphedema.
- Animals, Disease Models, Animal, Dogs, Humans, Lagomorpha, Rodentia.
Abstract
In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications.
DOI: 10.1158/0008-5472.CAN-07-2454
PubMed: 18199525
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pubmed:18199525Le document en format XML
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<wicri:regionArea>Department of Functional and Applied Anatomy, Hannover Medical School, Hannover</wicri:regionArea>
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<term>Lymphedema (etiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
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<term>Rodentia</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term>
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<front><div type="abstract" xml:lang="en">In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications.</div>
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<Abstract><AbstractText>In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications.</AbstractText>
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