Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
Identifieur interne : 003E33 ( Ncbi/Merge ); précédent : 003E32; suivant : 003E34Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
Auteurs : Xiaoxiao He [États-Unis, République populaire de Chine] ; Jinhao Gao [États-Unis, République populaire de Chine] ; Sanjiv Sam Gambhir [États-Unis] ; Zhen Cheng [États-Unis]Source :
- Trends in molecular medicine [ 1471-4914 ] ; 2010.
Abstract
Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.
Url:
DOI: 10.1016/j.molmed.2010.08.006
PubMed: 20870460
PubMed Central: 2994979
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005</wicri:regionArea><wicri:noRegion>Xiamen 361005</wicri:noRegion></affiliation></author><author><name sortKey="Gambhir, Sanjiv Sam" sort="Gambhir, Sanjiv Sam" uniqKey="Gambhir S" first="Sanjiv Sam" last="Gambhir">Sanjiv Sam Gambhir</name><affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Zhen" sort="Cheng, Zhen" uniqKey="Cheng Z" first="Zhen" last="Cheng">Zhen Cheng</name><affiliation wicri:level="1"><nlm:aff id="A1">Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trends in molecular medicine</title><idno type="ISSN">1471-4914</idno><idno type="eISSN">1471-499X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100966035</journal-id><journal-id journal-id-type="pubmed-jr-id">22040</journal-id><journal-id journal-id-type="nlm-ta">Trends Mol Med</journal-id><journal-title>Trends in molecular medicine</journal-title><issn pub-type="ppub">1471-4914</issn><issn pub-type="epub">1471-499X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20870460</article-id><article-id pub-id-type="pmc">2994979</article-id><article-id pub-id-type="doi">10.1016/j.molmed.2010.08.006</article-id><article-id pub-id-type="manuscript">NIHMS234433</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>He</surname><given-names>Xiaoxiao</given-names></name><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Jinhao</given-names></name><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gambhir</surname><given-names>Sanjiv Sam</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Zhen</given-names></name><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</aff><aff id="A2"><label>2</label>State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082, P.R. China</aff><aff id="A3"><label>3</label>Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China</aff><aff id="A4"><label>4</label>Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305, USA</aff><author-notes><corresp id="cor1"><label>*</label> Corresponding Author: Zhen Cheng, PhD, Assistant Professor, Molecular Imaging Program at Stanford, Department of Radiology, 1201 Welch Road, Lucas Center, P020A, Stanford University, Stanford, CA, 94305-5484, Phone: 650-723-7866, Fax: 650-736-7925, <email>zcheng@stanford.edu</email></corresp><fn id="FN1" fn-type="equal"><label>†</label><p id="P1">equal contribution</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>9</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>1</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2011</year></pub-date><volume>16</volume><issue>12</issue><fpage>574</fpage><lpage>583</lpage><permissions><copyright-statement>© 2010 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P2">Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.</p></abstract><kwd-group><kwd>NIRF nanoprobes</kwd><kwd>molecular imaging</kwd><kwd>clinical translation</kwd><kwd>QDs</kwd><kwd>nanotubes</kwd></kwd-group><contract-num rid="CA1">U54 CA119367-05
||CA</contract-num><contract-num rid="CA1">R21 CA121842-03
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||CA</contract-num><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="He, Xiaoxiao" sort="He, Xiaoxiao" uniqKey="He X" first="Xiaoxiao" last="He">Xiaoxiao He</name></noRegion><name sortKey="Cheng, Zhen" sort="Cheng, Zhen" uniqKey="Cheng Z" first="Zhen" last="Cheng">Zhen Cheng</name><name sortKey="Gambhir, Sanjiv Sam" sort="Gambhir, Sanjiv Sam" uniqKey="Gambhir S" first="Sanjiv Sam" last="Gambhir">Sanjiv Sam Gambhir</name><name sortKey="Gambhir, Sanjiv Sam" sort="Gambhir, Sanjiv Sam" uniqKey="Gambhir S" first="Sanjiv Sam" last="Gambhir">Sanjiv Sam Gambhir</name><name sortKey="Gao, Jinhao" sort="Gao, Jinhao" uniqKey="Gao J" first="Jinhao" last="Gao">Jinhao Gao</name></country><country name="République populaire de Chine"><noRegion><name sortKey="He, Xiaoxiao" sort="He, Xiaoxiao" uniqKey="He X" first="Xiaoxiao" last="He">Xiaoxiao He</name></noRegion><name sortKey="Gao, Jinhao" sort="Gao, Jinhao" uniqKey="Gao J" first="Jinhao" last="Gao">Jinhao Gao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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