Tissue-engineered lymphatic graft for the treatment of lymphedema
Identifieur interne : 002391 ( Main/Exploration ); précédent : 002390; suivant : 002392Tissue-engineered lymphatic graft for the treatment of lymphedema
Auteurs : Muholan Kanapathy [Royaume-Uni] ; Nikhil M. Patel [Royaume-Uni] ; Deepak M. Kalaskar [Royaume-Uni] ; Afshin Mosahebi [Royaume-Uni] ; Babak J. Mehrara [États-Unis] ; Alexander M. Seifalian [Royaume-Uni]Source :
- The Journal of surgical research [ 0022-4804 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- methods : Nanotechnology, Tissue Engineering.
- physiology : Lymphatic Vessels.
- surgery : Lymphedema.
- therapy : Lymphedema.
- transplantation : Lymphatic Vessels.
- Humans, Regeneration.
Abstract
Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.
Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.
The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.
With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.
Url:
DOI: 10.1016/j.jss.2014.07.059
PubMed: 25248852
PubMed Central: 4394124
Affiliations:
- Royaume-Uni, États-Unis
- Angleterre, Grand Londres, État de New York
- Londres
- University College de Londres
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Le document en format XML
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<term>Lymphedema (surgery)</term>
<term>Lymphedema (therapy)</term>
<term>Nanotechnology (methods)</term>
<term>Regeneration</term>
<term>Tissue Engineering (methods)</term>
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<term>Régénération</term>
<term>Vaisseaux lymphatiques (physiologie)</term>
<term>Vaisseaux lymphatiques (transplantation)</term>
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<term>Tissue Engineering</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphatic Vessels</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.</p>
</sec>
</div>
</front>
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