Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
Identifieur interne : 002798 ( Pmc/Corpus ); précédent : 002797; suivant : 002799Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
Auteurs : Xiaoxiao He ; Jinhao Gao ; Sanjiv Sam Gambhir ; Zhen ChengSource :
- Trends in molecular medicine [ 1471-4914 ] ; 2010.
Abstract
Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.
Url:
DOI: 10.1016/j.molmed.2010.08.006
PubMed: 20870460
PubMed Central: 2994979
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PMC:2994979Le document en format XML
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<affiliation><nlm:aff id="A2">State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082, P.R. China</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="P2">Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.</p>
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<journal-id journal-id-type="pubmed-jr-id">22040</journal-id>
<journal-id journal-id-type="nlm-ta">Trends Mol Med</journal-id>
<journal-title>Trends in molecular medicine</journal-title>
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<title-group><article-title>Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>He</surname>
<given-names>Xiaoxiao</given-names>
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<xref ref-type="author-notes" rid="FN1">†</xref>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Jinhao</given-names>
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<xref ref-type="author-notes" rid="FN1">†</xref>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
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<contrib contrib-type="author"><name><surname>Gambhir</surname>
<given-names>Sanjiv Sam</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
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<contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Zhen</given-names>
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<aff id="A1"><label>1</label>
Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94305, USA</aff>
<aff id="A2"><label>2</label>
State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Biology, Hunan University, Changsha 410082, P.R. China</aff>
<aff id="A3"><label>3</label>
Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China</aff>
<aff id="A4"><label>4</label>
Departments of Radiology and Bioengineering, Stanford University, Stanford, California 94305, USA</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding Author: Zhen Cheng, PhD, Assistant Professor, Molecular Imaging Program at Stanford, Department of Radiology, 1201 Welch Road, Lucas Center, P020A, Stanford University, Stanford, CA, 94305-5484, Phone: 650-723-7866, Fax: 650-736-7925, <email>zcheng@stanford.edu</email>
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<fn id="FN1" fn-type="equal"><label>†</label>
<p id="P1">equal contribution</p>
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<pub-date pub-type="nihms-submitted"><day>9</day>
<month>9</month>
<year>2010</year>
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<year>2010</year>
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<year>2010</year>
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<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2011</year>
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<volume>16</volume>
<issue>12</issue>
<fpage>574</fpage>
<lpage>583</lpage>
<permissions><copyright-statement>© 2010 Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><p id="P2">Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will likely be realized through persistent interdisciplinary amalgamation of diverse research fields.</p>
</abstract>
<kwd-group><kwd>NIRF nanoprobes</kwd>
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<kwd>clinical translation</kwd>
<kwd>QDs</kwd>
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