Tissue-engineered lymphatic graft for the treatment of lymphedema
Identifieur interne : 003385 ( Pmc/Corpus ); précédent : 003384; suivant : 003386Tissue-engineered lymphatic graft for the treatment of lymphedema
Auteurs : Muholan Kanapathy ; Nikhil M. Patel ; Deepak M. Kalaskar ; Afshin Mosahebi ; Babak J. Mehrara ; Alexander M. SeifalianSource :
- The Journal of surgical research [ 0022-4804 ] ; 2014.
Abstract
Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.
Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.
The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.
With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.
Url:
DOI: 10.1016/j.jss.2014.07.059
PubMed: 25248852
PubMed Central: 4394124
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PMC:4394124Le document en format XML
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<author><name sortKey="Kanapathy, Muholan" sort="Kanapathy, Muholan" uniqKey="Kanapathy M" first="Muholan" last="Kanapathy">Muholan Kanapathy</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
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<author><name sortKey="Patel, Nikhil M" sort="Patel, Nikhil M" uniqKey="Patel N" first="Nikhil M." last="Patel">Nikhil M. Patel</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kalaskar, Deepak M" sort="Kalaskar, Deepak M" uniqKey="Kalaskar D" first="Deepak M." last="Kalaskar">Deepak M. Kalaskar</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
</affiliation>
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<author><name sortKey="Mosahebi, Afshin" sort="Mosahebi, Afshin" uniqKey="Mosahebi A" first="Afshin" last="Mosahebi">Afshin Mosahebi</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
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<affiliation><nlm:aff id="A2">Department of Plastic and Reconstructive Surgery, Royal Free London NHS Foundation Trust Hospital, London, United Kingdom</nlm:aff>
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<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name>
<affiliation><nlm:aff id="A3">Department of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Centre, New York</nlm:aff>
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<author><name sortKey="Seifalian, Alexander M" sort="Seifalian, Alexander M" uniqKey="Seifalian A" first="Alexander M." last="Seifalian">Alexander M. Seifalian</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tissue-engineered lymphatic graft for the treatment of lymphedema</title>
<author><name sortKey="Kanapathy, Muholan" sort="Kanapathy, Muholan" uniqKey="Kanapathy M" first="Muholan" last="Kanapathy">Muholan Kanapathy</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
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<author><name sortKey="Patel, Nikhil M" sort="Patel, Nikhil M" uniqKey="Patel N" first="Nikhil M." last="Patel">Nikhil M. Patel</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
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<author><name sortKey="Kalaskar, Deepak M" sort="Kalaskar, Deepak M" uniqKey="Kalaskar D" first="Deepak M." last="Kalaskar">Deepak M. Kalaskar</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
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<author><name sortKey="Mosahebi, Afshin" sort="Mosahebi, Afshin" uniqKey="Mosahebi A" first="Afshin" last="Mosahebi">Afshin Mosahebi</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Plastic and Reconstructive Surgery, Royal Free London NHS Foundation Trust Hospital, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name>
<affiliation><nlm:aff id="A3">Department of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Centre, New York</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Seifalian, Alexander M" sort="Seifalian, Alexander M" uniqKey="Seifalian A" first="Alexander M." last="Seifalian">Alexander M. Seifalian</name>
<affiliation><nlm:aff id="A1">Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</nlm:aff>
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<series><title level="j">The Journal of surgical research</title>
<idno type="ISSN">0022-4804</idno>
<idno type="eISSN">1095-8673</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0376340</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5287</journal-id>
<journal-id journal-id-type="nlm-ta">J Surg Res</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Surg. Res.</journal-id>
<journal-title-group><journal-title>The Journal of surgical research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-4804</issn>
<issn pub-type="epub">1095-8673</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25248852</article-id>
<article-id pub-id-type="pmc">4394124</article-id>
<article-id pub-id-type="doi">10.1016/j.jss.2014.07.059</article-id>
<article-id pub-id-type="manuscript">NIHMS678316</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Tissue-engineered lymphatic graft for the treatment of lymphedema</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kanapathy</surname>
<given-names>Muholan</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Patel</surname>
<given-names>Nikhil M.</given-names>
</name>
<degrees>MRCS, MSc</degrees>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kalaskar</surname>
<given-names>Deepak M.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mosahebi</surname>
<given-names>Afshin</given-names>
</name>
<degrees>FRCS (Plast), PhD, MBA</degrees>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mehrara</surname>
<given-names>Babak J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seifalian</surname>
<given-names>Alexander M.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom</aff>
<aff id="A2"><label>b</label>
Department of Plastic and Reconstructive Surgery, Royal Free London NHS Foundation Trust Hospital, London, United Kingdom</aff>
<aff id="A3"><label>c</label>
Department of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Centre, New York</aff>
<author-notes><corresp id="cor1"><label>*</label>
<italic>Corresponding author</italic>
. Division of Surgery and Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom. Tel.: 0020 7830 2901. <email>a.seifalian@ucl.ac.uk</email>
(A.M. Seifalian)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>8</day>
<month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>30</day>
<month>7</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>4</month>
<year>2015</year>
</pub-date>
<volume>192</volume>
<issue>2</issue>
<fpage>544</fpage>
<lpage>554</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.jss.2014.07.059</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.</p>
</sec>
</abstract>
<kwd-group><kwd>Lymphedema</kwd>
<kwd>Tissue engineering</kwd>
<kwd>Lymphatic graft</kwd>
<kwd>Nanotechnology</kwd>
<kwd>Lymphatic regeneration</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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