A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial
Identifieur interne : 005128 ( Main/Exploration ); précédent : 005127; suivant : 005129A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial
Auteurs : Roger T. Anderson ; Gretchen G. Kimmick ; Thomas P. Mccoy ; Judith Hopkins ; Edward Levine ; Gary Miller ; Paul Ribisl ; Shannon L. MihalkoSource :
- Journal of cancer survivorship : research and practice [ 1932-2259 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Complications postopératoires, Exercice physique, Femelle, Humains, Lymphoedème (), Mastectomie, Méthode en simple aveugle, Observance thérapeutique, Pronostic, Qualité de vie, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Techniques de physiothérapie, Tumeurs du sein (), Tumeurs du sein (rééducation et réadaptation), Éducation du patient comme sujet, Études de cohortes, Études de suivi.
- MESH :
- rééducation et réadaptation : Tumeurs du sein.
- Adulte, Adulte d'âge moyen, Complications postopératoires, Exercice physique, Femelle, Humains, Lymphoedème, Mastectomie, Méthode en simple aveugle, Observance thérapeutique, Pronostic, Qualité de vie, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Techniques de physiothérapie, Tumeurs du sein, Éducation du patient comme sujet, Études de cohortes, Études de suivi.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Breast Neoplasms (rehabilitation), Breast Neoplasms (surgery), Cohort Studies, Exercise, Female, Follow-Up Studies, Humans, Lymphedema (prevention & control), Mastectomy, Middle Aged, Neoplasm Staging, Patient Compliance, Patient Education as Topic, Physical Therapy Modalities, Postoperative Complications, Prognosis, Quality of Life, Single-Blind Method.
- MESH :
- prevention & control : Lymphedema.
- rehabilitation : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Adult, Aged, Aged, 80 and over, Cohort Studies, Exercise, Female, Follow-Up Studies, Humans, Mastectomy, Middle Aged, Neoplasm Staging, Patient Compliance, Patient Education as Topic, Physical Therapy Modalities, Postoperative Complications, Prognosis, Quality of Life, Single-Blind Method.
Abstract
This study aimed to determine the effect of a moderate, tailored exercise program on health-related quality of life, physical function, and arm volume in women receiving treatment for nonmetastatic breast cancer.
Women who were within 4–12 weeks of surgery for stage I–III breast cancer were randomized to center-based exercise and lymphedema education intervention or patient education. Functional Assessment of Cancer Therapy–Breast Cancer (FACT-B), 6-min walk, and arm volume were performed at 3-month intervals through 18 months. Repeated measures analysis of covariance was used to model the total meters walked over time, FACT-B scores, and arm volume. Models were adjusted for baseline measurement, baseline affected arm volume, number of nodes removed, age, self-reported symptoms, baseline SF-12 mental and physical component scores, visit, and treatment group.
Of the recruited 104 women, 82 completed all 18 months. Mean age (range) was 53.6 (32–82) years; 88% were Caucasian; 45% were employed full time; 44% were overweight; and 28% obese. Approximately, 46% had breast-conserving surgery; 79% had axillary node dissection; 59% received chemotherapy; and 64% received radiation. The intervention resulted in an average increase of 34.3 ml (SD=12.8) versus patient education (
With this early exercise intervention after breast cancer diagnosis, a significant improvement was achieved in physical function, with no decline in health-related quality of life or detrimental effect on arm volume.
Starting a supervised exercise regimen that is tailored to an individual’s strength and stamina within 3 months following breast cancer surgery appears safe and may hasten improvements in physical functioning.
Url:
DOI: 10.1007/s11764-011-0208-4
PubMed: 22160629
PubMed Central: 3900279
Affiliations:
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Le document en format XML
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Mccoy</name></author><author><name sortKey="Hopkins, Judith" sort="Hopkins, Judith" uniqKey="Hopkins J" first="Judith" last="Hopkins">Judith Hopkins</name></author><author><name sortKey="Levine, Edward" sort="Levine, Edward" uniqKey="Levine E" first="Edward" last="Levine">Edward Levine</name></author><author><name sortKey="Miller, Gary" sort="Miller, Gary" uniqKey="Miller G" first="Gary" last="Miller">Gary Miller</name></author><author><name sortKey="Ribisl, Paul" sort="Ribisl, Paul" uniqKey="Ribisl P" first="Paul" last="Ribisl">Paul Ribisl</name></author><author><name sortKey="Mihalko, Shannon L" sort="Mihalko, Shannon L" uniqKey="Mihalko S" first="Shannon L." last="Mihalko">Shannon L. 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Anderson</name></author><author><name sortKey="Kimmick, Gretchen G" sort="Kimmick, Gretchen G" uniqKey="Kimmick G" first="Gretchen G." last="Kimmick">Gretchen G. Kimmick</name></author><author><name sortKey="Mccoy, Thomas P" sort="Mccoy, Thomas P" uniqKey="Mccoy T" first="Thomas P." last="Mccoy">Thomas P. Mccoy</name></author><author><name sortKey="Hopkins, Judith" sort="Hopkins, Judith" uniqKey="Hopkins J" first="Judith" last="Hopkins">Judith Hopkins</name></author><author><name sortKey="Levine, Edward" sort="Levine, Edward" uniqKey="Levine E" first="Edward" last="Levine">Edward Levine</name></author><author><name sortKey="Miller, Gary" sort="Miller, Gary" uniqKey="Miller G" first="Gary" last="Miller">Gary Miller</name></author><author><name sortKey="Ribisl, Paul" sort="Ribisl, Paul" uniqKey="Ribisl P" first="Paul" last="Ribisl">Paul Ribisl</name></author><author><name sortKey="Mihalko, Shannon L" sort="Mihalko, Shannon L" uniqKey="Mihalko S" first="Shannon L." last="Mihalko">Shannon L. Mihalko</name></author></analytic><series><title level="j">Journal of cancer survivorship : research and practice</title><idno type="ISSN">1932-2259</idno><idno type="eISSN">1932-2267</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Breast Neoplasms (rehabilitation)</term><term>Breast Neoplasms (surgery)</term><term>Cohort Studies</term><term>Exercise</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Lymphedema (prevention & control)</term><term>Mastectomy</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Patient Compliance</term><term>Patient Education as Topic</term><term>Physical Therapy Modalities</term><term>Postoperative Complications</term><term>Prognosis</term><term>Quality of Life</term><term>Single-Blind Method</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Complications postopératoires</term><term>Exercice physique</term><term>Femelle</term><term>Humains</term><term>Lymphoedème ()</term><term>Mastectomie</term><term>Méthode en simple aveugle</term><term>Observance thérapeutique</term><term>Pronostic</term><term>Qualité de vie</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Techniques de physiothérapie</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (rééducation et réadaptation)</term><term>Éducation du patient comme sujet</term><term>Études de cohortes</term><term>Études de suivi</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="rééducation et réadaptation" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Exercise</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Mastectomy</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Patient Compliance</term><term>Patient Education as Topic</term><term>Physical Therapy Modalities</term><term>Postoperative Complications</term><term>Prognosis</term><term>Quality of Life</term><term>Single-Blind Method</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Complications postopératoires</term><term>Exercice physique</term><term>Femelle</term><term>Humains</term><term>Lymphoedème</term><term>Mastectomie</term><term>Méthode en simple aveugle</term><term>Observance thérapeutique</term><term>Pronostic</term><term>Qualité de vie</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Techniques de physiothérapie</term><term>Tumeurs du sein</term><term>Éducation du patient comme sujet</term><term>Études de cohortes</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P1">This study aimed to determine the effect of a moderate, tailored exercise program on health-related quality of life, physical function, and arm volume in women receiving treatment for nonmetastatic breast cancer.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Women who were within 4–12 weeks of surgery for stage I–III breast cancer were randomized to center-based exercise and lymphedema education intervention or patient education. Functional Assessment of Cancer Therapy–Breast Cancer (FACT-B), 6-min walk, and arm volume were performed at 3-month intervals through 18 months. Repeated measures analysis of covariance was used to model the total meters walked over time, FACT-B scores, and arm volume. Models were adjusted for baseline measurement, baseline affected arm volume, number of nodes removed, age, self-reported symptoms, baseline SF-12 mental and physical component scores, visit, and treatment group.</p></sec><sec id="S3"><title>Results</title><p id="P3">Of the recruited 104 women, 82 completed all 18 months. Mean age (range) was 53.6 (32–82) years; 88% were Caucasian; 45% were employed full time; 44% were overweight; and 28% obese. Approximately, 46% had breast-conserving surgery; 79% had axillary node dissection; 59% received chemotherapy; and 64% received radiation. The intervention resulted in an average increase of 34.3 ml (SD=12.8) versus patient education (<italic>p</italic>=0.01). Changes in FACT-B scores and arm volumes were not significantly different.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">With this early exercise intervention after breast cancer diagnosis, a significant improvement was achieved in physical function, with no decline in health-related quality of life or detrimental effect on arm volume.</p></sec><sec id="S5"><title>Implications for cancer survivors</title><p id="P5">Starting a supervised exercise regimen that is tailored to an individual’s strength and stamina within 3 months following breast cancer surgery appears safe and may hasten improvements in physical functioning.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Anderson, Roger T" sort="Anderson, Roger T" uniqKey="Anderson R" first="Roger T." last="Anderson">Roger T. Anderson</name><name sortKey="Hopkins, Judith" sort="Hopkins, Judith" uniqKey="Hopkins J" first="Judith" last="Hopkins">Judith Hopkins</name><name sortKey="Kimmick, Gretchen G" sort="Kimmick, Gretchen G" uniqKey="Kimmick G" first="Gretchen G." last="Kimmick">Gretchen G. Kimmick</name><name sortKey="Levine, Edward" sort="Levine, Edward" uniqKey="Levine E" first="Edward" last="Levine">Edward Levine</name><name sortKey="Mccoy, Thomas P" sort="Mccoy, Thomas P" uniqKey="Mccoy T" first="Thomas P." last="Mccoy">Thomas P. Mccoy</name><name sortKey="Mihalko, Shannon L" sort="Mihalko, Shannon L" uniqKey="Mihalko S" first="Shannon L." last="Mihalko">Shannon L. Mihalko</name><name sortKey="Miller, Gary" sort="Miller, Gary" uniqKey="Miller G" first="Gary" last="Miller">Gary Miller</name><name sortKey="Ribisl, Paul" sort="Ribisl, Paul" uniqKey="Ribisl P" first="Paul" last="Ribisl">Paul Ribisl</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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