LymphedemaV1, Pmc, Checkpoint, bibRecord, 003130

A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial

Identifieur interne : 003130 ( Pmc/Checkpoint ); précédent : 003129; suivant : 003131

A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial

Auteurs : Roger T. Anderson ; Gretchen G. Kimmick ; Thomas P. Mccoy ; Judith Hopkins ; Edward Levine ; Gary Miller ; Paul Ribisl ; Shannon L. Mihalko

Source :

Journal of cancer survivorship : research and practice [ 1932-2259 ] ; 2011.

RBID : PMC:3900279

Abstract

Objectives

This study aimed to determine the effect of a moderate, tailored exercise program on health-related quality of life, physical function, and arm volume in women receiving treatment for nonmetastatic breast cancer.

Methods

Women who were within 4–12 weeks of surgery for stage I–III breast cancer were randomized to center-based exercise and lymphedema education intervention or patient education. Functional Assessment of Cancer Therapy–Breast Cancer (FACT-B), 6-min walk, and arm volume were performed at 3-month intervals through 18 months. Repeated measures analysis of covariance was used to model the total meters walked over time, FACT-B scores, and arm volume. Models were adjusted for baseline measurement, baseline affected arm volume, number of nodes removed, age, self-reported symptoms, baseline SF-12 mental and physical component scores, visit, and treatment group.

Results

Of the recruited 104 women, 82 completed all 18 months. Mean age (range) was 53.6 (32–82) years; 88% were Caucasian; 45% were employed full time; 44% were overweight; and 28% obese. Approximately, 46% had breast-conserving surgery; 79% had axillary node dissection; 59% received chemotherapy; and 64% received radiation. The intervention resulted in an average increase of 34.3 ml (SD=12.8) versus patient education (p=0.01). Changes in FACT-B scores and arm volumes were not significantly different.

Conclusions

With this early exercise intervention after breast cancer diagnosis, a significant improvement was achieved in physical function, with no decline in health-related quality of life or detrimental effect on arm volume.

Implications for cancer survivors

Starting a supervised exercise regimen that is tailored to an individual’s strength and stamina within 3 months following breast cancer surgery appears safe and may hasten improvements in physical functioning.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900279

DOI: 10.1007/s11764-011-0208-4
PubMed: 22160629
PubMed Central: 3900279

Affiliations:

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PMC:3900279

Le document en format XML

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<author><name sortKey="Anderson, Roger T" sort="Anderson, Roger T" uniqKey="Anderson R" first="Roger T." last="Anderson">Roger T. Anderson</name>
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<author><name sortKey="Kimmick, Gretchen G" sort="Kimmick, Gretchen G" uniqKey="Kimmick G" first="Gretchen G." last="Kimmick">Gretchen G. Kimmick</name>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">This study aimed to determine the effect of a moderate, tailored exercise program on health-related quality of life, physical function, and arm volume in women receiving treatment for nonmetastatic breast cancer.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Women who were within 4–12 weeks of surgery for stage I–III breast cancer were randomized to center-based exercise and lymphedema education intervention or patient education. Functional Assessment of Cancer Therapy–Breast Cancer (FACT-B), 6-min walk, and arm volume were performed at 3-month intervals through 18 months. Repeated measures analysis of covariance was used to model the total meters walked over time, FACT-B scores, and arm volume. Models were adjusted for baseline measurement, baseline affected arm volume, number of nodes removed, age, self-reported symptoms, baseline SF-12 mental and physical component scores, visit, and treatment group.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Of the recruited 104 women, 82 completed all 18 months. Mean age (range) was 53.6 (32–82) years; 88% were Caucasian; 45% were employed full time; 44% were overweight; and 28% obese. Approximately, 46% had breast-conserving surgery; 79% had axillary node dissection; 59% received chemotherapy; and 64% received radiation. The intervention resulted in an average increase of 34.3 ml (SD=12.8) versus patient education (<italic>p</italic>
=0.01). Changes in FACT-B scores and arm volumes were not significantly different.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">With this early exercise intervention after breast cancer diagnosis, a significant improvement was achieved in physical function, with no decline in health-related quality of life or detrimental effect on arm volume.</p>
</sec>
<sec id="S5"><title>Implications for cancer survivors</title>
<p id="P5">Starting a supervised exercise regimen that is tailored to an individual’s strength and stamina within 3 months following breast cancer surgery appears safe and may hasten improvements in physical functioning.</p>
</sec>
</div>
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  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101307557</journal-id>
<journal-id journal-id-type="pubmed-jr-id">34604</journal-id>
<journal-id journal-id-type="nlm-ta">J Cancer Surviv</journal-id>
<journal-id journal-id-type="iso-abbrev">J Cancer Surviv</journal-id>
<journal-title-group><journal-title>Journal of cancer survivorship : research and practice</journal-title>
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<issn pub-type="epub">1932-2267</issn>
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<article-id pub-id-type="doi">10.1007/s11764-011-0208-4</article-id>
<article-id pub-id-type="manuscript">NIHMS520342</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Anderson</surname>
<given-names>Roger T.</given-names>
</name>
<aff id="A1">Department of Public Health Sciences, College of Medicine, Penn State Milton S. Hershey Medical Center, 600 Centerview Drive, Suite 2200, P.O. Box 855, Hershey, PA 17033-0855, USA</aff>
<email>rtanders@psu.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Kimmick</surname>
<given-names>Gretchen G.</given-names>
</name>
<aff id="A2">Department of Medicine, Duke University, Durham, NC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>McCoy</surname>
<given-names>Thomas P.</given-names>
</name>
<aff id="A3">Department of Biostatistical Sciences, WFUSOM, Winston-Salem, NC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Hopkins</surname>
<given-names>Judith</given-names>
</name>
<aff id="A4">Forsyth Regional Cancer Center, Winston-Salem, NC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Levine</surname>
<given-names>Edward</given-names>
</name>
<aff id="A5">Department of Surgery, WFUSOM, Winston-Salem, NC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Miller</surname>
<given-names>Gary</given-names>
</name>
<aff id="A6">Department of Health & Exercise Science, Wake Forest University (WFU), Winston-Salem, NC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Ribisl</surname>
<given-names>Paul</given-names>
</name>
<aff id="A7">Department of Health & Exercise Science, Wake Forest University (WFU), Winston-Salem, NC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Mihalko</surname>
<given-names>Shannon L.</given-names>
</name>
<aff id="A8">Department of Health & Exercise Science, Wake Forest University (WFU), Winston-Salem, NC, USA</aff>
</contrib>
</contrib-group>
<pub-date pub-type="nihms-submitted"><day>2</day>
<month>1</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>12</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>6</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>23</day>
<month>1</month>
<year>2014</year>
</pub-date>
<volume>6</volume>
<issue>2</issue>
<fpage>172</fpage>
<lpage>181</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/s11764-011-0208-4</pmc-comment>
      <permissions><copyright-statement>© Springer Science+Business Media, LLC 2011</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Objectives</title>
<p id="P1">This study aimed to determine the effect of a moderate, tailored exercise program on health-related quality of life, physical function, and arm volume in women receiving treatment for nonmetastatic breast cancer.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Women who were within 4–12 weeks of surgery for stage I–III breast cancer were randomized to center-based exercise and lymphedema education intervention or patient education. Functional Assessment of Cancer Therapy–Breast Cancer (FACT-B), 6-min walk, and arm volume were performed at 3-month intervals through 18 months. Repeated measures analysis of covariance was used to model the total meters walked over time, FACT-B scores, and arm volume. Models were adjusted for baseline measurement, baseline affected arm volume, number of nodes removed, age, self-reported symptoms, baseline SF-12 mental and physical component scores, visit, and treatment group.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Of the recruited 104 women, 82 completed all 18 months. Mean age (range) was 53.6 (32–82) years; 88% were Caucasian; 45% were employed full time; 44% were overweight; and 28% obese. Approximately, 46% had breast-conserving surgery; 79% had axillary node dissection; 59% received chemotherapy; and 64% received radiation. The intervention resulted in an average increase of 34.3 ml (SD=12.8) versus patient education (<italic>p</italic>
=0.01). Changes in FACT-B scores and arm volumes were not significantly different.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">With this early exercise intervention after breast cancer diagnosis, a significant improvement was achieved in physical function, with no decline in health-related quality of life or detrimental effect on arm volume.</p>
</sec>
<sec id="S5"><title>Implications for cancer survivors</title>
<p id="P5">Starting a supervised exercise regimen that is tailored to an individual’s strength and stamina within 3 months following breast cancer surgery appears safe and may hasten improvements in physical functioning.</p>
</sec>
</abstract>
<kwd-group><kwd>Breast cancer</kwd>
<kwd>Survivorship</kwd>
<kwd>Exercise</kwd>
<kwd>Physical activity</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>P30 CA012197 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Anderson, Roger T" sort="Anderson, Roger T" uniqKey="Anderson R" first="Roger T." last="Anderson">Roger T. Anderson</name>
<name sortKey="Hopkins, Judith" sort="Hopkins, Judith" uniqKey="Hopkins J" first="Judith" last="Hopkins">Judith Hopkins</name>
<name sortKey="Kimmick, Gretchen G" sort="Kimmick, Gretchen G" uniqKey="Kimmick G" first="Gretchen G." last="Kimmick">Gretchen G. Kimmick</name>
<name sortKey="Levine, Edward" sort="Levine, Edward" uniqKey="Levine E" first="Edward" last="Levine">Edward Levine</name>
<name sortKey="Mccoy, Thomas P" sort="Mccoy, Thomas P" uniqKey="Mccoy T" first="Thomas P." last="Mccoy">Thomas P. Mccoy</name>
<name sortKey="Mihalko, Shannon L" sort="Mihalko, Shannon L" uniqKey="Mihalko S" first="Shannon L." last="Mihalko">Shannon L. Mihalko</name>
<name sortKey="Miller, Gary" sort="Miller, Gary" uniqKey="Miller G" first="Gary" last="Miller">Gary Miller</name>
<name sortKey="Ribisl, Paul" sort="Ribisl, Paul" uniqKey="Ribisl P" first="Paul" last="Ribisl">Paul Ribisl</name>
</noCountry>
</tree>
</affiliations>
</record>

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A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial

A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial

Source :

Abstract

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