Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
Identifieur interne : 005739 ( Main/Exploration ); précédent : 005738; suivant : 005740Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
Auteurs : Xiaoxiao He [États-Unis, République populaire de Chine] ; Jinhao Gao [États-Unis, République populaire de Chine] ; Sanjiv Sam Gambhir [États-Unis] ; Zhen Cheng [États-Unis]Source :
- Trends in molecular medicine [ 1471-4914 ] ; 2010.
Abstract
Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.
Url:
DOI: 10.1016/j.molmed.2010.08.006
PubMed: 20870460
PubMed Central: 2994979
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002798
- to stream Pmc, to step Curation: 002797
- to stream Pmc, to step Checkpoint: 003310
- to stream Ncbi, to step Merge: 003E33
- to stream Ncbi, to step Curation: 003E33
- to stream Ncbi, to step Checkpoint: 003E33
- to stream Main, to step Merge: 005788
- to stream Main, to step Curation: 005739
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges</title>
<author><name sortKey="He, Xiaoxiao" sort="He, Xiaoxiao" uniqKey="He X" first="Xiaoxiao" last="He">Xiaoxiao He</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082</wicri:regionArea>
<wicri:noRegion>Changsha 410082</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Jinhao" sort="Gao, Jinhao" uniqKey="Gao J" first="Jinhao" last="Gao">Jinhao Gao</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005</wicri:regionArea>
<wicri:noRegion>Xiamen 361005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gambhir, Sanjiv Sam" sort="Gambhir, Sanjiv Sam" uniqKey="Gambhir S" first="Sanjiv Sam" last="Gambhir">Sanjiv Sam Gambhir</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Zhen" sort="Cheng, Zhen" uniqKey="Cheng Z" first="Zhen" last="Cheng">Zhen Cheng</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20870460</idno>
<idno type="pmc">2994979</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994979</idno>
<idno type="RBID">PMC:2994979</idno>
<idno type="doi">10.1016/j.molmed.2010.08.006</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">002798</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002798</idno>
<idno type="wicri:Area/Pmc/Curation">002797</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002797</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003310</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003310</idno>
<idno type="wicri:Area/Ncbi/Merge">003E33</idno>
<idno type="wicri:Area/Ncbi/Curation">003E33</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003E33</idno>
<idno type="wicri:doubleKey">1471-4914:2010:He X:near:infrared:fluorescent</idno>
<idno type="wicri:Area/Main/Merge">005788</idno>
<idno type="wicri:Area/Main/Curation">005739</idno>
<idno type="wicri:Area/Main/Exploration">005739</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges</title>
<author><name sortKey="He, Xiaoxiao" sort="He, Xiaoxiao" uniqKey="He X" first="Xiaoxiao" last="He">Xiaoxiao He</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082</wicri:regionArea>
<wicri:noRegion>Changsha 410082</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Jinhao" sort="Gao, Jinhao" uniqKey="Gao J" first="Jinhao" last="Gao">Jinhao Gao</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005</wicri:regionArea>
<wicri:noRegion>Xiamen 361005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gambhir, Sanjiv Sam" sort="Gambhir, Sanjiv Sam" uniqKey="Gambhir S" first="Sanjiv Sam" last="Gambhir">Sanjiv Sam Gambhir</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Zhen" sort="Cheng, Zhen" uniqKey="Cheng Z" first="Zhen" last="Cheng">Zhen Cheng</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea>
<wicri:noRegion>California 94305</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Trends in molecular medicine</title>
<idno type="ISSN">1471-4914</idno>
<idno type="eISSN">1471-499X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="He, Xiaoxiao" sort="He, Xiaoxiao" uniqKey="He X" first="Xiaoxiao" last="He">Xiaoxiao He</name>
</noRegion>
<name sortKey="Cheng, Zhen" sort="Cheng, Zhen" uniqKey="Cheng Z" first="Zhen" last="Cheng">Zhen Cheng</name>
<name sortKey="Gambhir, Sanjiv Sam" sort="Gambhir, Sanjiv Sam" uniqKey="Gambhir S" first="Sanjiv Sam" last="Gambhir">Sanjiv Sam Gambhir</name>
<name sortKey="Gambhir, Sanjiv Sam" sort="Gambhir, Sanjiv Sam" uniqKey="Gambhir S" first="Sanjiv Sam" last="Gambhir">Sanjiv Sam Gambhir</name>
<name sortKey="Gao, Jinhao" sort="Gao, Jinhao" uniqKey="Gao J" first="Jinhao" last="Gao">Jinhao Gao</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="He, Xiaoxiao" sort="He, Xiaoxiao" uniqKey="He X" first="Xiaoxiao" last="He">Xiaoxiao He</name>
</noRegion>
<name sortKey="Gao, Jinhao" sort="Gao, Jinhao" uniqKey="Gao J" first="Jinhao" last="Gao">Jinhao Gao</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005739 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005739 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2994979 |texte= Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20870460" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |