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Tissue-engineered lymphatic graft for the treatment of lymphedema

Identifieur interne : 003385 ( Pmc/Corpus ); précédent : 003384; suivant : 003386

Tissue-engineered lymphatic graft for the treatment of lymphedema

Auteurs : Muholan Kanapathy ; Nikhil M. Patel ; Deepak M. Kalaskar ; Afshin Mosahebi ; Babak J. Mehrara ; Alexander M. Seifalian

Source :

RBID : PMC:4394124

Abstract

Background

Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.

Methods

Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.

Results

The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.

Conclusions

With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.


Url:
DOI: 10.1016/j.jss.2014.07.059
PubMed: 25248852
PubMed Central: 4394124

Links to Exploration step

PMC:4394124

Le document en format XML

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<title>Background</title>
<p id="P1">Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.</p>
</sec>
<sec id="S2">
<title>Methods</title>
<p id="P2">Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.</p>
</sec>
<sec id="S3">
<title>Results</title>
<p id="P3">The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.</p>
</sec>
<sec id="S4">
<title>Conclusions</title>
<p id="P4">With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.</p>
</sec>
</div>
</front>
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Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</aff>
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Department of Plastic and Reconstructive Surgery, Royal Free London NHS Foundation Trust Hospital, London, United Kingdom</aff>
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Department of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Centre, New York</aff>
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<italic>Corresponding author</italic>
. Division of Surgery and Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom. Tel.: 0020 7830 2901.
<email>a.seifalian@ucl.ac.uk</email>
(A.M. Seifalian)</corresp>
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<pub-date pub-type="nihms-submitted">
<day>8</day>
<month>4</month>
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<copyright-statement>© 2014 Elsevier Inc. All rights reserved.</copyright-statement>
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<abstract>
<sec id="S1">
<title>Background</title>
<p id="P1">Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.</p>
</sec>
<sec id="S2">
<title>Methods</title>
<p id="P2">Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.</p>
</sec>
<sec id="S3">
<title>Results</title>
<p id="P3">The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.</p>
</sec>
<sec id="S4">
<title>Conclusions</title>
<p id="P4">With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.</p>
</sec>
</abstract>
<kwd-group>
<kwd>Lymphedema</kwd>
<kwd>Tissue engineering</kwd>
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<kwd>Nanotechnology</kwd>
<kwd>Lymphatic regeneration</kwd>
</kwd-group>
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</front>
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